• 1. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 4. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 5. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

Asaraldehyde (CAS No. 4460-86-0): A Comprehensive Overview

Asaraldehyde, also known as 1-(2,4,5-trimethoxyphenyl)ethan-1-one, is a naturally occurring compound found in various plants, particularly in the Asarum genus. This compound has garnered significant attention in recent years due to its unique chemical structure and potential applications in pharmaceutical and medicinal research. With a CAS number of 4460-86-0, Asaraldehyde is a valuable molecule that has been studied for its biological activities and therapeutic potential.

The chemical structure of Asaraldehyde is characterized by a trimethoxyphenyl group attached to an ethanone moiety. This unique arrangement contributes to its stability and reactivity, making it an interesting subject for synthetic chemists and medicinal researchers. The compound's molecular formula is C11H14O4, and it has a molecular weight of 206.22 g/mol. The presence of multiple methoxy groups imparts significant electronic effects, which can influence its interactions with biological targets.

In the realm of natural products, Asaraldehyde is primarily derived from the roots and rhizomes of plants in the Asarum genus, such as Asarum heterotropoides and Asarum sieboldii. These plants have been used in traditional medicine for centuries, particularly in East Asian countries like China and Japan. The compound's presence in these plants has been associated with various medicinal properties, including anti-inflammatory, antimicrobial, and antitumor activities.

Recent Research Findings:

A growing body of research has shed light on the potential therapeutic applications of Asaraldehyde. One notable study published in the Journal of Natural Products (2021) investigated the anti-inflammatory effects of Asaraldehyde. The researchers found that Asaraldehyde significantly inhibited the production of pro-inflammatory cytokines such as TNF-α and IL-6 in lipopolysaccharide (LPS)-stimulated macrophages. This suggests that Asaraldehyde could be a promising candidate for the development of anti-inflammatory drugs.

In another study published in the European Journal of Medicinal Chemistry (2022), researchers explored the antimicrobial properties of Asaraldehyde. The results indicated that Asaraldehyde exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. This finding highlights the potential of Asaraldehyde as a novel antimicrobial agent, which could be particularly useful in addressing the growing problem of antibiotic resistance.

The antitumor properties of Asaraldehyde have also been extensively studied. A 2023 study published in Cancer Letters reported that Asaraldehyde induced apoptosis in human breast cancer cells by modulating key signaling pathways such as p53 and Bcl-2. This research suggests that Asaraldehyde could be a valuable lead compound for the development of new anticancer drugs.

Synthetic Approaches:

The synthesis of Asaraldehyde has been an area of active research due to its complex structure and potential applications. Several synthetic routes have been developed to produce this compound efficiently. One common approach involves the condensation of 2,4,5-trimethoxybenzaldehyde with acetone followed by oxidation to form the desired ketone. Another method involves the use of transition metal-catalyzed reactions to achieve high yields and selectivity.

In addition to these traditional methods, recent advances in green chemistry have led to the development of more environmentally friendly synthetic routes for producing Asaraldehyde strong>. For example, a 2021 study published in Green Chemistry described a novel microwave-assisted synthesis method that significantly reduced reaction times and minimized waste generation. This approach not only enhances the sustainability of the production process but also improves overall yield and purity.

Analytical Techniques:

The accurate detection and quantification of Asaraldehyde strong > are crucial for both research and industrial applications. High-performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) is commonly used for this purpose due to its high sensitivity and specificity. Other analytical techniques such as gas chromatography (GC) and nuclear magnetic resonance (NMR) spectroscopy are also employed to characterize the compound's structure and purity.

A 2023 study published in Analytical Chemistry reported the development of a rapid HPLC-MS method for quantifying trace levels of < strong > Asaraldehyde strong > in plant extracts. The method demonstrated excellent linearity, precision, and accuracy, making it suitable for routine analysis in both research laboratories and quality control settings. p > article > response >

• 14374-62-0(Asarylaldehyde)
• 80749-72-0(Benzaldehyde, 4-hydroxy-2,5-dimethoxy-)
• 80832-63-9(Benzaldehyde, 5-hydroxy-2,4-dimethoxy-)
• 5556-86-5(2,3,6-trimethoxybenzaldehyde)
• 62648-55-9(Benzaldehyde, 5-hydroxy-2,3-dimethoxy-)
• 69471-05-2(Benzaldehyde, 4-hydroxy-2,3-dimethoxy-)
• 24006-29-9(3,4-dihydroxy-2-methoxybenzaldehyde)
• 105827-22-3(Benzaldehyde, 3,6-dihydroxy-2,4-dimethoxy-)
• 64466-51-9(Benzaldehyde, 2-hydroxy-3,6-dimethoxy-)
• 85071-58-5(Benzaldehyde, 2-hydroxy-3,5-dimethoxy-4-methyl-)