• 1. Flash vacuum pyrolysis over magnesium. Part 1. Pyrolysis of benzylic, other aryl/alkyl and aliphatic halides
  R. Alan Aitken,Philip K. G. Hodgson,John J. Morrison,Adebayo O. Oyewale J. Chem. Soc. Perkin Trans. 1 2002 402
• 2. Notes
  Roy J. Gritter,Royce S. Woosley,Peter Walker,A. J. Birch,J. Winter,Karl O. Christe,Attila E. Pavlath,W. Carruthers,G. Harris,I. C. MacWilliam,G. Valkanas,N. K. Roberts,Henri Ulrich,A. A. R. Sayigh,Alwyn G. Evans,B. J. Tabner,Joseph V. Urenovitch,Rade Pejic,Alan G. MacDiarmid,B. R. Brown,A. H. Todd,J. G. Pritchard,R. L. Vollmer,Paul J. Scheuer,Frank Werny,R. K. Smalley,H. Suschitzky,C. D. Foxall,J. W. W. Morgan,D. F. Evans,G. O. P. Doherty,N. B. Haynes,W. B. Whalley,H. J. Rylance J. Chem. Soc. 1963 5544
• 3. Towards solution processable air stable p-type organic semiconductors: synthesis and evaluation of mono and di-fluorinated pentacene derivatives
  Jaroslaw M. Wasikiewicz,Laila Abu-Sen,Andrew B. Horn,Jacobus M. Koelewijn,Adam V. S. Parry,John J. Morrison,Stephen G. Yeates J. Mater. Chem. C 2016 4 7309
• 4. Notes
  E. G. E. Hawkins,W. F. Maddams,A. C. Hazell,D. S. Urch,David A. Buckingham,J. L. E. Cheong,J. E. Fergusson,C. J. Wilkins,Ernst D. Bergmann,Arnon Shani,B. C. Saunders,P. Simpson,Edmond N. Gabali,Elhosseiny M. Abdallah,R. C. Cambie,E. R. H. Jones,G. Lowe,J. L. Boston,S. O. Grim,G. Wilkinson,Lindsay H. Briggs,P. W. Le Quesne,J. A. Silk,L. A. Summers,G. Valkanas,H. Hopff J. Chem. Soc. 1963 3456

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives o-Xylenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Xylenes o-Xylenes
• Solvents and Organic Chemicals Organic Compounds Organic Halides

Introduction to 3-Fluoro-O-xylene (CAS No. 443-82-3)

3-Fluoro-O-xylene, with the chemical formula C₈H₉F, is a versatile compound that has garnered significant attention in the fields of chemistry, biology, and pharmaceuticals. This compound, identified by its CAS number 443-82-3, is a fluorinated derivative of o-xylene, characterized by its unique chemical structure and properties. The presence of a fluorine atom in the ortho position imparts distinct characteristics to the molecule, making it a valuable intermediate in various synthetic processes.

The physical and chemical properties of 3-Fluoro-O-xylene are well-documented in the scientific literature. It is a colorless liquid with a characteristic aromatic odor. The compound has a molecular weight of 126.15 g/mol and a boiling point of approximately 156°C at standard atmospheric pressure. Its density is around 1.07 g/cm3 at room temperature. These properties make it suitable for use in a wide range of applications, from laboratory research to industrial processes.

In the realm of organic synthesis, 3-Fluoro-O-xylene serves as an important building block for the preparation of more complex molecules. The fluorine atom in its structure can participate in various chemical reactions, such as nucleophilic substitution, electrophilic aromatic substitution, and coupling reactions. These reactions are crucial for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Recent studies have highlighted the utility of fluorinated compounds in enhancing the biological activity and metabolic stability of drug candidates.

The biological significance of 3-Fluoro-O-xylene has also been explored in several research papers. Fluorinated aromatic compounds are known to exhibit unique interactions with biological targets, which can lead to improved pharmacological properties. For instance, the introduction of fluorine atoms into drug molecules can enhance their lipophilicity, which in turn can improve their absorption and distribution within the body. This property is particularly important for drugs that need to cross biological membranes to reach their target sites.

In the context of drug discovery and development, 3-Fluoro-O-xylene has been used as a starting material for the synthesis of potential therapeutic agents. One notable example is its application in the development of anti-cancer drugs. Fluorinated derivatives have shown promise in inhibiting specific enzymes involved in cancer cell proliferation and survival. Additionally, these compounds can be designed to have reduced toxicity compared to their non-fluorinated counterparts, making them safer for clinical use.

The environmental impact of 3-Fluoro-O-xylene is another area of interest for researchers and regulatory bodies. While it is not classified as a hazardous substance under current regulations, its potential effects on ecosystems must be carefully evaluated. Studies have shown that fluorinated compounds can persist in the environment for extended periods due to their chemical stability. Therefore, efforts are being made to develop more sustainable synthetic routes and disposal methods to minimize any adverse environmental impacts.

In conclusion, 3-Fluoro-O-xylene (CAS No. 443-82-3) is a multifaceted compound with significant applications in various scientific and industrial fields. Its unique chemical properties make it an invaluable intermediate in organic synthesis and a promising candidate for drug development. As research continues to advance, it is likely that new applications and insights into the behavior of this compound will emerge, further solidifying its importance in the scientific community.

• 452-67-5(2,5-Difluorotoluene)
• 615-60-1(4-Chloro-1,2-dimethylbenzene)
• 31599-60-7(1-Iodo-2,3-Dimethylbenzene)
• 461-97-2(5-Fluoro-m-xylene)
• 488-23-3(1,2,3,4-Tetramethylbenzene)
• 700-12-9(1,2,3,4,5-pentamethylbenzene)
• 452-64-2(4-Fluoro-o-xylene)
• 608-23-1(3-Chloro-o-xylene)
• 619-04-5(3,4-Dimethylbenzoic acid)
• 934-80-5(4-Ethyl-1,2-dimethylbenzene)