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• Solvents and Organic Chemicals Organic Compounds Benzenoids Naphthalenes Naphthalene sulfonic acids and derivatives 1-naphthalene sulfonic acids and derivatives

Comprehensive Overview of N-Dansyl-1-(2-methoxyphenyl)piperazine (CAS No. 439935-18-9)

N-Dansyl-1-(2-methoxyphenyl)piperazine (CAS No. 439935-18-9) is a fluorescently labeled derivative of piperazine, widely utilized in biochemical and pharmacological research. This compound combines the dansyl group, known for its strong fluorescence properties, with a methoxyphenyl-piperazine backbone, making it invaluable for studies involving receptor binding, enzyme interactions, and cellular imaging. Researchers frequently employ this compound due to its high sensitivity and specificity in fluorescence-based assays.

The CAS No. 439935-18-9 is often associated with advanced research in neuroscience and drug discovery. Its unique structure allows it to act as a probe for serotonin receptors, particularly the 5-HT_1A and 5-HT_2A subtypes, which are critical targets for treating anxiety, depression, and other neurological disorders. Given the rising global interest in mental health and neuropharmacology, N-Dansyl-1-(2-methoxyphenyl)piperazine has garnered significant attention in academic and pharmaceutical circles.

One of the key advantages of this compound is its compatibility with modern analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS). Its fluorescence properties enable real-time monitoring of molecular interactions, making it a preferred choice for live-cell imaging and high-throughput screening (HTS). These applications align with current trends in personalized medicine and precision drug development, where understanding molecular mechanisms at a granular level is paramount.

In addition to its research applications, N-Dansyl-1-(2-methoxyphenyl)piperazine is also explored for its potential in diagnostic tools. The dansyl moiety's stability and bright emission make it suitable for designing fluorescent sensors to detect biomarkers associated with neurodegenerative diseases like Alzheimer's and Parkinson's. This aligns with the growing demand for non-invasive diagnostic methods, a hot topic in medical research today.

From a synthetic chemistry perspective, the compound's structure offers versatility for further modifications. Researchers often derivatize the piperazine ring or the methoxyphenyl group to enhance its binding affinity or fluorescence yield. Such modifications are frequently discussed in forums and publications focusing on structure-activity relationships (SAR) and medicinal chemistry optimization.

Given its niche yet critical role, N-Dansyl-1-(2-methoxyphenyl)piperazine is often searched alongside terms like "fluorescent probes for serotonin receptors", "dansyl-labeled piperazine derivatives", and "HTS compatible fluorescent compounds". These long-tail keywords reflect the compound's specialized applications and the precision required in modern research workflows.

In summary, CAS No. 439935-18-9 represents a sophisticated tool for cutting-edge research, bridging gaps between fluorescence spectroscopy, neuropharmacology, and diagnostic innovation. Its relevance in contemporary science ensures continued interest and exploration, particularly in fields prioritizing molecular-level insights and therapeutic advancements.

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