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Comprehensive Overview of 1-Propanone, 1-(3-bromo-4-methoxyphenyl)- (CAS No. 4374-36-1)

1-Propanone, 1-(3-bromo-4-methoxyphenyl)- (CAS No. 4374-36-1) is an organic compound widely recognized for its unique chemical structure and versatile applications in research and industrial processes. This compound, also referred to as 3-bromo-4-methoxypropiophenone, belongs to the family of aromatic ketones, which are pivotal intermediates in synthetic chemistry. Its molecular formula, C₁₀H₁₁BrO₂, highlights the presence of a bromine atom and a methoxy group, contributing to its reactivity and functional utility.

In recent years, the demand for specialized organic intermediates like 1-Propanone, 1-(3-bromo-4-methoxyphenyl)- has surged, driven by advancements in pharmaceuticals, agrochemicals, and material science. Researchers and manufacturers frequently search for "CAS 4374-36-1 suppliers" or "3-bromo-4-methoxypropiophenone synthesis" to source high-purity batches or explore novel synthetic routes. The compound's brominated aromatic core makes it a valuable building block for constructing complex molecules, particularly in drug discovery and fine chemical production.

One of the key trends in organic chemistry is the shift toward sustainable and efficient synthesis methods. 1-Propanone, 1-(3-bromo-4-methoxyphenyl)- has garnered attention in green chemistry discussions, with queries like "eco-friendly bromination techniques" or "catalytic approaches for aromatic ketones" becoming increasingly common. Innovations in catalytic bromination and solvent-free reactions have improved the compound's accessibility while minimizing environmental impact.

The compound's structural features also make it relevant in the study of structure-activity relationships (SAR). For instance, the methoxy group's electron-donating properties and the bromine atom's steric effects influence its reactivity in cross-coupling reactions, such as Suzuki or Heck couplings. These reactions are critical for creating biaryl structures, a motif prevalent in many bioactive molecules. Searches for "CAS 4374-36-1 in cross-coupling reactions" reflect this academic and industrial interest.

From an analytical perspective, 1-Propanone, 1-(3-bromo-4-methoxyphenyl)- is characterized using techniques like NMR spectroscopy, HPLC, and mass spectrometry. Laboratories often seek "analytical methods for 3-bromo-4-methoxypropiophenone" to ensure purity and compliance with regulatory standards. The compound's stability under various conditions is another area of investigation, particularly for storage and transportation protocols.

In material science, derivatives of 1-Propanone, 1-(3-bromo-4-methoxyphenyl)- have been explored for their potential in polymer chemistry and optoelectronic materials. The bromine atom serves as a handle for further functionalization, enabling the design of advanced materials with tailored properties. Queries like "brominated aromatic ketones in OLEDs" underscore its relevance in cutting-edge applications.

Safety and handling guidelines for CAS 4374-36-1 emphasize standard laboratory practices, including the use of personal protective equipment (PPE) and proper ventilation. While the compound is not classified as hazardous under typical conditions, users often search for "safe handling of brominated ketones" to adhere to best practices. Regulatory compliance, such as REACH or TSCA, is also a frequent topic of inquiry.

In summary, 1-Propanone, 1-(3-bromo-4-methoxyphenyl)- (CAS No. 4374-36-1) is a multifaceted compound with significant applications across chemistry and materials science. Its role as a synthetic intermediate, combined with ongoing research into sustainable methodologies, ensures its continued relevance. Whether for academic research or industrial production, understanding its properties and applications is essential for leveraging its full potential.

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