• 1. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 2. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 3. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 4. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 5. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833

Comprehensive Overview of 3-Fluoro-4-(1H-pyrazol-1-yl)benzaldehyde (CAS No. 433920-88-8)

3-Fluoro-4-(1H-pyrazol-1-yl)benzaldehyde (CAS No. 433920-88-8) is a highly specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This fluorinated benzaldehyde derivative is characterized by its unique molecular structure, which combines a pyrazole ring with a benzaldehyde core. The presence of the fluoro substituent at the 3-position enhances its reactivity and potential applications in drug discovery and material science. Researchers are particularly interested in its role as a key intermediate in the synthesis of bioactive molecules, owing to its ability to participate in diverse chemical reactions such as condensation, nucleophilic substitution, and cross-coupling reactions.

In recent years, the demand for 3-Fluoro-4-(1H-pyrazol-1-yl)benzaldehyde has surged due to its relevance in the development of small-molecule inhibitors and heterocyclic compounds. Its structural features make it a valuable building block for designing kinase inhibitors, which are pivotal in targeting cancer and inflammatory diseases. The compound's pyrazole moiety is particularly noteworthy, as pyrazole derivatives are known for their pharmacological versatility and presence in FDA-approved drugs. Additionally, the aldehyde functional group offers a reactive handle for further derivatization, enabling the creation of libraries of compounds for high-throughput screening.

The synthesis of 3-Fluoro-4-(1H-pyrazol-1-yl)benzaldehyde typically involves multi-step organic reactions, including Pd-catalyzed cross-coupling and halogenation processes. Advanced techniques such as microwave-assisted synthesis have been explored to improve yield and efficiency. Analytical methods like HPLC, NMR, and mass spectrometry are employed to ensure purity and structural integrity. The compound's physicochemical properties, including solubility and stability, are critical for its application in formulation studies. Researchers are also investigating its potential in green chemistry initiatives, aiming to reduce environmental impact during production.

From a commercial perspective, 3-Fluoro-4-(1H-pyrazol-1-yl)benzaldehyde is supplied by leading chemical manufacturers and custom synthesis providers. Its market growth is driven by the expanding pharmaceutical industry and the increasing focus on precision medicine. The compound's CAS No. 433920-88-8 serves as a unique identifier in regulatory and safety documentation, ensuring compliance with global standards. As the scientific community continues to explore its applications, 3-Fluoro-4-(1H-pyrazol-1-yl)benzaldehyde remains a compound of significant interest for both academic and industrial research.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)