• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 3. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 4. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 5. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acids and conjugates Halogenated fatty acids

Comprehensive Guide to 2-Bromo-4-methylpentanoic acid (CAS No. 42990-24-9): Properties, Applications, and Industry Insights

2-Bromo-4-methylpentanoic acid (CAS No. 42990-24-9) is a versatile organic compound widely utilized in pharmaceutical synthesis, agrochemical production, and specialty chemical research. This brominated carboxylic acid derivative is characterized by its unique molecular structure, combining a bromo substituent with a branched alkyl chain, making it valuable for stereoselective reactions and intermediate synthesis. With increasing interest in chiral building blocks for drug development, this compound has gained attention in medicinal chemistry circles.

The growing demand for high-purity chemical intermediates in API manufacturing (Active Pharmaceutical Ingredients) has positioned 2-Bromo-4-methylpentanoic acid as a compound of significant industrial relevance. Researchers frequently search for "CAS 42990-24-9 solubility", "2-Bromo-4-methylpentanoic acid synthesis method", and "safety profile of brominated acids", reflecting key user concerns in the field. The compound's reactivity profile makes it particularly useful for nucleophilic substitution reactions, a property extensively documented in recent organic chemistry publications.

From an environmental chemistry perspective, 2-Bromo-4-methylpentanoic acid has been studied for its biodegradation pathways, addressing modern concerns about green chemistry and sustainable synthesis. Analytical techniques like HPLC purification and NMR characterization are commonly employed to ensure product quality, topics frequently queried in scientific databases. The compound's physical-chemical properties (including its melting point range of 45-50°C and molecular weight of 195.04 g/mol) make it suitable for various laboratory applications.

In peptide chemistry, 2-Bromo-4-methylpentanoic acid serves as a valuable side-chain modifier, with researchers often investigating its "coupling efficiency" and "protection group compatibility". The pharmaceutical industry particularly values its role in creating chiral auxiliaries, evidenced by numerous patent filings. Current market trends show increased interest in "cost-effective synthesis routes" and "scale-up production" methods for this compound.

The spectroscopic characterization of 2-Bromo-4-methylpentanoic acid reveals distinctive IR absorption bands at 1700-1720 cm^-1 (C=O stretch) and 600-800 cm^-1 (C-Br stretch), important for quality control purposes. Modern computational chemistry approaches have enabled better understanding of its conformational stability, addressing frequent queries about "molecular modeling of bromo acids". These computational studies complement traditional experimental data, providing comprehensive insights for industrial applications.

Storage and handling of 2-Bromo-4-methylpentanoic acid require attention to moisture sensitivity and thermal stability considerations, topics commonly searched by laboratory technicians. The compound's shelf life optimization under various conditions has been the subject of recent stability studies, particularly relevant for inventory management in chemical supply chains. Proper container selection (typically amber glass under inert atmosphere) significantly impacts long-term storage outcomes.

Emerging applications in material science have expanded the utility of 2-Bromo-4-methylpentanoic acid, particularly in the development of functionalized polymers. Researchers are investigating its potential as a monomer precursor for specialty coatings, responding to industry demands for high-performance materials. This interdisciplinary relevance has generated increased academic interest, with publication rates growing approximately 15% annually over the past five years according to scientific literature analyses.

Quality specifications for 2-Bromo-4-methylpentanoic acid typically require ≥98% chemical purity, with strict limits on heavy metal content and residual solvents for pharmaceutical-grade material. Analytical methods development for this compound frequently addresses "impurity profiling" challenges, particularly regarding isomeric byproducts. Advanced chromatographic techniques have significantly improved the detection sensitivity for trace contaminants in commercial samples.

The global market for 2-Bromo-4-methylpentanoic acid reflects broader trends in fine chemicals demand, with Asia-Pacific regions showing particularly strong growth in production capacity. Recent supply chain analyses indicate shifting patterns in raw material sourcing for its synthesis, influenced by regulatory changes in bromine chemistry. These market dynamics are increasingly important for procurement specialists and strategic planners in chemical manufacturing.

Future research directions for 2-Bromo-4-methylpentanoic acid are likely to focus on catalytic synthesis improvements and waste minimization strategies, aligning with circular economy principles in the chemical industry. The compound's role in asymmetric synthesis continues to attract attention from academic researchers and industrial chemists alike, ensuring its ongoing relevance in advanced organic synthesis applications.

• 89367-98-6(Nonadecanoic acid, 2-bromo-)
• 91423-84-6(Hexanoic acid, 2-bromo-, (2S)-)
• 28659-87-2((S)-2-Bromo-4-methylpentanoic acid)
• 42880-22-8(2-Bromo-3-methylpentanoic acid)
• 32835-74-8(Pentanoic acid,2-bromo-, (2S)-)
• 82144-78-3(Pentadecanoicacid, 2-bromo-)
• 5428-00-2(2-bromo-2-cyclohexylacetic acid)
• 49628-52-6(Pentanoic acid,2-bromo-4-methyl-)
• 70610-87-6(2-BROMOOCTANOIC ACID)
• 95658-34-7(Tridecanoic acid,2-bromo-)