Cas no 4218-81-9 (2,6-Di-O-palmitoyl-L-ascorbic Acid)

2,6-Di-O-palmitoyl-L-ascorbic Acid is a lipid-soluble derivative of ascorbic acid, where palmitoyl groups are esterified at the 2- and 6-positions of the L-ascorbic acid backbone. This modification enhances stability against oxidation and improves lipid compatibility, making it suitable for applications in lipid-based formulations. The compound retains the antioxidant properties of ascorbic acid while offering superior skin penetration in cosmetic and pharmaceutical applications. Its amphiphilic nature allows for integration into emulsified systems, broadening its utility in topical delivery. The esterification also prolongs activity, providing sustained release of ascorbic acid upon enzymatic hydrolysis. This derivative is particularly valued in skincare for its combined antioxidant and moisturizing effects.
2,6-Di-O-palmitoyl-L-ascorbic Acid structure
4218-81-9 structure
Product Name:2,6-Di-O-palmitoyl-L-ascorbic Acid
CAS No:4218-81-9
MF:C38H68O8
MW:652.9417
MDL:MFCD00059738
CID:927865
PubChem ID:87562297
Update Time:2025-05-22

2,6-Di-O-palmitoyl-L-ascorbic Acid Chemical and Physical Properties

Names and Identifiers

    • l-ascorbyl 2,6-dipalmitate
    • 2,6-Di-O-palmitoyl-L-ascorbic Acid
    • [(2S)-2-[(2S)-4-hexadecanoyloxy-3-hydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] hexadecanoate
    • ascorbic acid 2,6-dipalmitate
    • ascorbyl 2,6-dipalmitate
    • vitamin C 2,6-dipalmitate
    • TUYRNAGGIJZRNM-UHFFFAOYSA-N
    • [2-(4-hexadecanoyloxy-5-hydroxy-3-oxofuran-2-yl)-2-hydroxyethyl] hexadecanoate
    • [2-(4-Hexadecanoyloxy-3-hydroxy-5-oxo-2H-furan-2-yl)-2-hydroxyethyl] hexadecanoate
    • NIKKOL CP
    • (S)-2-Hydroxy-2-((R)-3-hydroxy-5-oxo-4-(palmitoyloxy)-2,5-dihydrofuran-2-yl)ethyl palmitate
    • DTXSID00724552
    • L-ASCORBIC ACID, DIPALMITATE
    • [(2S)-2-[(2R)-4-hexadecanoyloxy-3-hydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] hexadecanoate
    • l-(+)-Ascorbic acid 2,6-dihexadecanoate
    • AKOS028109783
    • (S)-2-Hydroxy-2-((R)-3-hydroxy-5-oxo-4-(palmitoyloxy)-2,5-dihydrofuran-2-yl)ethylpalmitate
    • (5S)-5-[2-(Hexadecanoyloxy)-1-hydroxyethyl]-4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl hexadecanoate
    • A0757
    • CS-0185930
    • VITAMIN C DIPALMITATE
    • SCHEMBL1974137
    • MFCD00059738
    • (2S)-2-[(2R)-4-(HEXADECANOYLOXY)-3-HYDROXY-5-OXO-2H-FURAN-2-YL]-2-HYDROXYETHYL HEXADECANOATE
    • 4218-81-9
    • D88316
    • ASCORBYL DIPALMITATE, L-
    • CHEMBL140097
    • HY-W127735
    • MDL： MFCD00059738
    • Inchi： 1S/C38H68O8/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(40)44-31-32(39)36-35(42)37(38(43)46-36)45-34(41)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32,36,39,42H,3-31H2,1-2H3
    • InChI Key： TUYRNAGGIJZRNM-UHFFFAOYSA-N
    • SMILES： O(C([H])([H])C([H])(C1([H])C(=C(C(=O)O1)OC(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O)O[H])O[H])C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O

Computed Properties

  • Exact Mass: 652.49100
  • Monoisotopic Mass: 652.49141912g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 8
  • Heavy Atom Count: 46
  • Rotatable Bond Count: 34
  • Complexity: 824
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 119
  • XLogP3: 14.1

Experimental Properties

  • Color/Form: Uncertain
  • Melting Point: 112.0 to 116.0 deg-C
  • Refractive Index: 21.5 ° (C=0.8, EtOH)
  • PSA: 119.36000
  • LogP: 10.09130
  • Solubility: Uncertain

2,6-Di-O-palmitoyl-L-ascorbic Acid Pricemore >>

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D525503-250mg
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