Cas no 41838-46-4 (1-methylpiperidin-4-amine)

1-Methylpiperidin-4-amine is a secondary amine derivative of piperidine, featuring a methyl group at the 1-position and an amine functional group at the 4-position. This compound serves as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. Its rigid piperidine scaffold and reactive amine group make it valuable for constructing biologically active molecules, including CNS-targeting drugs and catalysts. The methyl substitution enhances lipophilicity, potentially improving membrane permeability in drug design. It is typically handled under inert conditions due to its sensitivity to air and moisture. Available in high purity grades, it is suitable for research and industrial applications requiring precise structural control.
1-methylpiperidin-4-amine structure
1-methylpiperidin-4-amine structure
Product Name:1-methylpiperidin-4-amine
CAS No:41838-46-4
MF:C6H14N2
MW:114.188761234283
MDL:MFCD01570549
CID:55486
PubChem ID:2737531
Update Time:2025-11-02

1-methylpiperidin-4-amine Chemical and Physical Properties

Names and Identifiers

    • 4-Amino-1-methylpiperidine
    • 4-Amino-1-methylpiperdine
    • 1-(5-Bromopyrimidin-2-yl)-[1,4]-diazepane
    • 1-Methylpiperidin-4-amine
    • N-Methyl-4-amino piperidine
    • N-METHYLPIPERIDIN-4-AMINE
    • 1-methyl-4-amino-piperidine
    • 1-methyl-4-piperidinamine
    • 1-methyl-4-piperidylamine
    • 1-methylpiperidin-4-ylamine
    • 1-methyl-piperidin-4-ylamine
    • 4-amino-N-methylpiperidine
    • N-Methyl-4-aminopiperidine
    • 4-Amino-1-methyl-piperidine
    • 4-amino 1-N-methyl piperidine
    • SCHEMBL56445
    • CS-W016605
    • 41838-46-4
    • BP-10132
    • NS00120130
    • AC-7577
    • 4-amino-1-methyl piperidine
    • A6873
    • MFCD01570549
    • J-515773
    • 1-methyl-4-aminopiperidine
    • DTXSID80372116
    • 4-PIPERIDINAMINE, 1-METHYL-
    • methylpiperidin-4-amine
    • F0001-1170
    • N-methyl-4-amino-piperidine
    • Z89283296
    • PB32253
    • 4-amino 1-methylpiperidine
    • BCP05286
    • FT-0601092
    • 4-amino N-methylpiperidine
    • 1-methylpiperidine-4-amine
    • HMS1788L05
    • AKOS000122870
    • 1-Methyl-4-piperidinamine, AldrichCPR
    • ALOCUZOKRULSAA-UHFFFAOYSA-N
    • EN300-12909
    • 1-methyl 4-piperidylamine
    • BB 0237260
    • SCHEMBL7300513
    • 1-methyl-piperidin-4-yl amine
    • W-202719
    • LF-0517
    • AM20100109
    • 4-amino-N-methyl-piperidine
    • trans-4-amino-1-methylpiperidine
    • DTXCID40323149
    • ALBB-000072
    • DB-006616
    • STK349280
    • A2046
    • 1-methylpiperidin-4-amine
    • MDL： MFCD01570549
    • Inchi： 1S/C6H14N2/c1-8-4-2-6(7)3-5-8/h6H,2-5,7H2,1H3
    • InChI Key： ALOCUZOKRULSAA-UHFFFAOYSA-N
    • SMILES： N1(C)CCC(CC1)N

Computed Properties

  • Exact Mass: 114.11600
  • Monoisotopic Mass: 114.116
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 8
  • Rotatable Bond Count: 0
  • Complexity: 64.9
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: -0.1
  • Topological Polar Surface Area: 29.3A^2

Experimental Properties

  • Color/Form: Not determined
  • Density: 0.910(lit.)
  • Melting Point: 203-207
  • Boiling Point: 83°C/48mmHg(lit.)
  • Flash Point: 39.2℃
  • Refractive Index: 1.4700-1.4740
  • PSA: 29.26000
  • LogP: 0.67750
  • Solubility: Not determined
  • Vapor Pressure: No data available

1-methylpiperidin-4-amine Security Information

1-methylpiperidin-4-amine Customs Data

  • HS CODE：2933990090
  • Customs Data：

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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1-methylpiperidin-4-amine Production Method

1-methylpiperidin-4-amine Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:41838-46-4)1-methylpiperidin-4-amine
Order Number:A6873
Stock Status:in Stock
Quantity:100g/500g/1000g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 16:04
Price ($):175.0/789.0/1420.0

1-methylpiperidin-4-amine Related Literature

Related Categories

Additional information on 1-methylpiperidin-4-amine

Recent Advances in the Research of 1-Methylpiperidin-4-amine (CAS: 41838-46-4) and Its Applications in Chemical Biology and Medicine

1-Methylpiperidin-4-amine (CAS: 41838-46-4) is a key intermediate in the synthesis of various bioactive molecules and pharmaceuticals. Recent studies have highlighted its significance in drug discovery, particularly in the development of central nervous system (CNS) therapeutics and enzyme inhibitors. This research briefing consolidates the latest findings on its synthesis, biological activity, and potential applications in the chemical biology and pharmaceutical industries.

A study published in the Journal of Medicinal Chemistry (2023) explored the use of 1-methylpiperidin-4-amine as a building block for novel serotonin receptor modulators. The research demonstrated that derivatives of this compound exhibit high affinity for 5-HT1A and 5-HT7 receptors, suggesting potential applications in treating anxiety and depression. The study employed molecular docking and in vitro assays to validate the compound's interactions with target proteins.

Another significant advancement was reported in Bioorganic & Medicinal Chemistry Letters (2024), where researchers utilized 1-methylpiperidin-4-amine to develop potent acetylcholinesterase (AChE) inhibitors. These inhibitors showed promising results in preclinical models of Alzheimer's disease, with improved blood-brain barrier permeability compared to existing therapeutics. The study emphasized the compound's role in enhancing drug-like properties of small-molecule inhibitors.

In the field of chemical biology, a recent Nature Communications paper (2024) detailed the use of 1-methylpiperidin-4-amine as a versatile scaffold for designing protein degradation agents. By incorporating this moiety into proteolysis-targeting chimeras (PROTACs), researchers achieved selective degradation of oncogenic proteins in cancer cell lines. This approach opens new avenues for targeted cancer therapy with reduced off-target effects.

The synthesis and scale-up of 1-methylpiperidin-4-amine have also seen improvements. A 2023 publication in Organic Process Research & Development described a novel catalytic reductive amination method that increases yield to 85% while reducing hazardous byproducts. This green chemistry approach addresses previous challenges in industrial-scale production of this important intermediate.

Ongoing clinical trials (as of Q2 2024) are investigating several drug candidates containing the 1-methylpiperidin-4-amine scaffold. Phase I results for a new antipsychotic compound (PM-4012) showed favorable pharmacokinetics and safety profiles. Additionally, preclinical data for a series of antimicrobial agents derived from this structure demonstrate activity against drug-resistant bacterial strains, including MRSA and ESBL-producing Enterobacteriaceae.

Future research directions include exploring the compound's potential in radiopharmaceuticals, as preliminary studies indicate its utility in PET tracer development for neurological imaging. The versatility of 1-methylpiperidin-4-amine continues to make it a valuable asset in medicinal chemistry, with emerging applications across multiple therapeutic areas.

41838-46-4 (1-methylpiperidin-4-amine) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:41838-46-4)1-methylpiperidin-4-amine
A6873
Purity:99%/99%/99%
Quantity:100g/500g/1000g
Price ($):175.0/789.0/1420.0
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