Cas no 41625-30-3 (1,8-Bis(diphenylphosphino)octane)

1,8-Bis(diphenylphosphino)octane is a bidentate diphosphine ligand featuring an eight-carbon alkyl chain linking two diphenylphosphino groups. This structure provides flexibility and an optimal bite angle for coordinating transition metals, making it valuable in homogeneous catalysis. The extended linker enhances steric tolerance, facilitating the formation of stable metal complexes with improved reactivity and selectivity. Its robust coordination properties are advantageous in cross-coupling reactions, hydrogenation, and hydroformylation processes. The ligand's stability under various reaction conditions and its ability to modulate electronic and steric environments contribute to its utility in designing efficient catalytic systems. Its synthesis and handling require standard inert atmosphere techniques due to air sensitivity.
1,8-Bis(diphenylphosphino)octane structure
41625-30-3 structure
Product Name:1,8-Bis(diphenylphosphino)octane
CAS No:41625-30-3
MF:C32H36P2
MW:482.575770378113
MDL:MFCD09834841
CID:927162
PubChem ID:15303439
Update Time:2025-07-02

1,8-Bis(diphenylphosphino)octane Chemical and Physical Properties

Names and Identifiers

    • 1,8-Bis(diphenylphosphino)octane
    • 1,5-Bis(diphenylphosphino)octane
    • 8-diphenylphosphanyloctyl(diphenyl)phosphane
    • 1,8-bis(diphenyl-phosphino)-octane
    • AG-F-48001
    • AGN-PC-00OTTG
    • AK119087
    • CTK1D3724
    • KB-216623
    • SC11231
    • [8-(DIPHENYLPHOSPHANYL)OCTYL]DIPHENYLPHOSPHANE
    • DTXSID50571154
    • MFCD09834841
    • (Octane-1,8-diyl)bis(diphenylphosphane)
    • SCHEMBL5838521
    • 1,5-bis-(Diphenylphosphino)octane
    • E78501
    • 1,8-bis(diphenylphosphino) octane
    • CS-0087835
    • 41625-30-3
    • MDL： MFCD09834841
    • Inchi： 1S/C32H36P2/c1(3-17-27-33(29-19-9-5-10-20-29)30-21-11-6-12-22-30)2-4-18-28-34(31-23-13-7-14-24-31)32-25-15-8-16-26-32/h5-16,19-26H,1-4,17-18,27-28H2
    • InChI Key： BABUPOVYOOZOAE-UHFFFAOYSA-N
    • SMILES： P(C1C=CC=CC=1)(C1C=CC=CC=1)CCCCCCCCP(C1C=CC=CC=1)C1C=CC=CC=1

Computed Properties

  • Exact Mass: 482.22900
  • Monoisotopic Mass: 482.22922514g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 0
  • Heavy Atom Count: 34
  • Rotatable Bond Count: 13
  • Complexity: 413
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 8.4
  • Topological Polar Surface Area: 0?2

Experimental Properties

  • Color/Form: Not available
  • Density: Not available
  • Melting Point: 103-105 oC
  • Boiling Point: 585.6±33.0 °C at 760 mmHg
  • Flash Point: 328.1±31.7 °C
  • Solubility: Insuluble (4.83E-7 g/L) (25 oC),
  • PSA: 27.18000
  • LogP: 7.59280
  • Solubility: Not available
  • Vapor Pressure: 0.0±1.6 mmHg at 25°C

1,8-Bis(diphenylphosphino)octane Security Information

1,8-Bis(diphenylphosphino)octane Customs Data

  • HS CODE：2902909090
  • Customs Data：

    China Customs Code:

    2902909090

    Overview:

    2902909090. Other aromatic hydrocarbons. VAT:17.0%. Tax refund rate:9.0%. Regulatory conditions:nothing. MFN tariff:2.0%. general tariff:30.0%

    Declaration elements:

    Product Name, component content

    Summary:

    2902909090 other aromatic hydrocarbons.Supervision conditions:None.VAT:17.0%.Tax rebate rate:9.0%.MFN tariff:2.0%.General tariff:30.0%

1,8-Bis(diphenylphosphino)octane Pricemore >>

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1,8-Bis(diphenylphosphino)octane Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:41625-30-3)1,8-Bis(diphenylphosphino)octane
Order Number:A1203243
Stock Status:in Stock
Quantity:5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 02:49
Price ($):478.0

1,8-Bis(diphenylphosphino)octane Related Literature

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Additional information on 1,8-Bis(diphenylphosphino)octane

Recent Advances in the Application of 1,8-Bis(diphenylphosphino)octane (CAS: 41625-30-3) in Chemical Biology and Pharmaceutical Research

The compound 1,8-Bis(diphenylphosphino)octane (CAS: 41625-30-3) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications as a ligand in transition metal catalysis and its potential in drug discovery. This research brief aims to summarize the latest findings and advancements related to this compound, highlighting its structural properties, synthetic utility, and emerging roles in biomedical applications.

Recent studies have demonstrated that 1,8-Bis(diphenylphosphino)octane serves as an effective bidentate ligand for palladium and platinum complexes, which are widely used in cross-coupling reactions. A 2023 publication in the Journal of the American Chemical Society reported its use in the synthesis of novel organometallic compounds with enhanced catalytic activity for C-C bond formation. The study emphasized the compound's ability to stabilize reactive intermediates, thereby improving reaction yields and selectivity.

In the pharmaceutical domain, researchers have explored the potential of 1,8-Bis(diphenylphosphino)octane as a scaffold for developing anticancer agents. A preclinical study published in Bioorganic & Medicinal Chemistry Letters revealed that derivatives of this compound exhibited promising cytotoxicity against several cancer cell lines, including breast and lung carcinomas. The mechanism of action appears to involve the disruption of cellular redox homeostasis, leading to apoptosis.

Further investigations into the compound's physicochemical properties have also been conducted. A 2024 study in Chemical Communications utilized advanced spectroscopic techniques to elucidate the conformational flexibility of 1,8-Bis(diphenylphosphino)octane in solution. The findings suggest that its dynamic behavior plays a critical role in modulating the reactivity of metal complexes formed with this ligand.

Looking ahead, the integration of 1,8-Bis(diphenylphosphino)octane into nanotechnology applications represents an exciting frontier. Preliminary data from a collaborative research project indicate its potential use in the fabrication of metal-organic frameworks (MOFs) for targeted drug delivery systems. These developments underscore the compound's multifaceted utility and its growing importance in both fundamental and applied research.

In conclusion, 1,8-Bis(diphenylphosphino)octane (CAS: 41625-30-3) continues to be a valuable tool in chemical biology and pharmaceutical research. Its applications span from catalysis to drug development, with recent studies opening new avenues for innovation. Future research should focus on optimizing its derivatives for enhanced biological activity and exploring its compatibility with emerging technologies such as nanomedicine.

41625-30-3 (1,8-Bis(diphenylphosphino)octane) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:41625-30-3)1,8-Bis(diphenylphosphino)octane
A1203243
Purity:99%
Quantity:5g
Price ($):478.0
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