• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 3. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 4. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 5. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130

Comprehensive Overview of 2-(4-Aminopyridin-2-yl)acetonitrile (CAS No. 415912-70-8): Properties, Applications, and Industry Insights

2-(4-Aminopyridin-2-yl)acetonitrile (CAS No. 415912-70-8) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. This nitrile-functionalized aminopyridine derivative serves as a versatile building block in synthetic chemistry, particularly in the design of heterocyclic compounds. Its molecular formula, C₇H₇N₃, combines a pyridine core with an acetonitrile side chain, creating opportunities for diverse chemical modifications.

Recent advancements in drug discovery have highlighted the importance of 2-(4-Aminopyridin-2-yl)acetonitrile as a precursor for kinase inhibitors and other bioactive molecules. The compound's hydrogen bonding capacity and electron-rich aromatic system make it particularly valuable in medicinal chemistry applications. Researchers are increasingly exploring its potential in developing treatments for chronic diseases, aligning with current trends in personalized medicine and targeted therapies.

From a synthetic perspective, CAS 415912-70-8 demonstrates remarkable stability under various reaction conditions, making it suitable for multistep organic synthesis. Its amino group at the 4-position allows for selective functionalization, while the nitrile moiety offers additional reactivity options. These characteristics have led to growing interest in the compound's application in catalyzed cross-coupling reactions and metal-organic frameworks (MOFs) development.

The analytical characterization of 2-(4-Aminopyridin-2-yl)acetonitrile typically involves advanced techniques such as NMR spectroscopy, mass spectrometry, and HPLC purity analysis. Recent studies have focused on optimizing its synthetic routes to improve yield and reduce environmental impact, reflecting the chemical industry's shift toward green chemistry principles. These developments address common search queries regarding sustainable synthesis methods and process optimization in fine chemical production.

In material science applications, the compound's conjugated π-system has shown promise in the development of organic electronic materials. This aligns with current research trends in flexible electronics and optoelectronic devices, topics frequently searched by materials scientists and engineers. The planar structure of the pyridine ring combined with the polar nitrile group contributes to interesting charge transport properties in molecular assemblies.

Quality control standards for 415912-70-8 typically require rigorous testing for residual solvents and byproducts, reflecting the pharmaceutical industry's emphasis on impurity profiling. This aspect is particularly relevant to professionals searching for information on analytical method validation and ICH guidelines compliance. The compound's stability under various storage conditions is another frequently researched topic, especially for those involved in chemical inventory management.

Recent patent literature reveals growing intellectual property activity surrounding derivatives of 2-(4-Aminopyridin-2-yl)acetonitrile, particularly in areas of cancer therapeutics and neurodegenerative disease research. This correlates with increasing public interest in breakthrough medications and disease-modifying treatments. The compound's structural flexibility allows for the development of novel molecular scaffolds that can address drug resistance challenges, a hot topic in contemporary medical research.

From a commercial perspective, the global market for specialty chemicals like 2-(4-Aminopyridin-2-yl)acetonitrile is experiencing steady growth, driven by demand from contract research organizations and pharmaceutical developers. Supply chain professionals often search for information about custom synthesis services and scale-up production of such intermediates, reflecting the compound's importance in the fine chemicals value chain.

In academic settings, CAS 415912-70-8 has become a valuable teaching tool for demonstrating heterocyclic chemistry principles and retrosynthetic analysis. Educators frequently seek resources on practical synthetic examples that illustrate fundamental concepts while maintaining relevance to current research directions. The compound's balanced complexity makes it ideal for advanced organic chemistry curricula.

Looking forward, research into 2-(4-Aminopyridin-2-yl)acetonitrile derivatives is expected to expand into emerging areas such as proteolysis targeting chimeras (PROTACs) and covalent inhibitor design. These cutting-edge applications address frequently searched topics in next-generation therapeutics and drug discovery technologies. The compound's structural features position it as a key player in the development of innovative treatment modalities.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)