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Chemical Profile of 1H-Indole-3-ethanol,6-methoxy- (CAS No. 41340-31-2)

1H-Indole-3-ethanol,6-methoxy-, identified by its Chemical Abstracts Service (CAS) number 41340-31-2, is a heterocyclic organic compound that has garnered significant attention in the field of pharmaceutical chemistry and bioorganic synthesis. This compound belongs to the indole family, a class of molecules known for their diverse biological activities and structural versatility. The presence of both hydroxyl and methoxy substituents on the indole core imparts unique reactivity and functional properties, making it a valuable scaffold for the development of novel therapeutic agents.

The structural motif of 1H-indole-3-ethanol,6-methoxy- features a benzene ring fused to a pyrrole ring, with an ethyl group attached to the 3-position and a methoxy group at the 6-position. This specific arrangement enhances its potential as a precursor in synthetic chemistry, particularly in the construction of more complex molecules. The hydroxyl group at the 3-position allows for further functionalization via esterification, etherification, or oxidation pathways, while the methoxy group can serve as a protecting group or participate in metal-catalyzed cross-coupling reactions.

In recent years, there has been growing interest in indole derivatives due to their reported pharmacological effects. Studies have demonstrated that modifications within the indole core can modulate interactions with biological targets, leading to applications in areas such as anti-inflammatory, antimicrobial, and anticancer therapies. The compound 1H-indole-3-ethanol,6-methoxy-, with its dual functional groups, represents an intriguing candidate for further exploration in drug discovery.

One of the most compelling aspects of 1H-indole-3-ethanol,6-methoxy- is its role as an intermediate in the synthesis of biologically active molecules. For instance, researchers have leveraged this scaffold to develop analogs with enhanced binding affinity to specific protein targets. The ethyl group at the 3-position provides a handle for further derivatization, enabling the creation of libraries of compounds for high-throughput screening. Such efforts have yielded promising candidates for treating neurological disorders and chronic inflammatory conditions.

The methoxy group at the 6-position also contributes to the compound's versatility. It can be selectively modified under mild conditions without affecting other functional moieties, allowing chemists to tailor the molecule's properties as needed. This level of control is crucial in medicinal chemistry, where subtle changes in structure can significantly impact efficacy and selectivity.

Recent advancements in synthetic methodologies have further expanded the utility of 1H-indole-3-ethanol,6-methoxy-. For example, transition-metal-catalyzed reactions such as palladium-catalyzed coupling reactions have enabled efficient construction of complex indole derivatives from this precursor. These techniques have not only accelerated synthetic routes but also opened new avenues for structural diversification.

In addition to its synthetic value, 1H-indole-3-ethanol,6-methoxy- has been investigated for its potential role in modulating enzyme activity. Preliminary studies suggest that derivatives of this compound may interact with enzymes involved in metabolic pathways relevant to cancer progression. By targeting these enzymes, such compounds could disrupt aberrant signaling networks and restore normal cellular function.

The pharmacokinetic properties of 1H-indole-3-ethanol,6-methoxy- are also under scrutiny. Researchers are examining how structural features influence absorption, distribution, metabolism, and excretion (ADME) profiles. Understanding these relationships is critical for optimizing drug candidates and improving their clinical efficacy.

The growing body of literature on indole derivatives underscores their importance as pharmacophores. As synthetic chemists continue to develop innovative methods for constructing these molecules, compounds like 1H-indole-3-ethanol,6-methoxy- will remain at the forefront of drug discovery efforts.

In conclusion,1H-indole-3-ethanol,6-methoxy- (CAS No.41340-31-2) represents a versatile scaffold with significant potential in pharmaceutical research. Its unique structural features and reactivity make it a valuable building block for developing novel therapeutic agents targeting various diseases.

• 39232-86-5(1H-INDOLE-3-ETHANOL,7-METHOXY-)
• 682802-86-4(2-(6-HYDROXY-3-INDOLYL)ETHYL ALCOHOL)
• 651331-38-3(1H-Indole-3-dodecanol, 6-methoxy-)
• 712-09-4(5-Methoxytryptophol)
• 651331-40-7(1H-Indole-3-hexadecanol, 6-methoxy-)
• 651331-30-5(1H-Indole-3-decanol, 6-methoxy-)
• 154-02-9(5-Hydroxyindole-3-ethanol)
• 41339-61-1(2-(5-BENZYLOXY-1H-INDOL-3-YL)-ETHANOL)
• 651331-39-4(1H-Indole-3-tetradecanol, 6-methoxy-)
• 60965-37-9(4-methoxy-1H-Indole-3-ethanol)