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  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
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  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids and derivatives

Comprehensive Overview of Methyl 5-acetylthiophene-2-carboxylate (CAS No. 4101-81-9): Properties, Applications, and Industry Trends

Methyl 5-acetylthiophene-2-carboxylate (CAS No. 4101-81-9) is a specialized organic compound belonging to the thiophene derivative family. This compound, characterized by its acetyl and carboxylate functional groups, has garnered significant attention in pharmaceutical and material science research due to its versatile reactivity and structural uniqueness. With the rising demand for heterocyclic building blocks in drug discovery, this compound serves as a critical intermediate for synthesizing bioactive molecules, agrochemicals, and advanced materials.

The molecular structure of Methyl 5-acetylthiophene-2-carboxylate combines a thiophene ring with an acetyl group at the 5-position and a methyl ester at the 2-position. This configuration enables diverse chemical transformations, such as nucleophilic substitutions and condensations, making it valuable for constructing complex molecular architectures. Researchers frequently explore its role in polymer chemistry and organic electronics, where thiophene derivatives are pivotal for developing conductive polymers and organic semiconductors.

In recent years, the compound’s relevance has surged alongside trends in green chemistry and sustainable synthesis. As industries seek eco-friendly alternatives, CAS 4101-81-9 is investigated for its potential in catalytic processes and biodegradable material design. Its compatibility with microwave-assisted reactions and flow chemistry techniques aligns with modern lab practices aimed at reducing solvent waste and energy consumption.

From a commercial perspective, Methyl 5-acetylthiophene-2-carboxylate is supplied by leading chemical manufacturers under stringent purity standards (≥98%). Analytical techniques like HPLC, GC-MS, and NMR are employed to verify its quality, ensuring suitability for high-value applications. Storage recommendations typically include protection from moisture and light, with stability data indicating optimal performance when handled under inert conditions.

Frequently asked questions about this compound include: "What are the synthetic routes for Methyl 5-acetylthiophene-2-carboxylate?" or "How does CAS 4101-81-9 compare to other thiophene esters in reactivity?" Addressing these, studies highlight its superiority in Friedel-Crafts acylation efficiency and esterification yields. Additionally, its low toxicity profile makes it preferable for academic and industrial use compared to halogenated analogs.

Emerging applications in OLED technology and photovoltaic cells further elevate the compound’s profile. Its electron-rich thiophene core enhances charge transport properties, a feature exploited in next-gen optoelectronic devices. Collaborative research between academia and corporations continues to uncover novel uses, reinforcing its status as a high-potential intermediate.

To summarize, Methyl 5-acetylthiophene-2-carboxylate (CAS No. 4101-81-9) represents a convergence of synthetic utility and innovation-driven demand. Its adaptability across multiple disciplines—from medicinal chemistry to renewable energy—positions it as a compound of enduring scientific and commercial interest.

• 501441-81-2(2-Thiophenecarboxylic acid, 5-(1-hydroxyethyl)-, methyl ester)
• 67137-62-6(2-THIOPHENECARBOXYLIC ACID, 5-(4-OXOPENTYL)-, METHYL ESTER)
• 844502-29-0(2-THIOPHENECARBOXYLIC ACID, 5-ACETYL-, 1,1-DIMETHYLETHYL ESTER)
• 160744-13-8(Methyl 5-(2-hydroxyethyl)thiophene-2-carboxylate)
• 33148-82-2(ethyl 5-acetylthiophene-2-carboxylate)
• 155187-59-0(2-Thiophenecarboxylic acid, 5-[1-(5-acetyl-2-thienyl)ethyl]-, methyl ester)
• 155187-63-6(2-Thiophenecarboxylic acid, 5-[1-[5-(2-thienylcarbonyl)-2-thienyl]ethyl]-, methyl ester)
• 91086-68-9(2-THIOPHENECARBOXYLIC ACID, 5-ETHYL-, METHYL ESTER)
• 890100-51-3(Ethyl 5-thenoyl-2-thiophene carboxylate)
• 229003-19-4(2-Thiophenecarboxylic acid, 5-(1,1-dimethylethyl)-, methyl ester)