• 1. Development of an indirect competitive enzyme-linked immunosorbent assay for screening ethopabate residue in chicken muscle and liver
  Zhaozhou Li,Yao Wang,Daomin Li,Xiujin Chen,Zhili Li,Hongli Gao,Li Cao,Songbiao Li,Yuze Hou RSC Adv. 2017 7 36072

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Acylaminobenzoic acid and derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Acylaminobenzoic acid and derivatives

Comprehensive Overview of Methyl 4-acetamido-2-methoxybenzoate (CAS No. 4093-29-2): Properties, Applications, and Industry Insights

Methyl 4-acetamido-2-methoxybenzoate (CAS No. 4093-29-2) is a specialized organic compound widely recognized in pharmaceutical and fine chemical industries. This ester derivative, featuring both acetamido and methoxy functional groups, exhibits unique physicochemical properties that make it valuable for synthetic applications. With a molecular formula of C₁₁H₁₃NO₄, it is often utilized as an intermediate in the synthesis of bioactive molecules, including non-steroidal anti-inflammatory drugs (NSAIDs) and flavoring agents.

The compound’s solubility in organic solvents and thermal stability have spurred interest in its use for green chemistry applications, aligning with the global push for sustainable synthesis methods. Researchers frequently explore its role in catalyzed reactions, particularly in palladium-coupling and enzymatic esterification processes. Recent studies highlight its potential in drug delivery systems, where its low toxicity profile and controlled release properties are advantageous.

In the context of cosmetic science, Methyl 4-acetamido-2-methoxybenzoate has been investigated for its mild UV-absorbing characteristics, though it is not a primary sunscreen agent. Its benzoate backbone contributes to its compatibility with skincare formulations, making it a subject of interest for anti-aging and moisturizing products. However, regulatory compliance, such as REACH and FDA guidelines, must be considered for commercial use.

From an industrial perspective, the compound’s synthesis typically involves esterification of 4-acetamido-2-methoxybenzoic acid with methanol under acidic conditions. Optimizing reaction yield and purity remains a focus, with advancements in continuous flow chemistry offering scalable solutions. Analytical techniques like HPLC and NMR spectroscopy are critical for quality control, ensuring compliance with pharmacopeial standards.

Emerging trends in personalized medicine and bioconjugation have further elevated the relevance of 4093-29-2. Its structural flexibility allows for modifications to enhance bioavailability or target-specific interactions, addressing demands in oncology and neurology research. Additionally, its role in food preservatives and fragrance stabilization underscores its versatility across sectors.

Environmental and safety assessments of Methyl 4-acetamido-2-methoxybenzoate emphasize its biodegradability and eco-friendly disposal protocols. While it is not classified as hazardous, proper storage conditions (e.g., away from strong oxidizers) and handling precautions (e.g., PPE) are recommended to maintain workplace safety. Regulatory databases such as PubChem and ChemSpider provide extensive toxicological data for risk evaluation.

In summary, CAS No. 4093-29-2 represents a multifaceted compound bridging pharmaceutical innovation and industrial applications. Its adaptability to green synthesis, coupled with expanding roles in life sciences, positions it as a compound of enduring significance. Future research may uncover novel derivatives or hybrid molecules leveraging its core structure for next-generation therapeutics and functional materials.

• 5003-48-5(Benorilate)
• 59-06-3(Ethopabate)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)