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  Jason Wan Lab Chip, 2020,20, 4528-4538
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Monosaccharides
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Monosaccharides

Exploring D-Glucose,2-(acetylamino)-2,6-dideoxy- (CAS No. 40614-71-9): Properties, Applications, and Research Insights

D-Glucose,2-(acetylamino)-2,6-dideoxy- (CAS No. 40614-71-9) is a specialized carbohydrate derivative that has garnered significant attention in biochemical and pharmaceutical research. This compound, often referred to as a modified sugar, plays a crucial role in understanding glycosylation processes and developing novel therapeutic agents. Its unique structure, featuring an acetylamino group and deoxygenation at positions 2 and 6, makes it a valuable tool for studying carbohydrate-protein interactions.

The growing interest in D-Glucose derivatives is partly driven by advancements in glycobiology and the search for bioactive molecules. Researchers are particularly intrigued by how modifications like 2,6-dideoxygenation influence the compound's biological activity. Recent studies suggest that D-Glucose,2-(acetylamino)-2,6-dideoxy- may have potential applications in drug development, especially in creating targeted therapies for metabolic disorders.

From a chemical perspective, CAS 40614-71-9 represents an interesting case study in carbohydrate chemistry. The introduction of the acetylamino moiety at the 2-position significantly alters the molecule's hydrogen bonding capacity, while the 6-deoxy modification affects its conformational flexibility. These structural features make it a valuable reference compound for NMR studies and molecular modeling of sugar-protein interactions.

The synthesis of 2-(acetylamino)-2,6-dideoxy-D-glucose typically involves selective protection and deoxygenation strategies, highlighting the sophistication of modern carbohydrate chemistry. Current research trends focus on optimizing these synthetic pathways to improve yields and scalability, responding to the increasing demand for well-defined carbohydrate standards in analytical laboratories.

In the pharmaceutical sector, interest in modified monosaccharides like D-Glucose,2-(acetylamino)-2,6-dideoxy- has surged due to their potential as glycosylation inhibitors. These compounds are being investigated for their ability to modulate cellular recognition processes, with implications for developing anti-inflammatory and immunomodulatory agents. The compound's structural similarity to natural sugar substrates makes it particularly interesting for studying metabolic pathways.

Analytical applications of CAS 40614-71-9 are equally noteworthy. As a reference standard, it helps in the characterization of complex carbohydrates and glycoconjugates. Mass spectrometry and HPLC methods frequently employ this compound for method development and validation, especially in glycomics research where precise identification of sugar modifications is crucial.

The stability and storage conditions of D-Glucose,2-(acetylamino)-2,6-dideoxy- are important considerations for researchers. Proper handling typically requires protection from moisture and storage at controlled temperatures to maintain its chemical integrity. These practical aspects are frequently addressed in technical documentation and material safety data sheets provided by suppliers.

Market trends indicate growing demand for specialized carbohydrates like 2-(acetylamino)-2,6-dideoxy-D-glucose, particularly from research institutions and biotechnology companies. The compound's price and availability can vary significantly depending on purity requirements and supplier capabilities, making supplier selection an important consideration for procurement specialists.

Future research directions for D-Glucose,2-(acetylamino)-2,6-dideoxy- may explore its potential in glycoconjugate vaccine development and as a building block for synthetic oligosaccharides. The compound's unique structural features position it as a valuable tool for advancing our understanding of carbohydrate-mediated biological processes and developing new biomedical applications.

• 94725-25-4(D-Mannose-6,6-C-t2,2-(acetylamino)-2-deoxy- (9CI))
• 4773-29-9(Mannose,2-(acetylamino)-2-deoxy-)
• 7220-89-5(acetyl-d-glucosamine, n-[glucosamine-1-14c])
• 20880-45-9(2-ACETAMIDO-2-DEOXY-D-ALLOSE)
• 127959-06-2(2-ACETAMIDO-2-DEOXY-D-[UL-13C6]GLUCOSE)
• 98632-70-3(N-Acetyl-D-Glucosamine)
• 1811-31-0(N-Acetyl-D-galactosamine)
• 35233-39-7(2-Acetamido-2,6-dideoxy-D-galactose)
• 134451-94-8(2-Acetamido-2-deoxy-L-glucopyranose)
• 78393-48-3(N-((2R,3R,4R,5R)-3,4,5,6-Tetrahydroxy-1-oxohexan-2-yl)acetamide)