• 1. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 2. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 3. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 4. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 5. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylhydrazines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

3,4-Difluorophenylhydrazine Hydrochloride: A Comprehensive Overview

3,4-Difluorophenylhydrazine hydrochloride, with the CAS number 40594-37-4, is a chemical compound that has garnered significant attention in various fields of scientific research. This compound is a derivative of phenylhydrazine, with two fluorine atoms substituted at the 3 and 4 positions of the benzene ring. The hydrochloride form indicates that it exists as a salt with hydrochloric acid. This compound is widely recognized for its unique chemical properties and its potential applications in pharmaceuticals, agrochemicals, and materials science.

The synthesis of 3,4-Difluorophenylhydrazine hydrochloride typically involves the reaction of 3,4-difluoroaniline with hydrazine in the presence of an acid catalyst. The reaction conditions are optimized to ensure high yield and purity. Recent advancements in synthetic methodologies have enabled researchers to explore more efficient and environmentally friendly routes for the production of this compound. For instance, microwave-assisted synthesis has been reported to significantly reduce reaction time while maintaining product quality.

3,4-Difluorophenylhydrazine hydrochloride exhibits interesting pharmacological properties, making it a valuable tool in drug discovery. Studies have shown that this compound can act as a potential lead molecule for the development of anti-inflammatory and anticancer agents. Its ability to inhibit specific enzymes involved in inflammatory pathways has been extensively investigated. Furthermore, preclinical studies suggest that it may possess selective cytotoxicity against cancer cells, which could be exploited for targeted therapy.

In the field of agrochemistry, 3,4-Difluorophenylhydrazine hydrochloride has been explored as a component in herbicides and fungicides. Its ability to interfere with key metabolic pathways in plant pathogens makes it a promising candidate for crop protection. Recent research has focused on enhancing its bioavailability and stability under field conditions to improve its efficacy as an agricultural chemical.

The structural uniqueness of 3,4-Difluorophenylhydrazine hydrochloride also lends itself to applications in materials science. It has been used as a precursor in the synthesis of advanced materials such as coordination polymers and metal-organic frameworks (MOFs). These materials exhibit exceptional properties such as high surface area and tunable pore sizes, which are valuable for gas storage and catalysis applications.

In terms of environmental impact, studies have been conducted to assess the biodegradation and toxicity of 3,4-Difluorophenylhydrazine hydrochloride. Results indicate that it undergoes rapid microbial degradation under aerobic conditions, reducing its persistence in the environment. However, further research is needed to evaluate its long-term effects on aquatic ecosystems.

The demand for 3,4-Difluorophenylhydrazine hydrochloride continues to grow due to its versatile applications across multiple industries. As technology advances and new research findings emerge, this compound is expected to play an even more significant role in driving innovation in chemistry and related fields.

• 828-73-9(Pentafluorophenylhydrazine)
• 4920-37-0(Hydrazine,(2,3,6-trifluorophenyl)-)
• 823-85-8((4-fluorophenyl)hydrazine hydrochloride)
• 502496-27-7(3,5-Difluorophenylhydrazine hydrochloride)
• 134993-88-7((3,5-Difluorophenyl)hydrazine)
• 161886-22-2((3,4-Difluorophenyl)hydrazine)
• 371-14-2((4-Fluorophenyl)hydrazine)
• 2924-16-5(3-Fluorophenylhydrazine hydrochloride)
• 653-11-2(2,3,5,6-tetrafluorophenylhydrazine)
• 875664-54-3(3,4-Difluorophenylhydrazine hydrochloride)