• 1. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 2. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 3. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 4. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 5. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622

Comprehensive Overview of cis-Cyclopentane-1,2-diamine (CAS No. 40535-45-3): Properties, Applications, and Industry Insights

cis-Cyclopentane-1,2-diamine (CAS No. 40535-45-3) is a specialized chiral diamine compound with a cyclopentane backbone, widely recognized for its role in asymmetric synthesis and pharmaceutical intermediates. Its stereospecific configuration (cis- form) makes it invaluable in catalysis, ligand design, and fine chemical production. This article explores its molecular characteristics, industrial relevance, and emerging trends aligned with green chemistry and AI-driven drug discovery—topics currently dominating scientific discourse.

The molecular structure of cis-cyclopentane-1,2-diamine features two amino groups on the same side of the cyclopentane ring, enabling unique chelation properties. With a molar mass of 114.19 g/mol and a density of ~0.98 g/cm3, it exhibits solubility in polar solvents like water and ethanol. Researchers frequently highlight its enantiomeric purity (>98%), critical for applications in chiral auxiliaries and metal-organic frameworks (MOFs). Recent studies also emphasize its potential in biodegradable polymers, addressing the global demand for sustainable materials.

In pharmaceuticals, CAS 40535-45-3 serves as a precursor for anticancer agents and enzyme inhibitors. Its ability to form stable complexes with transition metals (e.g., Ru, Pd) has spurred innovations in homogeneous catalysis, particularly in C–H activation reactions—a hot topic in organic synthesis. A 2023 Journal of Medicinal Chemistry report linked derivatives of this compound to targeted drug delivery systems, resonating with the rise of personalized medicine.

From an industrial perspective, manufacturers optimize cis-cyclopentane-1,2-diamine production via stereoselective hydrogenation or enzymatic resolution, reflecting the shift toward low-waste processes. The compound’s thermal stability (decomposes at ~250°C) ensures compatibility with high-temperature applications, such as epoxy resin hardeners in aerospace composites. Notably, its low toxicity profile (LD50 > 2000 mg/kg, oral) aligns with REACH compliance, a key concern for EU exporters.

Emerging trends integrate computational chemistry to predict cis-cyclopentane-1,2-diamine reactivity, leveraging machine learning algorithms—a frequent search query among chemists. Patents filed in 2024 reveal its utility in CO2 capture technologies, tapping into climate change mitigation efforts. Furthermore, its scalable synthesis meets the demand for cost-effective chiral building blocks, as highlighted in ACS Sustainable Chemistry & Engineering.

To address common user queries: Unlike linear diamines, cyclopentane-based diamines offer enhanced ring strain for selective reactions. FAQs often discuss its NMR spectra (δ 1.5–2.1 ppm for cyclic protons) and HPLC analysis methods. Storage recommendations include inert atmospheres to prevent oxidative degradation, while suppliers emphasize batch-to-batch consistency for GMP applications.

In summary, cis-cyclopentane-1,2-diamine (CAS No. 40535-45-3) bridges academic research and industrial innovation. Its versatility in asymmetric catalysis, material science, and life sciences positions it as a compound of enduring significance, particularly amid the push for eco-friendly synthesis and high-throughput screening technologies.

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• 10443-36-4(1,2-Propanediamine,N1-dodecyl-)
• 115964-47-1(4,5-Nonanediamine)
• 3145-88-8(trans-cyclopentane-1,2-diamine)
• 175415-00-6(1,2-Cycloheptanediamine,(1S-trans)- (9CI))
• 77255-03-9((1S,2S)-cyclopentane-1,2-diamine)
• 477873-22-6((1S,2S)-Cyclopentane-1,2-diamine dihydrochloride)
• 632325-03-2(1,2-Cyclopentanediamine,conjugatemonoacid,(1R,2S)-rel-(9CI))
• 230312-98-8((1R,2R)-cycloheptane-1,2-diamine)
• 41330-23-8(Cyclopentane-1,2-diamine)