• 1. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 2. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 3. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 4. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 5. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Hexanoic acid, 3-amino-4-methyl-, (3S,4S)-: A Comprehensive Overview in Modern Chemical Research

Hexanoic acid, 3-amino-4-methyl-, (3S,4S)-, with the CAS number 40469-87-2, is a compound of significant interest in the field of chemical biology and pharmaceutical research. This molecule, characterized by its unique stereochemistry and functional groups, has garnered attention for its potential applications in drug development and synthetic chemistry. The presence of both an amino group and a carboxylic acid moiety, along with the specific (3S,4S) configuration, makes it a versatile intermediate in the synthesis of more complex molecules.

The compound's structure is derived from hexanoic acid, which is a six-carbon saturated fatty acid. The introduction of an amino group at the 3-position and a methyl group at the 4-position introduces additional reactivity and functionality. This modification not only alters the physical properties of the molecule but also opens up possibilities for its use in various chemical reactions, including condensation reactions, nucleophilic substitutions, and enzymatic transformations.

In recent years, there has been growing interest in chiral compounds due to their role in biological systems and pharmaceuticals. The stereochemistry of Hexanoic acid, 3-amino-4-methyl-, (3S,4S)- is particularly noteworthy because enantiomers can exhibit different biological activities. This has led to extensive research into methods for the efficient synthesis and resolution of such chiral compounds. Advanced techniques such as asymmetric synthesis and chiral auxiliary methods have been employed to achieve high enantiomeric purity.

The compound's potential applications extend to the field of drug discovery. The combination of an amino group and a carboxylic acid group allows for easy derivatization into amides, esters, and other pharmacologically relevant structures. For instance, amides derived from this compound have shown promise as intermediates in the synthesis of bioactive molecules targeting various therapeutic areas. Recent studies have highlighted its utility in the development of novel antibiotics and anti-inflammatory agents.

One particularly exciting area of research involves the use of Hexanoic acid, 3-amino-4-methyl-, (3S,4S)- as a building block for peptidomimetics. Peptidomimetics are designed to mimic the biological activity of natural peptides but with improved stability and pharmacokinetic properties. The unique structural features of this compound make it an excellent candidate for creating peptidomimetic cores that can interact with biological targets in a specific manner. This approach has been successful in developing treatments for diseases such as cancer and neurodegenerative disorders.

The synthesis of Hexanoic acid, 3-amino-4-methyl-, (3S,4S)- presents both challenges and opportunities. Traditional synthetic routes often require multiple steps and can be inefficient in terms of yield and scalability. However, recent advancements in synthetic methodology have provided more streamlined approaches. For example, biocatalytic methods using engineered enzymes have been explored as a means to achieve high enantiomeric purity with minimal environmental impact. These green chemistry approaches align with the growing emphasis on sustainable practices in chemical synthesis.

The analytical characterization of this compound is another critical aspect of its study. Techniques such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and X-ray crystallography are routinely employed to confirm its structure and purity. These analytical methods not only provide detailed information about the molecular structure but also help in understanding its reactivity and interactions with other molecules.

In conclusion, Hexanoic acid, 3-amino-4-methyl-, (3S,4S)- represents a fascinating molecule with significant potential in chemical biology and pharmaceutical research. Its unique structural features and stereochemistry make it a valuable intermediate for synthesizing complex bioactive molecules. As research continues to uncover new applications for this compound, it is likely to play an increasingly important role in the development of novel therapeutics.

• 446259-39-8((3S,4R)-3-amino-4-methylhexanoic acid)
• 849488-35-3(HEPTANOIC ACID, 3-AMINO-4,5-DIETHYL-6-METHYL-)
• 849488-53-5(HEPTANOIC ACID, 3-AMINO-4,5-DIMETHYL-, (3R,4R,5R)-)
• 776330-71-3(3-amino-3-cycloheptylpropanoic acid)
• 849488-30-8(HEPTANOIC ACID, 3-AMINO-4,5-DIETHYL-)
• 849489-04-9(DECANOIC ACID, 3-AMINO-4-ETHYL-6-METHYL-)
• 103905-71-1(Octanoic acid,3-amino-4-ethyl-)
• 75946-24-6((3R,4S)-3-amino-4-methylhexanoic acid)
• 849488-18-2(HEPTANOIC ACID, 3-AMINO-4,5-DIMETHYL-)
• 849488-55-7(DECANOIC ACID, 3-AMINO-4,5-DIMETHYL-, (3R,4R,5R)-)