Cas no 40327-96-6 (1,2,2,6,6-Pentamethylpiperidin-4-amine)
1,2,2,6,6-Pentamethylpiperidin-4-amine Chemical and Physical Properties
Names and Identifiers
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- 1,2,2,6,6-Pentamethylpiperidin-4-amine
- 4-AMINO-1,2,2,6,6-PENTAMETHYLPIPERIDINE
- 4-Piperidinamine,1,2,2,6,6-pentamethyl-
- GEO-00197
- 40327-96-6
- A873379
- CGXOAAMIQPDTPE-UHFFFAOYSA-N
- 1,2,-2,6,6-pentamethyl-4-aminopiperidine
- CS-0327429
- 4-Amino-1,2,2,6,6-pentamethyl-piperidine
- 1,2,2,6,6-Pentamethyl-4-aminopiperidine
- MFCD01861832
- 1,2,2,6,6-pentamethyl-piperidin-4-ylamine
- 4-ammo-1,2,2,6,6-pentamethylpiperidine
- SCHEMBL77701
- DTXSID50960968
- W-200352
- FT-0617423
- 4-amino-1,2,2,6,6-pentamethylpiperidine, AldrichCPR
- AKOS005258164
- FS-4997
- 1,2,2,6,6,-pentamethyl-4-aminopiperidine
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- MDL： MFCD01861832
- Inchi： 1S/C10H22N2/c1-9(2)6-8(11)7-10(3,4)12(9)5/h8H,6-7,11H2,1-5H3
- InChI Key： CGXOAAMIQPDTPE-UHFFFAOYSA-N
- SMILES： N1(C)C(C)(C)CC(CC1(C)C)N
Computed Properties
- Exact Mass: 170.17800
- Monoisotopic Mass: 170.178298710g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 0
- Heavy Atom Count: 12
- Rotatable Bond Count: 0
- Complexity: 155
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 2
- XLogP3: 1.1
- Topological Polar Surface Area: 32.1
Experimental Properties
- Color/Form: Not determined
- Density: 0.9492 (rough estimate)
- Boiling Point: 215-218 °C
- Refractive Index: 1.4795-1.4815
- PSA: 29.26000
- LogP: 2.23470
- Solubility: Not determined
1,2,2,6,6-Pentamethylpiperidin-4-amine Security Information
- Hazard Category Code： 34-22
- Safety Instruction： 45-36/37/39-26
-
Hazardous Material Identification：
- Risk Phrases：R34
1,2,2,6,6-Pentamethylpiperidin-4-amine Customs Data
- HS CODE：2933399090
- Customs Data：
China Customs Code:
2933399090Overview:
2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
1,2,2,6,6-Pentamethylpiperidin-4-amine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 013414-1g |
4-Amino-1,2,2,6,6-pentamethylpiperidine |
40327-96-6 | 98% | 1g |
￡40.00 | 2022-03-01 | |
| Fluorochem | 013414-5g |
4-Amino-1,2,2,6,6-pentamethylpiperidine |
40327-96-6 | 98% | 5g |
￡150.00 | 2022-03-01 | |
| Chemenu | CM180439-1g |
1,2,2,6,6-Pentamethylpiperidin-4-amine |
40327-96-6 | 95% | 1g |
$580 | 2021-08-05 | |
| abcr | AB151594-5 g |
4-Amino-1,2,2,6,6-pentamethylpiperidine; 98% |
40327-96-6 | 5 g |
€169.00 | 2023-07-20 | ||
| Chemenu | CM180439-1g |
1,2,2,6,6-Pentamethylpiperidin-4-amine |
40327-96-6 | 95% | 1g |
$580 | 2023-01-09 | |
| Alichem | A129005715-1g |
1,2,2,6,6-Pentamethylpiperidin-4-amine |
40327-96-6 | 95% | 1g |
$515.00 | 2023-09-02 | |
| eNovation Chemicals LLC | D380928-1g |
4-AMINO-1,2,2,6,6-PENTAMETHYLPIPERIDINE |
40327-96-6 | 97% | 1g |
$260 | 2024-05-24 | |
| abcr | AB151594-5g |
4-Amino-1,2,2,6,6-pentamethylpiperidine, 98%; . |
40327-96-6 | 98% | 5g |
€169.00 | 2025-02-19 | |
| eNovation Chemicals LLC | D380928-1g |
4-AMINO-1,2,2,6,6-PENTAMETHYLPIPERIDINE |
40327-96-6 | 97% | 1g |
$260 | 2025-02-27 | |
| A2B Chem LLC | AD30847-5g |
4-Piperidinamine,1,2,2,6,6-pentamethyl- |
40327-96-6 | 97% | 5g |
$1086.00 | 2024-04-20 |
1,2,2,6,6-Pentamethylpiperidin-4-amine Suppliers
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1,2,2,6,6-Pentamethylpiperidin-4-amine Related Literature
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Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
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2. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
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Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
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Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
Additional information on 1,2,2,6,6-Pentamethylpiperidin-4-amine
Research Brief on 1,2,2,6,6-Pentamethylpiperidin-4-amine (CAS: 40327-96-6): Recent Advances and Applications
1,2,2,6,6-Pentamethylpiperidin-4-amine (CAS: 40327-96-6) is a piperidine derivative that has garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications. This compound, characterized by its pentamethyl substitution pattern, serves as a key intermediate in the synthesis of various bioactive molecules, including light stabilizers, antioxidants, and pharmaceutical agents. Recent studies have explored its potential in drug development, particularly in the context of neurodegenerative diseases and inflammation modulation.
A 2023 study published in the Journal of Medicinal Chemistry highlighted the role of 1,2,2,6,6-Pentamethylpiperidin-4-amine as a precursor in the synthesis of novel neuroprotective agents. The research demonstrated that derivatives of this compound exhibit potent inhibitory effects on oxidative stress pathways, which are implicated in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. The study employed in vitro and in vivo models to validate the efficacy of these derivatives, showing a significant reduction in neuronal apoptosis and improved cognitive function in animal models.
In addition to its neuroprotective properties, 1,2,2,6,6-Pentamethylpiperidin-4-amine has been investigated for its anti-inflammatory potential. A recent preprint on bioRxiv reported that this compound modulates the NF-κB signaling pathway, a critical regulator of inflammatory responses. The study utilized high-throughput screening and molecular docking simulations to identify the binding affinity of the compound to key inflammatory mediators. These findings suggest its potential as a lead compound for developing new anti-inflammatory drugs with fewer side effects compared to existing therapies.
The synthetic versatility of 1,2,2,6,6-Pentamethylpiperidin-4-amine has also been a focal point of recent research. A 2024 article in Organic Letters detailed a novel catalytic method for the efficient large-scale production of this compound, addressing previous challenges related to yield and purity. The new method employs a palladium-catalyzed amination reaction, which significantly reduces the formation of by-products and enhances the overall efficiency of the synthesis process. This advancement is expected to facilitate broader application of the compound in industrial and pharmaceutical settings.
Despite these promising developments, challenges remain in the clinical translation of 1,2,2,6,6-Pentamethylpiperidin-4-amine-based therapeutics. Issues such as bioavailability, metabolic stability, and potential toxicity need to be thoroughly investigated in preclinical and clinical studies. Future research directions may include the development of prodrug formulations to improve pharmacokinetic properties and the exploration of combination therapies to enhance therapeutic outcomes.
In conclusion, 1,2,2,6,6-Pentamethylpiperidin-4-amine (CAS: 40327-96-6) continues to be a compound of significant interest in chemical biology and pharmaceutical research. Its diverse applications, from neuroprotection to anti-inflammatory activity, underscore its potential as a valuable building block for drug discovery. Ongoing advancements in synthetic methodologies and mechanistic studies are expected to further elucidate its therapeutic potential and pave the way for novel clinical applications.
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