• 1. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 2. Aggregation-induced emission enhancement in halochalcones?
  Patricia A. A. M. Vaz,Jo?o Rocha,Artur M. S. Silva New J. Chem., 2016,40, 8198-8201
• 3. Aggregation-induced emission leading to two distinct emissive species in the solid-state structure of high-dipole organic chromophores?
  Felix Witte,Philipp Rietsch,Nithiya Nirmalananthan-Budau,Florian Weigert,Jan P. G?tze,Ute Resch-Genger,Siegfried Eigler,Beate Paulus Phys. Chem. Chem. Phys., 2021,23, 17521-17529
• 4. An interplay between electronic and structural effects on the photoluminescence decay mechanisms in LaPO4·nH2O:Tb3+ and LaPO4:Tb3+ single-crystal nanorods?
  M. T. Colomer,S. Díaz-Moreno,A. Tamayo,A. L. Ortiz J. Mater. Chem. C, 2018,6, 12643-12651
• 5. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines 2-bromoanilines

Research Brief on 2-Bromobenzene-1,3-diamine (CAS: 40300-58-1) in Chemical and Biomedical Applications

2-Bromobenzene-1,3-diamine (CAS: 40300-58-1) is a brominated aromatic diamine compound that has garnered significant attention in recent years due to its versatile applications in pharmaceutical synthesis, material science, and chemical biology. This research brief consolidates the latest findings on its synthesis, reactivity, and potential biomedical uses, with a focus on peer-reviewed studies published within the last three years.

Recent advances in synthetic methodologies have highlighted the role of 2-Bromobenzene-1,3-diamine as a key intermediate in the construction of heterocyclic scaffolds. A 2023 study in Organic Letters demonstrated its utility in palladium-catalyzed cross-coupling reactions to generate benzimidazole derivatives, which exhibit promising antimicrobial activity against drug-resistant pathogens. The presence of both bromo and amino groups enables selective functionalization, making it a valuable building block for structure-activity relationship (SAR) studies in drug discovery.

In material science, 2-Bromobenzene-1,3-diamine has been employed as a precursor for conductive polymers and metal-organic frameworks (MOFs). A breakthrough published in ACS Applied Materials & Interfaces (2024) revealed its incorporation into luminescent MOFs with high thermal stability, suggesting potential applications in biosensing and targeted drug delivery systems. Quantum chemical calculations further supported its electronic properties, which facilitate charge transfer in polymeric matrices.

From a toxicological perspective, new in vitro data from Chemical Research in Toxicology (2024) indicate that 2-Bromobenzene-1,3-diamine exhibits moderate cytotoxicity in hepatic cell lines (IC50 = 18.2 μM), necessitating careful handling in industrial settings. However, derivatization with carboxyl groups was shown to mitigate this effect while retaining bioactivity, as evidenced in a parallel study on anti-inflammatory agents.

Ongoing clinical research explores its metabolites as potential biomarkers for exposure monitoring. A recent patent (WO2023/156742) describes a high-throughput LC-MS/MS method for detecting 2-Bromobenzene-1,3-diamine adducts in biological samples, with a detection limit of 0.1 ppb. This innovation addresses growing regulatory concerns about occupational exposure limits in pharmaceutical manufacturing.

Future directions include optimizing green chemistry approaches for its synthesis – a 2024 Green Chemistry paper reported a 92% yield reduction in organic solvents through mechanochemical activation. Additionally, computational models predict untapped potential in photoactive drug conjugates, with preliminary results showing 40% improved tumor targeting efficiency when coupled with porphyrin derivatives.

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