• 1. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 3. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 4. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 5. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Introduction to 6-Benzylpyridin-3-amine (CAS No. 40296-80-8)

6-Benzylpyridin-3-amine, identified by the Chemical Abstracts Service Number (CAS No.) 40296-80-8, is a significant compound in the field of pharmaceutical chemistry and medicinal research. This heterocyclic amine derivative has garnered attention due to its versatile structural framework and potential applications in drug development. The benzyl group and the pyridine ring contribute to its unique chemical properties, making it a valuable intermediate in synthesizing biologically active molecules.

The compound belongs to the broader category of pyridine derivatives, which are widely studied for their pharmacological effects. Pyridine-based structures are prevalent in many therapeutic agents due to their ability to interact with biological targets such as enzymes and receptors. Specifically, 6-Benzylpyridin-3-amine exhibits characteristics that make it a promising candidate for further exploration in medicinal chemistry.

In recent years, there has been a surge in research focused on developing novel treatments for various diseases, including cancer, infectious diseases, and neurological disorders. 6-Benzylpyridin-3-amine has been investigated for its potential role in these areas. Its molecular structure allows for modifications that can enhance its binding affinity and selectivity towards specific biological targets. This flexibility makes it an attractive scaffold for designing small-molecule drugs.

One of the most compelling aspects of 6-Benzylpyridin-3-amine is its utility as a building block in the synthesis of more complex pharmacophores. Researchers have leveraged its core structure to develop derivatives with improved pharmacokinetic properties and reduced toxicity. For instance, studies have demonstrated its use in creating inhibitors targeting enzymes involved in cancer progression. The benzyl group provides a handle for further functionalization, enabling chemists to tailor the molecule for specific therapeutic outcomes.

The synthesis of 6-Benzylpyridin-3-amine typically involves multi-step organic reactions, often starting from commercially available precursors such as 3-bromopyridine and benzylamine. Advances in synthetic methodologies have made the production of this compound more efficient and scalable, facilitating its use in both academic and industrial research settings. The optimization of synthetic routes has also led to higher yields and purities, ensuring that researchers have access to high-quality material for their studies.

From a computational chemistry perspective, 6-Benzylpyridin-3-amine has been subjected to extensive molecular modeling studies to understand its interactions with biological targets. These studies have provided insights into how the compound binds to proteins and enzymes, offering a rational basis for designing next-generation drugs. The integration of experimental data with computational predictions has been crucial in refining the pharmacological profile of this derivative.

Another area where 6-Benzylpyridin-3-amine has shown promise is in the development of antimicrobial agents. The growing threat of antibiotic-resistant bacteria has prompted researchers to explore novel chemical entities with antibacterial properties. Pyridine derivatives like 6-Benzylpyridin-3-amine have been found to disrupt bacterial cell wall synthesis and other vital processes, making them potential candidates for new antibiotics.

Furthermore, the compound's ability to cross cell membranes makes it an interesting candidate for drug delivery systems. Researchers are exploring ways to incorporate 6-Benzylpyridin-3-amine into nanoparticles or liposomes to enhance drug delivery efficiency and target specificity. Such innovations could improve therapeutic outcomes by ensuring that drugs reach their intended sites of action more effectively.

The regulatory landscape also plays a crucial role in the development and commercialization of compounds like 6-Benzylpyridin-3-amine. Compliance with Good Manufacturing Practices (GMP) and other regulatory guidelines ensures that pharmaceutical products are safe and effective. As research continues, it is expected that regulatory bodies will provide clearer guidelines on the use of such intermediates in drug development.

In conclusion,6-Benzylpyridin-3-amine (CAS No. 40296-80-8) is a versatile compound with significant potential in pharmaceutical research and drug development. Its unique structural features make it a valuable scaffold for designing novel therapeutic agents targeting various diseases. As research progresses, further applications and advancements are anticipated, solidifying its role as an important intermediate in medicinal chemistry.

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