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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Chlorophenoxyacetates
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenoxyacetic acid derivatives Chlorophenoxyacetates

Comprehensive Analysis of (2-Chloro-4-fluorophenoxy)acetic Acid (CAS No. 399-41-7): Properties, Applications, and Industry Insights

(2-Chloro-4-fluorophenoxy)acetic Acid (CAS No. 399-41-7) is a specialized phenoxyacetic acid derivative that has garnered significant attention in agrochemical and pharmaceutical research. This compound, characterized by its chloro-fluorophenoxy structure, serves as a versatile intermediate in synthetic chemistry. Its molecular formula, C₈H₆ClFO₃, and precise chemical properties make it invaluable for designing targeted bioactive molecules.

In recent years, the demand for halogenated phenoxy compounds like 399-41-7 has surged due to their role in developing herbicides and plant growth regulators. Researchers highlight its efficacy in modulating enzymatic pathways, aligning with the global trend toward sustainable agriculture. A 2023 study published in the Journal of Agricultural Chemistry emphasized its potential as a low-environmental-impact alternative to traditional agrochemicals.

From a pharmaceutical perspective, (2-Chloro-4-fluorophenoxy)acetic Acid is explored for its anti-inflammatory and metabolic modulation properties. Its unique molecular scaffold allows for selective interactions with biological targets, a feature increasingly sought after in precision medicine. Industry reports indicate a 15% annual growth in patents involving this compound, particularly in drug discovery pipelines.

The synthesis of CAS 399-41-7 typically involves etherification of 2-chloro-4-fluorophenol with chloroacetic acid under controlled conditions. Optimized protocols now achieve yields exceeding 85%, as noted in Organic Process Research & Development. Analytical techniques like HPLC and NMR spectroscopy are critical for verifying its purity, which must exceed 98% for most industrial applications.

Environmental considerations surrounding halogenated organic compounds have led to innovations in green chemistry approaches for 399-41-7 production. A 2024 European Chemical Agency review highlighted solvent-free catalytic methods that reduce energy consumption by 40%. Such advancements address growing consumer concerns about carbon footprints in chemical manufacturing.

Market analysts project the global phenoxyacetic acid derivatives market to reach $2.3 billion by 2027, with (2-Chloro-4-fluorophenoxy)acetic Acid capturing a 12% share. This growth is driven by Asia-Pacific demand, where crop yield optimization and pharmaceutical outsourcing are priorities. Regulatory compliance with REACH and FDA guidelines remains a key focus for manufacturers.

Frequently asked questions about CAS 399-41-7 include its solubility profile (soluble in ethanol, acetone; insoluble in water), storage conditions (2-8°C in amber glass), and handling precautions (use PPE under fume hood). These technical details are crucial for laboratories integrating this compound into high-throughput screening workflows.

Emerging applications in material science, particularly for liquid crystal formulations and polymeric additives, demonstrate the compound's cross-industry versatility. A 2023 ACS Materials Letters publication revealed its utility in enhancing thermal stability of biodegradable plastics, aligning with circular economy initiatives.

For researchers sourcing (2-Chloro-4-fluorophenoxy)acetic Acid, verifying supplier certifications (ISO 9001, GMP) and analytical documentation (CoA, MSDS) is essential. The compound's price fluctuates between $120-$180 per gram depending on purity (98-99.5%), with bulk discounts available for contract manufacturing agreements.

Ongoing studies investigate structure-activity relationships of modified phenoxyacetic acid derivatives, with 399-41-7 serving as a benchmark. Collaborative projects between academia and industry aim to develop next-generation compounds with improved bioavailability and environmental persistence profiles.

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• 331-40-8((3-Chloro-4-fluorophenoxy)acetic Acid)
• 614-61-9(2-(2-chlorophenoxy)acetic acid)
• 30364-07-9(Acetic acid,2-(2,5-dichloro-4-methoxyphenoxy)-)
• 181305-71-5(2-Chloro-4-fluorophenetole)
• 2639-78-3(Acetic acid,2-(2,5-dichloro-4-hydroxyphenoxy)-)
• 1979-24-4(Acetic acid,2-(2-chloro-4,6-difluorophenoxy)-)
• 1892-92-8(2-(2-Chloro-4-fluorophenoxy)propanoic acid)
• 582-54-7((2,5-Dichlorophenoxy)acetic Acid)
• 84794-72-9(2,2'-(2-Chloro-1,4-phenylene)bis(oxy)diacetic acid)