• 1. Design, synthesis, biological evaluation and docking studies of sulfonyl isatin derivatives as monoamine oxidase and caspase-3 inhibitors
  Mohsen Tavari,Sarel F. Malan,Jacques Joubert Med. Chem. Commun. 2016 7 1628

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylmethylamines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Comprehensive Overview of (2-Fluorobenzyl)methylamine (CAS No. 399-30-4): Properties, Applications, and Industry Insights

(2-Fluorobenzyl)methylamine (CAS No. 399-30-4) is a fluorinated organic compound with a molecular formula of C₈H₁₀FN. This versatile chemical intermediate has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural properties. The presence of a fluorine atom at the ortho position of the benzyl group enhances its electronic characteristics, making it valuable for designing bioactive molecules. Researchers often search for "2-Fluorobenzylmethylamine synthesis" or "399-30-4 applications," reflecting growing interest in its synthetic pathways.

In recent years, the demand for fluorinated compounds like (2-Fluorobenzyl)methylamine has surged, driven by trends in drug discovery and material science. The compound's ability to modulate lipophilicity and metabolic stability aligns with modern "medicinal chemistry optimization" strategies. Analytical techniques such as HPLC and NMR spectroscopy are commonly employed to verify its purity, a frequent topic in "CAS 399-30-4 characterization" queries. Its shelf stability under inert conditions makes it suitable for long-term storage in research laboratories.

The compound's role in heterocyclic synthesis is another area of industrial relevance. Patent databases reveal its use as a building block for fluorinated scaffolds, particularly in developing kinase inhibitors and GPCR-targeting molecules. Environmental considerations have also shaped discussions around "green chemistry approaches" for producing such intermediates, with microwave-assisted synthesis emerging as an energy-efficient alternative. Regulatory-compliant handling protocols ensure safe utilization across global research facilities.

Market analyses indicate rising procurement inquiries for 399-30-4 suppliers, especially from contract research organizations (CROs). Technical specifications typically emphasize ≥98% purity levels, with specialized packaging options for oxygen-sensitive batches. The compound's structure-activity relationship (SAR) contributions continue to inspire innovations in bioisostere design, addressing contemporary challenges in drug bioavailability enhancement.

Emerging applications in PET radiotracer development leverage the fluorine moiety for molecular imaging purposes. This interdisciplinary potential explains frequent searches for "2-fluorobenzylamine derivatives" across scientific databases. Quality control protocols involving GC-MS analysis and residual solvent testing meet stringent industry standards, while advanced crystallization techniques optimize its physical form for formulation studies.

Academic publications highlight its utility in asymmetric catalysis and chiral auxiliary applications, particularly in constructing stereogenic centers. The compound's logP value and pKa data are frequently referenced in QSAR modeling studies, addressing persistent questions about "fluorine effects in drug design." Continuous process improvements have reduced production costs, making scale-up synthesis economically viable for commercial projects.

Future research directions may explore its potential in bioconjugation chemistry and proteolysis-targeting chimera (PROTAC) development. The compound's compatibility with click chemistry reactions opens possibilities for combinatorial library generation. As sustainable chemistry gains prominence, catalytic fluorination methods for preparing such intermediates are becoming key investigation areas, reflecting evolving industry priorities.

• 69875-87-2(benzyl(2-fluorophenyl)methylamine)
• 392691-70-2((2,5-difluorophenyl)methyl(methyl)amine)
• 64567-25-5(ethyl[(2-fluorophenyl)methyl]amine)
• 381236-52-8((4-fluoro-3-methylphenyl)methyl(methyl)amine)
• 500221-67-0(Benzenemethanamine, 2,4-difluoro-N-(phenylmethyl)-)
• 696589-32-9(1-(2,4-Difluorophenyl)-N-methylmethanamine)
• 2341-21-1(1-(2-Fluorophenyl)-N,N-dimethylmethanamine)
• 392691-62-2(1-(2,6-Difluorophenyl)-N-methylmethanamine)
• 1020997-18-5(N-(3-fluorobenzyl)-1-(2-fluorophenyl)methanamine)
• 401-35-4(N-Benzyl-1-(2-fluorophenyl)-N-methylmethanamine)