• 1. Template synthesis of copper(II)lead(II) complexes of new binucleating macrocycles with dissimilar co-ordination sites
  Makoto Tadokoro,Hiroshi Sakiyama,Naohide Matsumoto,Masahito Kodera,Hisashi ōkawa,Sigeo Kida J. Chem. Soc. Dalton Trans. 1992 313

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

Comprehensive Overview of 2-(5-Bromopyridin-3-yl)acetonitrile (CAS No. 39891-08-2)

2-(5-Bromopyridin-3-yl)acetonitrile (CAS No. 39891-08-2) is a versatile organic compound widely used in pharmaceutical and agrochemical research. This brominated pyridine derivative is particularly valued for its role as a key intermediate in the synthesis of complex molecules. Its unique structure, featuring a cyanoethyl group attached to a 5-bromopyridine ring, makes it a valuable building block in medicinal chemistry and material science.

In recent years, the demand for 2-(5-bromopyridin-3-yl)acetonitrile has surged due to its applications in developing small-molecule inhibitors and biologically active compounds. Researchers are particularly interested in its potential for creating targeted therapies, aligning with the growing trend of precision medicine. The compound's reactivity and selective functionalization capabilities have also made it a subject of interest in catalysis studies and green chemistry initiatives.

The synthesis of 2-(5-bromopyridin-3-yl)acetonitrile typically involves palladium-catalyzed cross-coupling reactions, a method frequently discussed in organic synthesis forums and research publications. Its purification and characterization are critical steps, often analyzed using HPLC, NMR spectroscopy, and mass spectrometry. These techniques ensure the compound meets the high purity standards required for drug discovery applications.

From an industrial perspective, 2-(5-bromopyridin-3-yl)acetonitrile is gaining attention for its role in developing advanced materials, including organic electronics and photoactive compounds. Its electron-withdrawing properties and structural adaptability make it suitable for designing light-emitting diodes (OLEDs) and sensor technologies. This aligns with the increasing focus on sustainable technologies and energy-efficient solutions in the chemical industry.

Safety and handling of 2-(5-bromopyridin-3-yl)acetonitrile follow standard laboratory protocols, with emphasis on proper ventilation and personal protective equipment (PPE). While not classified as hazardous under normal conditions, its storage recommendations include keeping it in a cool, dry place away from strong oxidizers. These precautions are frequently highlighted in chemical safety databases and material safety data sheets (MSDS).

The future prospects of 2-(5-bromopyridin-3-yl)acetonitrile are closely tied to innovations in heterocyclic chemistry and drug design. As the pharmaceutical industry explores more bromine-containing scaffolds for kinase inhibitors and antiviral agents, this compound's relevance continues to grow. Its compatibility with high-throughput screening methods further enhances its utility in modern drug development pipelines.

For researchers seeking custom synthesis or bulk quantities of 2-(5-bromopyridin-3-yl)acetonitrile, several specialty chemical suppliers offer this compound with varying purity grades. The analytical certificates provided with these products are essential for ensuring reproducible results in experimental work. This aspect is particularly important for laboratories focusing on FDA submissions or GMP-compliant production.

• 1272357-22-8(1-(5-bromopyridin-3-yl)cyclopropane-1-carbonitrile)
• 142337-95-9(3-Bromo-5-ethylpyridine)
• 1209459-74-4(3-Bromo-5-isopropylpyridine)
• 1209458-34-3(3-Bromo-5-tert-butylpyridine)
• 1241752-24-8(3-Bromo-5-butylpyridine)
• 1195178-79-0(1-(5-Bromopyridin-3-yl)cyclopentanecarbonitrile)
• 1257432-08-8(2-(5-Bromopyridin-3-yl)-2-methylpropanenitrile)
• 1434127-13-5(3-Bromo-5-isobutylpyridine)
• 1807120-56-4(3-Bromo-4-methylpyridine-5-acetonitrile)
• 301220-81-5(3-Benzyl-5-bromopyridine)