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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives

Comprehensive Overview of 1-(Pyridine-2-carbonyl)piperazine (CAS No. 39639-98-0): Properties, Applications, and Industry Insights

1-(Pyridine-2-carbonyl)piperazine (CAS No. 39639-98-0) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural features and versatile reactivity. This heterocyclic molecule combines a pyridine ring with a piperazine moiety through a carbonyl linkage, making it a valuable intermediate in drug discovery and material science. Its molecular formula, C₁₀H₁₁N₃O, and molecular weight of 189.22 g/mol underscore its potential for precise applications in targeted synthesis.

In recent years, the demand for piperazine derivatives like 1-(Pyridine-2-carbonyl)piperazine has surged, driven by their role in developing central nervous system (CNS) therapeutics and antimicrobial agents. Researchers frequently explore its utility in modulating neurotransmitter receptors, particularly in the context of neurological disorders such as Parkinson’s disease and depression. The compound’s hydrogen-bonding capacity and lipophilic balance further enhance its pharmacokinetic profile, a topic widely searched in AI-driven drug design platforms.

The synthesis of CAS No. 39639-98-0 typically involves the acylation of piperazine with pyridine-2-carboxylic acid derivatives, a process optimized for high yield and purity. Analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry are critical for quality control, aligning with industry standards for pharmaceutical intermediates. These methodologies are frequently queried in academic and industrial forums, reflecting their relevance to green chemistry and sustainable synthesis trends.

Beyond pharmaceuticals, 1-(Pyridine-2-carbonyl)piperazine finds niche applications in agrochemicals and coordination chemistry. Its ability to act as a ligand for transition metals has spurred interest in catalysis and material science, particularly in the development of metal-organic frameworks (MOFs). This intersection of disciplines resonates with current searches on multi-functional chemicals and cross-industry innovations.

Regulatory and safety profiles of CAS No. 39639-98-0 adhere to global guidelines, with documented studies on its toxicological thresholds and environmental impact. Such data is crucial for compliance with REACH and FDA frameworks, topics highly prioritized by manufacturers and exporters. The compound’s stability under standard storage conditions (e.g., inert atmospheres, low humidity) further supports its commercial viability.

In conclusion, 1-(Pyridine-2-carbonyl)piperazine exemplifies the convergence of medicinal chemistry and industrial applications. Its adaptability to high-throughput screening and computational modeling positions it at the forefront of modern research, addressing queries on structure-activity relationships (SAR) and fragment-based drug discovery. As innovation accelerates, this compound is poised to remain a focal point in scientific and commercial discourse.

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