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  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 2. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 3. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
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• 4. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
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• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Introduction to 4-Methoxyphenylacetic Anhydride (CAS No. 3951-10-8)

4-Methoxyphenylacetic Anhydride, with the chemical formula C₉H₈O₃ and CAS number 3951-10-8, is a versatile intermediate in organic synthesis and pharmaceutical chemistry. This compound, also known as methyl 4-methoxybenzoate anhydride, is widely recognized for its utility in the synthesis of various bioactive molecules, including pharmaceuticals and agrochemicals. Its unique structural properties make it a valuable tool in the development of novel compounds with potential therapeutic applications.

The structure of 4-Methoxyphenylacetic Anhydride features a phenyl ring substituted with a methoxy group at the para position and an acetic anhydride moiety. This configuration allows for facile functionalization at multiple sites, making it a preferred building block in medicinal chemistry. The compound's stability under various reaction conditions further enhances its appeal as an intermediate in synthetic pathways.

In recent years, there has been growing interest in the applications of 4-Methoxyphenylacetic Anhydride in the development of innovative drug candidates. Its role as a precursor in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents has been extensively studied. Researchers have leveraged its reactivity to introduce diverse functional groups, enabling the creation of structurally diverse libraries for drug discovery.

One of the most significant contributions of 4-Methoxyphenylacetic Anhydride is its application in the synthesis of pharmaceutical intermediates. For instance, it has been utilized in the preparation of compounds targeting neurological disorders, where its structural motif contributes to enhanced binding affinity and improved pharmacokinetic profiles. The compound's ability to undergo selective reactions with nucleophiles has made it indispensable in constructing complex molecular architectures.

The synthetic utility of 4-Methoxyphenylacetic Anhydride extends beyond pharmaceuticals into agrochemical research. Its derivatives have been explored as potential herbicides and fungicides, demonstrating efficacy against various plant pathogens. The methoxy group at the phenyl ring enhances lipophilicity, improving membrane permeability and bioavailability, which are critical factors for agrochemical performance.

Recent advancements in green chemistry have also highlighted the importance of 4-Methoxyphenylacetic Anhydride as a sustainable intermediate. Researchers have developed catalytic methods to minimize waste and improve yields during its synthesis, aligning with global efforts to reduce environmental impact. These innovations underscore the compound's adaptability to evolving chemical methodologies.

The pharmacological potential of derivatives derived from 4-Methoxyphenylacetic Anhydride continues to be a subject of intense investigation. Studies have shown that modifications at the acetic anhydride moiety can significantly alter biological activity, leading to the discovery of novel therapeutic agents. For example, analogs with enhanced metabolic stability have been identified as promising candidates for treating chronic inflammatory diseases.

In conclusion, 4-Methoxyphenylacetic Anhydride (CAS No. 3951-10-8) represents a cornerstone in modern synthetic chemistry and drug development. Its versatility as an intermediate has enabled breakthroughs across multiple disciplines, from pharmaceuticals to agrochemicals. As research progresses, continued exploration of its derivatives promises to yield further innovations with profound implications for human health and agricultural productivity.

• 14062-18-1(Ethyl (4-Methoxyphenyl)acetate)
• 40784-88-1(Ethyl 4-ethoxyphenylacetate)
• 23786-14-3(Methyl 4-methoxyphenylacetate)
• 35553-92-5(Ethyl 3-methoxyphenylacetate)
• 14062-26-1(Ethyl 2-(4-phenoxyphenyl)acetate)
• 22532-57-6(Benzeneethanol,4-methoxy-, 1-propanoate)
• 6836-21-1(7-Methoxy-1-naphthaleneacetic acid ethylester)
• 4503-90-6(Benzeneacetic acid,4-methoxy-3-methyl-, ethyl ester)
• 64450-65-3(Benzeneacetic acid,4-methoxy-, 1-methylethyl ester)
• 89723-32-0(Benzeneacetic acid, 4-(acetyloxy)-, ethyl ester)