Cas no 395-23-3 (4-(Trifluoromethyl)benzhydrol)

4-(Trifluoromethyl)benzhydrol is a fluorinated aromatic alcohol with the molecular formula C??H??F?O. This compound features a benzhydrol core substituted with a trifluoromethyl group at the para position, enhancing its electron-withdrawing properties and chemical stability. The presence of the trifluoromethyl group improves lipophilicity, making it valuable in pharmaceutical and agrochemical synthesis as an intermediate. Its structural characteristics also lend utility in materials science, particularly in the development of specialty polymers and liquid crystals. The compound exhibits high purity and reactivity, facilitating precise modifications in organic synthesis. Handling should adhere to standard safety protocols for fluorinated aromatic compounds.

4-(Trifluoromethyl)benzhydrol structure

Product Name:4-(Trifluoromethyl)benzhydrol

CAS No:395-23-3

MF:C₁₄H₁₁F₃O

MW:252.231754541397

MDL:MFCD00014399

CID:82256

PubChem ID:258897

Update Time:2025-06-08

4-(Trifluoromethyl)benzhydrol Chemical and Physical Properties

Names and Identifiers

- Phenyl(4-(trifluoromethyl)phenyl)methanol
- Phenyl 4-(trifluoromethyl)phenyl carbinol~4-(Trifluoromethyl)diphenylmethanol
- 4-(Trifluoromethyl)benzhydrol
- phenyl-[4-(trifluoromethyl)phenyl]methanol
- AC-20897
- 5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLICACID1,1-DIMETHYLETHYLESTER
- AB-131/40897211
- NCIOpen2_005428
- AKOS004908861
- phenyl[4-(trifluoromethyl)phenyl]methanol
- MFCD00014399
- (4-trifluoromethylphenyl)(phenyl)methanol
- 4-Trifluoromethylbenzhydrol
- Benzhydrol, 4-trifluoromethyl-,
- NSC-88345
- CS-0156536
- SCHEMBL477694
- (4-(trifluoromethyl)phenyl)(phenyl)methanol
- D82074
- phenyl-(4-trifluoromethyl-phenyl)-methanol
- A824600
- DTXSID50293288
- 395-23-3
- CHEMBL611616
- AS-65252
- FT-0616914
- NSC88345
- Phenyl[4-(trifluoromethyl)phenyl]methanol, 4-[Hydroxy(phenyl)methyl]benzotrifluoride, Phenyl 4-(trifluoromethyl)phenyl carbinol
- DB-049427
- MDL： MFCD00014399
- Inchi： 1S/C14H11F3O/c15-14(16,17)12-8-6-11(7-9-12)13(18)10-4-2-1-3-5-10/h1-9,13,18H
- InChI Key： LIZDGCXCDJOWBS-UHFFFAOYSA-N
- SMILES： FC(C1C=CC(=CC=1)C(C1C=CC=CC=1)O)(F)F
- BRN： 2127184

Computed Properties

Exact Mass: 252.07600
Monoisotopic Mass: 252.076
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Heavy Atom Count: 18
Rotatable Bond Count: 3
Complexity: 250
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: nothing
Topological Polar Surface Area: 20.2A^2

Experimental Properties

Color/Form: Not available
Density: 122
Melting Point: 59 °C
Boiling Point: 122 °C
Flash Point: 122-124°C/0.4mm
Refractive Index: 1.531
PSA: 20.23000
LogP: 3.78710
Solubility: Not available

4-(Trifluoromethyl)benzhydrol Security Information

Hazard Statement： Flammable
Hazardous Material transportation number：1224
Hazard Category Code： 36/37/38
Safety Instruction： S26-S36/37/39
Hazardous Material Identification：
HazardClass：FLAMMABLE
Risk Phrases：R36/37/38
Safety Term：S26;S36

4-(Trifluoromethyl)benzhydrol Customs Data

HS CODE：2906299090
Customs Data：

China Customs Code:
2906299090

Overview:

2906299090 Other aromatic alcohols. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

Declaration elements:

Product Name, component content, use to

Summary:

2906299090 other aromatic alcohols.Supervision conditions:None.VAT:17.0%.Tax rebate rate:9.0%.MFN tariff:5.5%.General tariff:30.0%

4-(Trifluoromethyl)benzhydrol Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Fluorochem	007592-1g	4-(Trifluoromethyl)benzhydrol	395-23-3	97%	1g	￡24.00	2022-02-28
Fluorochem	007592-5g	4-(Trifluoromethyl)benzhydrol	395-23-3	97%	5g	￡94.00	2022-02-28
Alichem	A019110312-5g	Phenyl(4-(trifluoromethyl)phenyl)methanol	395-23-3	95%	5g	$557.44	2023-09-02
Alichem	A019110312-10g	Phenyl(4-(trifluoromethyl)phenyl)methanol	395-23-3	95%	10g	$844.87	2023-09-02
Alichem	A019110312-25g	Phenyl(4-(trifluoromethyl)phenyl)methanol	395-23-3	95%	25g	$1393.60	2023-09-02
SHANG HAI XIAN DING Biotechnology Co., Ltd.	005460-1g	4-(Trifluoromethyl)benzhydrol	395-23-3	97%	1g	306CNY	2021-05-07
SHANG HAI XIAN DING Biotechnology Co., Ltd.	B-CF069-5g	4-(Trifluoromethyl)benzhydrol	395-23-3	97%	5g	336.0CNY	2021-07-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	B-CF069-200mg	4-(Trifluoromethyl)benzhydrol	395-23-3	97%	200mg	55.0CNY	2021-07-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	B-CF069-1g	4-(Trifluoromethyl)benzhydrol	395-23-3	97%	1g	104.0CNY	2021-07-10
Apollo Scientific	PC7514-5g	4-(Trifluoromethyl)benzhydrol	395-23-3	97%	5g	￡54.00	2024-05-25

4-(Trifluoromethyl)benzhydrol Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:395-23-3)4-(Trifluoromethyl)benzhydrol

Order Number:A824600

Stock Status:in Stock

Quantity:100g

Purity:99%

Pricing Information Last Updated:Monday, 2 September 2024 16:10

Price ($):330.0

Email:[email protected]

Product Official Link

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Related Categories

Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Diphenylmethanes

Additional information on 4-(Trifluoromethyl)benzhydrol

Professional Introduction to 4-(Trifluoromethyl)benzhydrol (CAS No. 395-23-3)

4-(Trifluoromethyl)benzhydrol, with the chemical formula C₈H₇F₃O, is a fluorinated aromatic compound that has garnered significant attention in the field of pharmaceutical chemistry and organic synthesis. This compound, identified by its CAS number CAS No. 395-23-3, exhibits unique structural and electronic properties due to the presence of a trifluoromethyl group, which imparts enhanced stability and reactivity compared to its non-fluorinated counterparts.

The trifluoromethyl group is a key feature in medicinal chemistry, as it can influence the metabolic pathways and binding affinity of molecules. In recent years, there has been a surge in research focused on fluorinated compounds due to their potential in drug development. Specifically, 4-(Trifluoromethyl)benzhydrol has been explored for its applications in synthesizing novel pharmaceutical agents that target various biological pathways.

One of the most compelling aspects of 4-(Trifluoromethyl)benzhydrol is its versatility in chemical transformations. The compound serves as a valuable intermediate in the synthesis of more complex molecules, including those with potential therapeutic applications. For instance, researchers have utilized this compound in the development of kinase inhibitors, which are critical in treating cancers and inflammatory diseases. The electron-withdrawing nature of the trifluoromethyl group enhances the reactivity of the aromatic ring, making it an ideal candidate for further functionalization.

In addition to its role in pharmaceutical synthesis, 4-(Trifluoromethyl)benzhydrol has been investigated for its properties as a ligand in coordination chemistry. The presence of both hydroxyl and aromatic functionalities allows for interactions with transition metals, which can be leveraged in catalytic processes. Recent studies have demonstrated its use in designing metal-organic frameworks (MOFs) and supramolecular assemblies, where the fluorinated group contributes to steric hindrance and electronic tuning.

The pharmacological potential of 4-(Trifluoromethyl)benzhydrol has also been explored through computational modeling and high-throughput screening. These approaches have identified several derivatives with improved pharmacokinetic profiles and reduced toxicity. The incorporation of the trifluoromethyl group has been shown to modulate drug-receptor interactions, leading to enhanced binding affinity and selectivity. This has opened new avenues for developing targeted therapies against resistant pathogens and chronic diseases.

In conclusion, 4-(Trifluoromethyl)benzhydrol (CAS No. 395-23-3) is a multifaceted compound with significant implications in pharmaceutical research and industrial applications. Its unique structural features and reactivity make it a valuable building block for synthesizing novel drugs and materials. As research continues to uncover new applications for fluorinated compounds, the importance of 4-(Trifluoromethyl)benzhydrol is likely to grow, further solidifying its role as a cornerstone in modern chemical biology.

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