Cas no 39236-46-9 (Imidazolidinyl urea)

Imidazolidinyl urea is a formaldehyde-releasing preservative commonly used in cosmetic and personal care formulations. It functions as an antimicrobial agent, effectively inhibiting the growth of bacteria, yeast, and molds in water-based products. This heterocyclic compound is valued for its broad-spectrum efficacy, stability across a wide pH range, and compatibility with various cosmetic ingredients. Its slow release of formaldehyde ensures prolonged preservative action while minimizing potential irritation. Imidazolidinyl urea is particularly suitable for rinse-off products and formulations requiring mild preservation. As a non-phenolic preservative, it offers an alternative for formulations where traditional parabens may be undesirable. Its effectiveness at low concentrations contributes to its widespread use in the industry.

Imidazolidinyl urea structure

Product Name:Imidazolidinyl urea

CAS No:39236-46-9

MF:C₁₁H₁₆N₈O₈

MW:388.29354095459

MDL:MFCD00221482

CID:54996

PubChem ID:38258

Update Time:2026-05-20

Imidazolidinyl urea Chemical and Physical Properties

Names and Identifiers

- 1,1'-Methylenebis(3-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea)
- 1,1-METHYLENEBIS[3-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
- IMIDAZOLIDINYL UREA
- n,n-methylenebis n'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
- N,N''-METHYLENEBIS[N'-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
- N,N''-METHYLENEBIS[N-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]
- germall115
- methanebis(n,n’-(5-ureido-2,4-diketotetrahydroimidazole)-n,n-dimethylol)
- n,n’’-methylenebis(n’-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-ure
- n,n’’-methylenebis[n’-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-ure
- Biopure 100
- Imidurea NF
- Sept 115
- Unicide U-13
- N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]
- N.N''-Methylenebis-{N'-(3-hydroxymethyl)-2,5-dioxo-4-imidazolenyl-urea}
- Urea, N,N-methylenebisN-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl-
- Imidurea
- 1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoylamino]methyl]urea
- C11H16N8O8
- N,N`-Methylenebis[N`-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl] urea
- 1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-diox
- N,N'-Methylenebis[N'-(3-hydroxymethyl-2,5-dioxo-4-imidazolidinyl)urea]
- N,N''-Methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-urea
- N,N'-Methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-urea
- N,N′′-Methylenebis[N′-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-urea
- 1,1'-Methylenebis[3-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea]
- N,N'-Methylenebis[N'-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl] urea
- Germall 115
- Imidazolinidyl urea
- Imidurea [NF]
- Methanebis(N,N'-(5-ureido-2,4-diketotetrahydroimidazole)-N,N-dimethylol)
- MLS002154142
- M629807ATL
- Imidurea (NF)
- N,N''-Methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
- AK106225
- SMR001233448
- 1,1'-Methylenebis(3-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
- N'
- 1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoylamin
- Methanebis(N,N'(5ureido2,4diketotetrahydroimidazole)N,Ndimethylol)
- N,N''Methylenebis(N'(1(hydroxymethyl)2,5dioxo4imidazolidinyl)urea)
- NCGC00179313-05
- MFCD00221482
- DTXCID0020151
- N,N''-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidin-yl)urea
- DB14075
- Prestwick0_001071
- IMIDUREA (MART.)
- IMIDAZOLIDINYL UREA [INCI]
- CAS-39236-46-9
- Urea, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-
- IMIDUREA [MART.]
- 1,1'-METHYLENEBIS(3-(3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL)UREA
- AB00514030
- AS-15260
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N
- Urea, N,N''methylenebis(N'(3(hydroxymethyl)2,5dioxo4imidazolidin yl)
- EN300-19627076
- 1-(2,5-diketo-3-methylol-imidazolidin-4-yl)-3-[[(2,5-diketo-3-methylol-imidazolidin-4-yl)carbamoylamino]methyl]urea
- EC 254-372-6
- Prestwick1_001071
- 1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]c
- D04513
- Q2737856
- N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
- EINECS 254-372-6
- BSPBio_001082
- N,N''-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidin- yl)urea
- 3-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1-[({[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoyl}amino)methyl]urea
- SPBio_002991
- 3-[4-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1-[({[4-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoyl}amino)methyl]urea
- s10971
- HMS1571G04
- SR-01000841816-2
- Tox21_302325
- Tox21_112112
- N',N'''-methanediylbis{1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea}
- HMS3715G04
- Urea, N,N''methylenebis(N'(3(hydroxymethyl)2,5dioxo4imidazolidinyl)
- CHEBI:51805
- Prestwick3_001071
- NCGC00179313-01
- N,N''Methylenebis(N'(3(hydroxymethyl)2,5dioxoimidazolidin4yl)urea)
- 3-(4-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-1-((((4-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)carbamoyl)amino)methyl)urea
- N,N''Methylenebis(N'(3(hydroxymethyl)2,5dioxo4imidazolidin yl)urea
- NCGC00164388-01
- BPBio1_001192
- N,N'-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
- BDBM66981
- HY-B1158
- Urea, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidin-yl)-
- Urea, N,N''methylenebis(N'(1(hydroxymethyl)2,5dioxo4imidazolidinyl)
- CHEMBL65433
- cid_38258
- IMIDUREA [II]
- 1,1'Methylenebis(3(3(hydroxymethyl)2,5dioxo4imidazolidinyl)urea)
- IMIDUREA [MI]
- 1-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-3-[[[[[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]amino]-oxomethyl]amino]methyl]urea
- Imidurea, Pharmaceutical Secondary Standard; Certified Reference Material
- AKOS015895558
- SR-01000841816
- imidazolidinylurea
- Imidurea, United States Pharmacopeia (USP) Reference Standard
- N',N'''-methanediylbis(1-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea)
- IMIDUREA [VANDF]
- N,N''-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea)
- IMIDUREA (USP-RS)
- DA-74451
- CCG-221071
- CS-4609
- HMS3369E04
- IMIDUREA (II)
- SCHEMBL34461
- IMIDAZOLIDINYL UREA [VANDF]
- 39236-46-9
- NS00002748
- IMIDUREA [USP-RS]
- HMS2230O16
- Urea, N,N''-methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-
- N,N'-Methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea]
- UNII-M629807ATL
- HMS2098G04
- DTXSID2040151
- BRD-A65444648-001-11-4
- 1-[3-(hydroxymethyl)-2,5-dioxo-imidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxo-imidazolidin-4-yl]carbamoylamino]methyl]urea
- NCGC00179313-03
- Urea, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidin- yl)-
- NCGC00255574-01
- s5212
- I0665
- Prestwick2_001071
- 1-[3-(hydroxymethyl)-2,5-bis(oxidanylidene)imidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-bis(oxidanylidene)imidazolidin-4-yl]carbamoylamino]methyl]urea
- N,N'Methylenebis(N'(3(hydroxymethyl)2,5dioxo4imidazolidinyl)urea)
- Imidazolidinyl urea
- MDL： MFCD00221482
- Inchi： 1S/C11H16N8O8/c20-2-18-4(6(22)16-10(18)26)14-8(24)12-1-13-9(25)15-5-7(23)17-11(27)19(5)3-21/h4-5,20-21H,1-3H2,(H2,12,14,24)(H2,13,15,25)(H,16,22,26)(H,17,23,27)
- InChI Key： ZCTXEAQXZGPWFG-UHFFFAOYSA-N
- SMILES： O=C1C(NC(NCNC(NC2C(NC(N2CO)=O)=O)=O)=O)N(CO)C(N1)=O

Computed Properties

Exact Mass: 388.10900
Monoisotopic Mass: 388.109
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 8
Hydrogen Bond Acceptor Count: 8
Heavy Atom Count: 27
Rotatable Bond Count: 6
Complexity: 627
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 2
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: -3.4
Tautomer Count: 120
Surface Charge: 0
Topological Polar Surface Area: 222
Molecular Weight: 388.29

Experimental Properties

Color/Form: White fluid powder
Density: 1.4245 (rough estimate)
Melting Point: 225-235°C
Boiling Point: 514.04°C (rough estimate)
Flash Point: No data available
Refractive Index: 1.6910 (estimate)
Solubility: 生物體外In Vitro:DMSO溶解度≥ 4 mg/mL(10.30 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
Water Partition Coefficient: dissolution
Stability/Shelf Life: Stable.
PSA: 221.54000
LogP: -2.70530
Solubility: Hydrolyzable
Sensitiveness: Sensitive to heat and air
Merck: 4916

Imidazolidinyl urea Security Information

Symbol:
Prompt：warning
Signal Word：Warning
Hazard Statement： H317
Warning Statement： P280
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：2
Hazard Category Code： 36
Safety Instruction： S26-S36
RTECS：YT7365000
Hazardous Material Identification：
TSCA：Yes
Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Risk Phrases：R36

Imidazolidinyl urea Customs Data

Customs Data：

China Customs Code:
2933990090

Overview:

2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

Declaration elements:

Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

Summary:

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Imidazolidinyl urea Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	I133416-25g	Imidazolidinyl urea	39236-46-9	98%	25g	￥46.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	I133416-1kg	Imidazolidinyl urea	39236-46-9	98%	1kg	￥824.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	I133416-500g	Imidazolidinyl urea	39236-46-9	98%	500g	￥504.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	I133416-100g	Imidazolidinyl urea	39236-46-9	98%	100g	￥165.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	I133416-2.5kg	Imidazolidinyl urea	39236-46-9	98%	2.5kg	￥1648.90	2023-09-02
S e l l e c k ZHONG GUO	S5212-25mg	Imidazolidinyl Urea	39236-46-9	98%	25mg	￥795.19	2023-09-15
SHANG HAI YI EN HUA XUE JI SHU Co., Ltd.	R017197-100g	Imidazolidinyl urea	39236-46-9	98%	100g	￥143	2024-05-23
ChemScence	CS-4609-500mg	Imidazolidinyl urea	39236-46-9	95.63%	500mg	$50.0	2022-04-27
ChemScence	CS-4609-1g	Imidazolidinyl urea	39236-46-9	95.63%	1g	$60.0	2022-04-27
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.	I824370-5kg	Imidurea	39236-46-9	98%	5kg	￥2,990.00	2022-01-11

Imidazolidinyl urea Suppliers

Suzhou Senfeida Chemical Co., Ltd

Gold Member

Audited Supplier

(CAS:39236-46-9)Imidazolidinyl urea

Order Number:sfd7993

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:34

Price ($):discuss personally

Email:[email protected]

Product Official Link

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:39236-46-9)N,N-Methylenebis N'-1-(hydroxyMethyl)-2,5-dioxo-4-iMidazolidinyl urea

Order Number:LE18795;LE25922238

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:20

Price ($):discuss personally

Email:[email protected]

Imidazolidinyl urea Spectrogram

1H NMR

300 MHz

DMSO

13C NMR

Imidazolidinyl urea Related Literature

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Qianyun Zhong,Xingxing Chen,Yuxuan Yang,Chenhui Cui,Li Ma,Zhen Li,Qiang Zhang,Xiaoming Chen,Yilong Cheng,Yanfeng Zhang Mater. Chem. Front. 2021 5 5371
2. Construction of supramolecular hydrogels using imidazolidinyl urea as hydrogen bonding reinforced factor

Jing Yu,Xingxing Chen,Yuxuan Yang,Xiaodan Zhao,Xiaojing Chen,Tianhong Jing,Yang Zhou,Jiangping Xu,Yanfeng Zhang,Yilong Cheng J. Mater. Chem. B 2020 8 3058
3. Supported Pt–Cu bimetallic catalysts: preparation and synergic effects in their catalytic oxidative degradation of aniline

Qiuyue Ding,Wumin Zhang,Yuanyuan Zhu,Lu Wang,Xinyuan Feng,Yanyan Xi,Xufeng Lin RSC Adv. 2021 11 34355
4. Detection of formaldehyde in food samples by enhanced chemiluminescence

Uchangi Satyaprasad Akshath,L. Sagaya Selvakumar,Munna Singh Thakur Anal. Methods 2012 4 699
5. A review: progress in preventing tissue adhesions from a biomaterial perspective

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Related Categories

Additional information on Imidazolidinyl urea

Imidazolidinyl urea (CAS No. 39236-46-9): A Comprehensive Overview in Modern Chemical and Pharmaceutical Research

Imidazolidinyl urea, a compound with the chemical identifier CAS No. 39236-46-9, has garnered significant attention in the realm of chemical and pharmaceutical research due to its versatile applications and unique structural properties. This heterocyclic compound, featuring a six-membered ring with nitrogen atoms, has been extensively studied for its potential in various biochemical processes and drug development. The imidazolidinyl urea structure not only provides a stable framework for further functionalization but also exhibits promising interactions with biological targets, making it a valuable candidate for innovative therapeutic strategies.

The compound's significance is further underscored by its role in synthesizing advanced materials and pharmaceutical intermediates. Recent studies have highlighted the imidazolidinyl urea's ability to act as a precursor in the development of novel polymers and coatings that exhibit enhanced durability and biocompatibility. These properties make it particularly relevant in the manufacturing of medical devices and implants, where long-term stability and interaction with biological systems are critical.

In the pharmaceutical domain, the CAS No. 39236-46-9 compound has been explored for its potential antimicrobial and anti-inflammatory properties. Research indicates that derivatives of imidazolidinyl urea can interfere with microbial cell wall synthesis, offering a novel approach to combating resistant bacterial strains. Additionally, its structural motif has been integrated into drug molecules designed to modulate inflammatory pathways, providing new avenues for treating chronic inflammatory conditions.

The synthesis of imidazolidinyl urea involves intricate organic reactions that highlight its versatility as a building block. Advanced synthetic methodologies have enabled the introduction of various substituents into the core structure, allowing for fine-tuning of its pharmacological properties. Techniques such as transition-metal-catalyzed cross-coupling reactions and enzymatic modifications have been employed to achieve high yields and purity, ensuring that researchers can explore its full potential without compromising on quality.

One of the most compelling aspects of imidazolidinyl urea is its adaptability in drug design. By leveraging its ability to form hydrogen bonds and coordinate with metal ions, this compound has been incorporated into targeted drug delivery systems. These systems aim to enhance therapeutic efficacy while minimizing side effects by delivering drugs directly to affected tissues or cells. The incorporation of imidazolidinyl urea into nanocarriers has shown particular promise in improving bioavailability and reducing systemic toxicity.

The environmental impact of using imidazolidinyl urea has also been a point of interest. Studies have demonstrated that certain derivatives can degrade under specific conditions, reducing their environmental footprint. This biodegradability is crucial for ensuring that applications involving this compound do not contribute to long-term pollution issues. Furthermore, efforts are underway to develop more sustainable synthetic routes that minimize waste and energy consumption, aligning with global efforts towards green chemistry principles.

The future prospects for imidazolidinyl urea are vast, with ongoing research uncovering new applications in areas such as materials science, agriculture, and renewable energy. Its unique chemical properties make it an ideal candidate for developing next-generation materials with enhanced functionalities. In agriculture, derivatives of this compound are being explored as potential plant growth regulators and pest control agents, offering environmentally friendly alternatives to traditional agrochemicals.

In conclusion, imidazolidinyl urea (CAS No. 39236-46-9) represents a cornerstone in modern chemical research, bridging the gap between fundamental science and practical applications. Its versatility in drug development, material science, and environmental sustainability underscores its importance as a research chemical. As scientists continue to unravel its potential, we can expect even more innovative uses to emerge, further solidifying its role as a key player in advancing scientific knowledge and technological progress.

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