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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonyl compounds

Comprehensive Guide to Benzenesulfonylfluoride, 2-amino- (CAS No. 392-86-9): Properties, Applications, and Market Insights

Benzenesulfonylfluoride, 2-amino- (CAS No. 392-86-9) is a specialized organosulfur compound with significant relevance in modern chemical research and industrial applications. This aromatic sulfonyl fluoride derivative, characterized by its amino-functionalized benzene ring and sulfonyl fluoride group, has garnered attention for its unique reactivity profile and versatility in synthetic chemistry. The compound's molecular structure combines the electron-donating properties of the amino group with the electrophilic character of the sulfonyl fluoride moiety, making it particularly valuable for click chemistry applications and bioconjugation strategies.

Recent scientific literature highlights the growing importance of 2-amino-benzenesulfonylfluoride in proteomics research, where its selective reactivity with serine hydrolases enables advanced enzyme activity profiling. This application aligns with current trends in precision medicine and drug discovery, addressing frequent search queries about "targeted enzyme inhibitors" and "chemical probes for biological systems." The compound's ability to form stable covalent bonds with biological targets while maintaining excellent aqueous stability makes it particularly valuable for chemical biology studies.

The synthesis of Benzenesulfonylfluoride, 2-amino- typically involves the fluorination of 2-aminobenzenesulfonyl chloride or related precursors, with modern protocols emphasizing atom economy and green chemistry principles – topics frequently searched in connection with sustainable chemical production. Analytical characterization of this compound requires specialized techniques including 19F NMR spectroscopy and high-resolution mass spectrometry, reflecting the increasing sophistication demanded in chemical quality control protocols.

In material science applications, researchers have explored 2-aminobenzenesulfonyl fluoride derivatives as building blocks for functional polymers and surface modification agents. These applications respond to growing market demands for advanced materials with tailored surface properties, particularly in the biomedical device and microelectronics sectors. The compound's dual functionality enables the creation of multifunctional coatings that address common search terms like "anti-fouling surfaces" and "bioactive materials."

Market analysis indicates steady growth in demand for amino-substituted sulfonyl fluorides, driven by expanding applications in pharmaceutical intermediates and agrochemicals. Industry reports suggest particular interest in the compound's potential for creating covalent inhibitors, a hot topic in drug development circles. The global market for such specialized intermediates is projected to grow at a CAGR of 6-8% through 2028, with Asia-Pacific regions showing particularly strong demand growth.

From a safety perspective, Benzenesulfonylfluoride, 2-amino- requires standard laboratory precautions typical for reactive organofluorine compounds. Proper handling procedures emphasize the importance of personal protective equipment and adequate ventilation, addressing common workplace safety concerns. The compound's stability profile makes it suitable for standard chemical storage conditions, though moisture-sensitive handling is recommended to maintain optimal purity.

Emerging research directions for 2-amino-benzenesulfonylfluoride include its potential in covalent organic frameworks (COFs) and as a ligand anchor in catalytic systems. These applications align with trending searches about "advanced functional materials" and "heterogeneous catalysis." The compound's unique combination of nucleophilic (amino) and electrophilic (sulfonyl fluoride) centers offers intriguing possibilities for supramolecular chemistry applications.

Quality specifications for commercial Benzenesulfonylfluoride, 2-amino- typically require ≥98% purity by HPLC analysis, with particular attention to hydrolytic stability and colorimetric standards. These parameters reflect the compound's applications in sensitive bioconjugation chemistry, where purity requirements often exceed standard laboratory chemical grades. Analytical certificates for research-grade material typically include comprehensive spectroscopic data and batch-specific characterization.

Environmental considerations for 2-aminobenzenesulfonyl fluoride focus on its biodegradation pathways and aquatic toxicity profile, addressing increasing regulatory and sustainability concerns. Recent studies have investigated the compound's environmental fate using advanced mass spectrometry techniques, responding to industry needs for better green chemistry metrics and environmental impact assessments.

The future outlook for Benzenesulfonylfluoride, 2-amino- appears promising, with potential expansions into diagnostic reagent applications and materials science innovations. As research continues to uncover new applications for this versatile compound, its role in bridging small molecule chemistry and biological systems will likely grow in importance, positioning it as a valuable tool in both academic and industrial settings.

• 98-62-4(Sulfanilylfluoride)
• 445-16-9(2-amino-4-methylbenzene-1-sulfonyl fluoride)
• 3887-48-7(3-aminobenzene-1-sulfonyl fluoride hydrochloride)
• 98064-61-0(6-aminonaphthalene-2-sulfonyl fluoride)
• 133213-11-3(1,3,5-Benzenetrisulfonyl trifluoride, 2-amino-)
• 93496-73-2(Benzenesulfonyl fluoride, 2-amino-5-iodo-)
• 59651-55-7(Benzenesulfonyl fluoride, 2-isocyanato-)
• 88654-57-3(Benzenesulfonyl fluoride, 4-amino-, hydrochloride)
• 717-59-9(1,3-Benzenedisulfonyl difluoride, 5-amino-)
• 368-50-3(3-aminobenzene-1-sulfonyl fluoride)