• 1. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 2. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
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• 5. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

Introduction to 4-Methyl-1-piperidineethanol (CAS No. 39123-23-4)

4-Methyl-1-piperidineethanol, identified by its Chemical Abstracts Service (CAS) number 39123-23-4, is a significant compound in the realm of pharmaceutical chemistry and drug development. This piperidine derivative exhibits a unique structural framework that has garnered attention for its potential applications in medicinal chemistry, particularly in the synthesis of bioactive molecules. The compound features a piperidine ring substituted with a methyl group at the 4-position and an ethanol moiety at the 1-position, which together contribute to its distinct chemical and pharmacological properties.

The chemical structure of 4-Methyl-1-piperidineethanol makes it a versatile intermediate in organic synthesis. Its piperidine core is a common scaffold in many pharmacologically active agents, including antipsychotics, antihistamines, and anticonvulsants. The presence of the methyl group enhances the lipophilicity of the molecule, while the ethanol side chain introduces polarity, making it an attractive candidate for further functionalization. This balance of hydrophobic and hydrophilic characteristics is crucial for optimizing drug-like properties such as solubility, bioavailability, and metabolic stability.

In recent years, there has been growing interest in 4-Methyl-1-piperidineethanol due to its role in the development of novel therapeutic agents. One notable area of research involves its application in the synthesis of small-molecule inhibitors targeting neurological disorders. For instance, studies have demonstrated its utility in creating analogs of dopamine receptor modulators, which are essential for treating conditions such as Parkinson's disease and schizophrenia. The flexibility of the piperidine ring allows for structural modifications that can fine-tune receptor binding affinity and selectivity.

Another emerging field where 4-Methyl-1-piperidineethanol has shown promise is in anti-inflammatory drug discovery. Researchers have leveraged its scaffold to design molecules that interact with inflammatory pathways. Specifically, derivatives of this compound have been investigated for their ability to modulate cytokine production and inhibit enzymes involved in inflammation. Preliminary findings suggest that certain analogs exhibit significant anti-inflammatory activity without compromising safety profiles, making them promising candidates for further clinical development.

The pharmaceutical industry has also explored 4-Methyl-1-piperidineethanol as a building block for antibiotics and antiviral agents. Its structural motif is well-suited for mimicking natural products or designed scaffolds that can disrupt microbial cell wall synthesis or viral replication mechanisms. For example, modifications to the ethanol side chain have been explored to enhance binding interactions with bacterial enzymes or viral proteases. Such efforts align with the global need for novel antimicrobial therapies to combat rising resistance rates.

From a synthetic chemistry perspective, 4-Methyl-1-piperidineethanol offers several advantages as an intermediate. Its reactivity allows for facile introduction of various functional groups, enabling the creation of diverse molecular libraries for high-throughput screening. Advances in synthetic methodologies have further streamlined access to this compound, reducing production costs and improving scalability. These developments are particularly important for academic institutions and pharmaceutical companies seeking to expedite drug discovery pipelines.

The biological activity of 4-Methyl-1-piperidineethanol extends beyond traditional pharmacological targets. Recent studies have highlighted its potential in regenerative medicine and tissue engineering. Researchers have incorporated derivatives of this compound into biomaterials designed to promote cell proliferation and differentiation. The ability of these derivatives to interact with biological molecules suggests their utility in developing scaffolds that support tissue repair or regeneration.

In conclusion, 4-Methyl-1-piperidineethanol (CAS No. 39123-23-4) is a multifaceted compound with broad applications across pharmaceutical research and development. Its unique structural features make it a valuable intermediate for synthesizing bioactive molecules targeting various diseases. As research continues to uncover new therapeutic possibilities, the significance of this compound is likely to grow further, reinforcing its position as a cornerstone in modern medicinal chemistry.

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