• 1. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 4. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 5. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161

Introduction to 4-(4-Bromophenyl)-2-chlorothiazole (CAS No. 3884-33-1)

4-(4-Bromophenyl)-2-chlorothiazole, with the CAS number 3884-33-1, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique structural features, including a brominated phenyl group and a chlorothiazole moiety, which contribute to its potential applications in drug discovery and development.

The chemical structure of 4-(4-Bromophenyl)-2-chlorothiazole is represented by the formula C₉H₆BrClNS. The bromine and chlorine atoms, along with the thiazole ring, impart specific chemical properties that make this compound a valuable building block in synthetic chemistry. The thiazole ring, in particular, is known for its biological activity and has been widely studied for its potential in various therapeutic applications.

Recent advancements in the field of medicinal chemistry have highlighted the importance of 4-(4-Bromophenyl)-2-chlorothiazole as a key intermediate in the synthesis of novel pharmaceuticals. Researchers have explored its use in the development of drugs targeting various diseases, including cancer, neurodegenerative disorders, and infectious diseases. The brominated phenyl group provides a handle for further functionalization, allowing chemists to introduce additional functionalities that can enhance the pharmacological properties of the final product.

In the context of drug discovery, 4-(4-Bromophenyl)-2-chlorothiazole has been utilized as a scaffold for the design of small molecules with potent biological activities. For instance, studies have shown that derivatives of this compound exhibit significant anti-cancer properties by inhibiting key enzymes involved in tumor growth and metastasis. Additionally, its ability to cross the blood-brain barrier makes it an attractive candidate for developing treatments for neurological conditions.

The synthetic accessibility of 4-(4-Bromophenyl)-2-chlorothiazole has also contributed to its widespread use in academic and industrial laboratories. Various synthetic routes have been developed to produce this compound efficiently and cost-effectively. One common approach involves the reaction of 4-bromoaniline with 2-chloroacetyl chloride followed by cyclization with thiourea. This method yields high purity products suitable for further chemical transformations.

Beyond its role as an intermediate in drug synthesis, 4-(4-Bromophenyl)-2-chlorothiazole has also found applications in other areas of chemistry. For example, it can serve as a ligand in coordination chemistry, forming complexes with transition metals that exhibit interesting catalytic properties. These complexes have been used in catalytic reactions such as C-H activation and cross-coupling reactions, which are crucial for the synthesis of complex organic molecules.

The environmental and safety aspects of 4-(4-Bromophenyl)-2-chlorothiazole have also been studied to ensure its safe handling and disposal. While it is not classified as a hazardous material, proper precautions should be taken during its use to minimize any potential risks. Laboratory protocols recommend using personal protective equipment (PPE) such as gloves and goggles when handling this compound.

In conclusion, 4-(4-Bromophenyl)-2-chlorothiazole (CAS No. 3884-33-1) is a multifaceted compound with significant potential in medicinal chemistry and pharmaceutical research. Its unique structural features and synthetic accessibility make it an invaluable tool for scientists working on drug discovery and development. As research continues to advance, it is likely that new applications and derivatives of this compound will emerge, further expanding its impact on human health and well-being.

• 99797-29-2(2-chloro-4-4-(propan-2-yl)phenyl-1,3-thiazole)
• 2103-96-0(2-Chloro-4-(4-chlorophenyl)thiazole)
• 61323-78-2(Thiazole, 2-chloro-4-(4-ethylphenyl)-)
• 3884-32-0(2-chloro-4-(4-methylphenyl)-1,3-thiazole)
• 155294-66-9( )
• 786610-33-1( )
• 1826-20-6(4-(4-Bromophenyl)thiazole)
• 1826-23-9(2-Chloro-4-phenylthiazole)
• 99797-30-5(2-Chloro-4-(2,4-dimethylphenyl)-1,3-thiazole)
• 99983-82-1( )