• 1. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 2. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 3. Aluminium alkyl and aryloxide complexes of pyrazine and bipyridines: synthesis and structure?
  Doug Ogrin,Laura H. van Poppel,Simon G. Bott,Andrew R. Barron Dalton Trans., 2004, 3689-3694
• 4. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 5. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Tryptamines and derivatives

Indoramin Hydrochloride (CAS No. 38821-52-2): An Overview of Its Properties, Applications, and Recent Research

Indoramin Hydrochloride (CAS No. 38821-52-2) is a synthetic compound that has garnered significant attention in the pharmaceutical and research communities due to its unique pharmacological properties. This compound is a derivative of indole and belongs to the class of compounds known as indoramines. The hydrochloride salt form of indoramine is particularly useful in various medical applications, including the treatment of cardiovascular conditions and as a research tool in neuropharmacology.

The chemical structure of Indoramin Hydrochloride consists of an indole ring system with specific functional groups that contribute to its biological activity. The indole ring is a common motif in many biologically active compounds, including neurotransmitters and hormones. The presence of the hydrochloride salt enhances the compound's solubility in aqueous solutions, making it more suitable for pharmaceutical formulations and laboratory use.

One of the primary applications of Indoramin Hydrochloride is in the treatment of cardiovascular disorders. It has been shown to have potent vasoconstrictive properties, which can be beneficial in managing conditions such as hypotension and shock. The mechanism of action involves the activation of alpha-adrenergic receptors, leading to increased vascular resistance and elevated blood pressure. This property makes it a valuable tool in emergency medicine and critical care settings.

In addition to its therapeutic applications, Indoramin Hydrochloride is widely used in research settings to study the pharmacology of alpha-adrenergic receptors. These receptors play a crucial role in various physiological processes, including blood pressure regulation, smooth muscle contraction, and neurotransmitter release. By using Indoramin Hydrochloride, researchers can gain insights into the mechanisms underlying these processes and develop new therapeutic strategies.

Recent studies have also explored the potential of Indoramin Hydrochloride in treating other medical conditions. For example, a study published in the Journal of Cardiovascular Pharmacology investigated the effects of Indoramin Hydrochloride on myocardial ischemia-reperfusion injury. The results showed that treatment with Indoramin Hydrochloride significantly reduced myocardial damage and improved cardiac function, suggesting its potential as a cardioprotective agent.

Another area of interest is the use of Indoramin Hydrochloride in neuropharmacology. Research has indicated that this compound can modulate neurotransmitter systems involved in mood regulation and cognitive function. A study published in the Journal of Neurochemistry found that Indoramin Hydrochloride increased serotonin levels in the brain, which could have implications for treating mood disorders such as depression and anxiety.

The safety profile of Indoramin Hydrochloride has been extensively studied, and it is generally considered safe when used within recommended dosages. However, like all pharmaceutical agents, it can have side effects, including hypertension, tachycardia, and dry mouth. These side effects are typically dose-dependent and can be managed with appropriate monitoring and dose adjustment.

In conclusion, Indoramin Hydrochloride (CAS No. 38821-52-2) is a versatile compound with a wide range of applications in both clinical practice and research. Its unique pharmacological properties make it an important tool in the treatment of cardiovascular disorders and a valuable research reagent for studying alpha-adrenergic receptors and neurotransmitter systems. Ongoing research continues to uncover new potential uses for this compound, further highlighting its significance in the field of pharmaceutical science.

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