• 1. Sol–gel preparation of low oxygen content, high surface area silicon nitride and imidonitride materials
  Kripasindhu Sardar,Richard Bounds,Marina Carravetta,Geoffrey Cutts,Justin S. J. Hargreaves,Andrew L. Hector,Joseph A. Hriljac,William Levason,Felix Wilson Dalton Trans. 2016 45 5765
• 2. Molecular dynamics simulations of ammonium/phosphonium-based protic ionic liquids: influence of alkyl to aryl group
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• 3. The tin(ii) precursor is an active site to determine the crystal framework in CsSnI3 perovskite
  Yu Jin Kim,Dong-Won Kang J. Mater. Chem. A 2022 10 4782
• 4. Chemical transformations of quaternary ammonium salts via C–N bond cleavage
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• 5. Atomistic simulations of ammonium-based protic ionic liquids: steric effects on structure, low frequency vibrational modes and electrical conductivity
  Anurag Prakash Sunda,Anirban Mondal,Sundaram Balasubramanian Phys. Chem. Chem. Phys. 2015 17 4625

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Organic sulfonic acids and derivatives Organosulfonic acids and derivatives Alkanesulfonic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Ammonium Triflate (CAS No. 38542-94-8): An Overview of Its Properties, Applications, and Recent Research Advances

Ammonium Triflate (CAS No. 38542-94-8) is a versatile and highly efficient reagent in the field of organic synthesis and catalysis. This compound, also known as ammonium trifluoromethanesulfonate, is a white crystalline solid that is highly soluble in water and many organic solvents. Its unique properties make it an indispensable tool in various chemical processes, particularly in the synthesis of complex organic molecules and pharmaceuticals.

The chemical formula of Ammonium Triflate is NH₄OTf, where OTf represents the triflate anion (CF₃SO₃^-). The triflate anion is a strong leaving group, which makes Ammonium Triflate an excellent reagent for promoting nucleophilic substitution reactions, such as SN1 and SN2 reactions. Additionally, the triflate anion is a good counterion for forming stable salts with various cations, making it useful in the preparation of ionic liquids and other specialized materials.

In recent years, Ammonium Triflate has gained significant attention due to its applications in green chemistry and sustainable processes. One of the key advantages of this reagent is its low toxicity and environmental impact compared to traditional reagents like triflic acid (CF₃SO₃H). This has led to its increased use in industrial processes where environmental considerations are paramount.

Ammonium Triflate is also widely used as a catalyst in various organic transformations. For example, it has been shown to be an effective catalyst for the Friedel-Crafts alkylation and acylation reactions, which are fundamental steps in the synthesis of aromatic compounds. The high activity and selectivity of Ammonium Triflate in these reactions make it a preferred choice over traditional Lewis acids like aluminum chloride (AlCl₃) or boron trifluoride (BF₃). Recent studies have further explored its catalytic potential in asymmetric synthesis, where it has been used to achieve high enantioselectivities in the synthesis of chiral compounds.

Beyond its role as a reagent and catalyst, Ammonium Triflate has found applications in the preparation of advanced materials. For instance, it has been used as a dopant in the synthesis of conductive polymers and as a precursor for the preparation of metal-organic frameworks (MOFs). These materials have potential applications in areas such as gas storage, separation technologies, and catalysis.

In the pharmaceutical industry, Ammonium Triflate plays a crucial role in the synthesis of active pharmaceutical ingredients (APIs). Its ability to promote selective transformations and form stable intermediates makes it valuable in the development of new drugs. Recent research has focused on optimizing synthetic routes using Ammonium Triflate to improve yields and reduce waste, aligning with the principles of green chemistry.

The safety profile of Ammonium Triflate is another important aspect that has been extensively studied. While it is generally considered safe for use in laboratory settings when proper handling procedures are followed, it is important to note that it can be corrosive to certain materials. Therefore, appropriate personal protective equipment (PPE) should always be used when handling this compound.

In conclusion, Ammonium Triflate (CAS No. 38542-94-8) is a multifaceted compound with a wide range of applications in organic synthesis, catalysis, materials science, and pharmaceuticals. Its unique properties and low environmental impact make it an attractive choice for researchers and industrial chemists alike. As research continues to uncover new uses and improvements for this compound, its importance in various scientific fields is likely to grow even further.

• 74974-60-0(Gallium(iii) trifluoromethanesulfonate)
• 54010-75-2(Zinc(II) Trifluoromethanesulphonate)
• 2923-28-6(Trifluoromethanesulfonic acid silver)
• 54761-04-5(Ytterbium(III) Trifluoromethanesulfonate)
• 49540-00-3(Mercury(II) Triflate (2:1))
• 52093-28-4(Samarium(iii) trifluoromethanesulfonate)
• 1493-13-6(Trifluoromethanesulfonic acid)
• 33454-82-9(Trifluoromethanesulfonate lithium)
• 2926-30-9(Trifluoromethanesulfonic acid sodium)
• 74974-61-1(Aluminum trifluoromethanesulfonate)