• 1. Room-temperature conversion of CO2 into quinazoline-2,4(1H,3H)-dione using deep eutectic solvents at atmospheric pressure with high efficiency
  Yu Chen,Chong Liu,Yaoting Duan,Dongkun Yu,Zhenghui Liu,Yuting Li,Ruifen Shi,Yuting Guo,Tiancheng Mu React. Chem. Eng. 2022 7 1968
• 2. Efficient synthesis of quinazoline-2,4(1H,3H)-diones from CO2 using ionic liquids as a dual solvent–catalyst at atmospheric pressure
  Wenjing Lu,Jun Ma,Jiayin Hu,Jinliang Song,Zhaofu Zhang,Guanying Yang,Buxing Han Green Chem. 2014 16 221
• 3. Choline hydroxide promoted chemical fixation of CO2 to quinazoline-2,4(1H,3H)-diones in water
  Wenjing Lu,Jun Ma,Jiayin Hu,Zhaofu Zhang,Congyi Wu,Buxing Han RSC Adv. 2014 4 50993
• 4. Choline hydroxide promoted chemical fixation of CO2 to quinazoline-2,4(1H,3H)-diones in water
  Wenjing Lu,Jun Ma,Jiayin Hu,Zhaofu Zhang,Congyi Wu,Buxing Han RSC Adv. 2014 4 50993
• 5. Recognition and mechanistic investigation of anion sensing by ruthenium(ii) arene complexes and bio-imaging application
  Chanchal Sonkar,Sayantan Sarkar,Novina Malviya,Maxim L. Kuznetsov,Suman Mukhopadhyay Dalton Trans. 2022 51 13071

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

Comprehensive Overview of 2-Amino-4-chlorobenzonitrile (CAS No. 38487-86-4): Properties, Applications, and Industry Insights

2-Amino-4-chlorobenzonitrile (CAS No. 38487-86-4) is a versatile organic compound widely utilized in pharmaceutical, agrochemical, and material science research. Its molecular structure, characterized by an amino group (-NH₂) and a chloro substituent (-Cl) on a benzonitrile backbone, enables diverse reactivity, making it a valuable intermediate in synthetic chemistry. This article explores its physicochemical properties, synthetic routes, and emerging applications while addressing trending queries such as "green synthesis of nitrile derivatives" and "bioactive compound design."

The compound’s molecular formula, C₇H₅ClN₂, and molecular weight of 152.58 g/mol contribute to its moderate solubility in polar organic solvents like ethanol and dimethyl sulfoxide (DMSO). Researchers often highlight its melting point range (120–125°C) and stability under inert conditions, which are critical for storage and handling. Recent studies focus on optimizing catalytic amination and halogenation protocols to enhance yield and purity, aligning with industry demands for sustainable chemical processes.

In pharmaceuticals, 2-Amino-4-chlorobenzonitrile serves as a precursor for heterocyclic compounds with potential antimicrobial and antitumor activity. For instance, its integration into quinazoline and benzimidazole scaffolds has garnered attention in drug discovery, particularly for targeting kinase inhibitors. Agrochemical applications include the synthesis of crop protection agents, where its chloro-nitrogen synergy enhances pesticidal efficacy. These trends resonate with search queries like "nitrile-based agrochemicals" and "small molecule drug intermediates."

From an industrial perspective, the compound’s role in high-performance polymer synthesis is gaining traction. Its incorporation into polyamide resins improves thermal stability, addressing demands in electronics and automotive coatings. Analytical techniques such as HPLC and GC-MS are routinely employed for quality control, ensuring compliance with REACH and other regulatory standards. Discussions on "benzonitrile derivatives in material science" reflect growing interest in this niche.

Environmental and safety considerations are paramount. While 2-Amino-4-chlorobenzonitrile is not classified as hazardous under standard protocols, proper PPE (e.g., gloves, goggles) is recommended during handling. Recent advancements in biodegradation studies aim to mitigate ecological impact, aligning with the "green chemistry" movement. FAQs like "Is 2-Amino-4-chlorobenzonitrile biodegradable?" underscore this focus.

In conclusion, 2-Amino-4-chlorobenzonitrile (CAS No. 38487-86-4) exemplifies the intersection of innovation and practicality in specialty chemicals. Its adaptability across sectors—from pharmaceutical intermediates to advanced materials—positions it as a compound of enduring relevance. By addressing contemporary themes like process optimization and sustainability, this overview caters to both academic and industrial audiences seeking actionable insights.

• 53312-77-9(2-Amino-3-chlorobenzonitrile)
• 5922-60-1(2-Amino-5-chlorobenzonitrile)
• 89403-98-5(Benzonitrile, 2-amino-3,4,5-trichloro-)
• 573768-09-9(4-Amino-2-chloro-3-methylbenzonitrile (~90%))
• 158296-69-6(4-Amino-3-chloro-5-methylbenzonitrile)
• 147249-41-0(6-Amino-2,3-dichlorobenzonitrile)
• 36764-94-0(2-Amino-3,5-dichlorobenzonitrile)
• 6575-11-7(2-Amino-6-chlorobenzonitrile)
• 289686-80-2(2-amino-4-chloro-5-methylbenzonitrile)
• 53312-78-0(3-Amino-5-chlorobenzonitrile)