• 1. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151
• 4. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 5. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991

• Solvents and Organic Chemicals Organic Compounds Benzenoids Naphthalenes Naphthalenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Naphthalenes

Comprehensive Guide to 4-(4-Methoxynaphthalen-1-yl)-1,3-thiazole-2-carbaldehyde (CAS No. 383142-30-1): Properties, Applications, and Market Insights

4-(4-Methoxynaphthalen-1-yl)-1,3-thiazole-2-carbaldehyde (CAS No. 383142-30-1) is a specialized organic compound that has garnered significant attention in the fields of medicinal chemistry, material science, and agrochemical research. This compound, characterized by its unique thiazole-carbaldehyde core and methoxynaphthalene moiety, serves as a versatile building block for synthesizing more complex molecules. Its molecular structure combines the electron-rich properties of the naphthalene ring with the reactive aldehyde functional group, making it an attractive candidate for various applications.

The growing interest in 4-(4-methoxynaphthalen-1-yl)-1,3-thiazole-2-carbaldehyde is partly driven by its potential role in drug discovery. Researchers are exploring its utility as a precursor for heterocyclic compounds, which are prevalent in pharmaceuticals targeting inflammation, cancer, and infectious diseases. The thiazole ring, in particular, is a common pharmacophore found in many FDA-approved drugs, highlighting the compound's relevance in modern therapeutics.

From a synthetic chemistry perspective, CAS 383142-30-1 offers several advantages. Its aldehyde group allows for straightforward derivatization through condensation, reduction, or nucleophilic addition reactions. Meanwhile, the methoxynaphthalene component contributes to the compound's stability and influences its photophysical properties, making it potentially useful in organic electronics and fluorescent probes. These characteristics align with current trends in sustainable chemistry and green synthesis, as researchers seek efficient methods to functionalize such scaffolds.

The commercial availability of 4-(4-methoxynaphthalen-1-yl)-1,3-thiazole-2-carbaldehyde has expanded in recent years, reflecting its increasing importance in R&D. Suppliers typically offer this compound with high purity (≥95%-98%) for laboratory use, though scaling up production remains a topic of discussion among manufacturers. Pricing trends show moderate stability, with fluctuations tied to raw material costs for naphthalene derivatives and thiazole intermediates.

Analytical characterization of 383142-30-1 reveals distinct spectral features that aid in quality control. The compound exhibits characteristic 1H NMR signals around δ 9-10 ppm for the aldehyde proton and distinctive aromatic patterns from the naphthalene-thiazole system. These properties make it relatively straightforward to identify and quantify in complex mixtures, addressing common questions about compound verification in research settings.

Looking ahead, the future applications of 4-(4-methoxynaphthalen-1-yl)-1,3-thiazole-2-carbaldehyde may expand into emerging areas like metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), where its bifunctional nature could enable novel material designs. The compound's balance of aromaticity and reactivity positions it well for innovations in catalysis and molecular recognition systems, topics currently trending in materials science literature.

For researchers handling CAS 383142-30-1, standard laboratory precautions apply. While not classified as highly hazardous, proper ventilation and personal protective equipment are recommended when working with this compound, consistent with general organic chemistry safety protocols. Storage typically involves protection from light and moisture at ambient temperatures to maintain stability.

The scientific literature contains numerous references to thiazole-naphthalene hybrids similar to this compound, particularly in studies of structure-activity relationships and molecular electronics. Patent databases show increasing activity around such structures, suggesting growing commercial interest. These developments make 4-(4-methoxynaphthalen-1-yl)-1,3-thiazole-2-carbaldehyde a compound worth monitoring for both academic and industrial chemists.

In summary, 4-(4-methoxynaphthalen-1-yl)-1,3-thiazole-2-carbaldehyde (CAS No. 383142-30-1) represents an important structural motif in contemporary chemical research. Its combination of a naphthalene backbone with a thiazole-aldehyde functional group creates diverse opportunities for molecular design across multiple disciplines. As synthetic methodologies advance and applications diversify, this compound is poised to play an increasingly significant role in cutting-edge chemical innovation.

• 2362-68-7(Thiazole, 4-(4-methoxyphenyl)-2-phenyl-)
• 383142-89-0(4-(2-Methoxyphenyl)-1,3-thiazole-2-carbaldehyde)
• 75390-44-2(4-Phenyl-1,3-thiazole-2-carbaldehyde)
• 123971-42-6(Sodium 4-(4-Methoxyphenyl)-1,3-thiazole-2-carboxylate)
• 383140-93-0(4-(naphthalen-2-yl)-1,3-thiazole-2-carbaldehyde)
• 30686-73-8(4-(2-Methyl-4-thiazolyl)phenol)
• 383140-16-7(4-(5-Chloro-2-methoxy-phenyl)-thiazole-2-carbaldehyde)
• 70744-77-3(Thiazole, 4-(4-ethoxyphenyl)-2-methyl-)
• 365427-24-3(4-(3-Methoxyphenyl)-2-methyl-1,3-thiazole)
• 50834-78-1(4-(4-Methoxyphenyl)-2-methylthiazole)