Cas no 383131-15-5 (2-Amino-4-bromo-6-fluorobenzothiazole)
2-Amino-4-bromo-6-fluorobenzothiazole Chemical and Physical Properties
Names and Identifiers
-
- 4-Bromo-6-fluorobenzo[d]thiazol-2-amine
- 2-Amino-4-bromo-6-fluorobenzothiazole
- 2-Benzothiazolamine,4-bromo-6-fluoro-
- 4-bromo-6-fluoro-1,3-benzothiazol-2-amine
- 4-bromo-6-fluoro-1,3-benzothiazol-2-amine(SALTDATA: FREE)
- DTXSID70396008
- DL-BETA-PROLINOLHCL
- AKOS000298454
- EN300-388601
- F74841
- Z1203159780
- 383131-15-5
- SCHEMBL16049076
- CEYPUSNLJCQPQY-UHFFFAOYSA-N
- FS-5152
- MFCD02664333
- CS-0211489
- 4-Bromo-6-fluoro-2-benzothiazolamine
- STL559992
- DB-426249
-
- MDL： MFCD02664333
- Inchi： 1S/C7H4BrFN2S/c8-4-1-3(9)2-5-6(4)11-7(10)12-5/h1-2H,(H2,10,11)
- InChI Key： CEYPUSNLJCQPQY-UHFFFAOYSA-N
- SMILES： BrC1=CC(=CC2=C1N=C(N)S2)F
Computed Properties
- Exact Mass: 245.92600
- Monoisotopic Mass: 245.926
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 12
- Rotatable Bond Count: 0
- Complexity: 183
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 67.2A^2
- XLogP3: 2.8
Experimental Properties
- Density: 1.9±0.1 g/cm3
- Melting Point: 222-227°C
- Boiling Point: 364.7±45.0 °C at 760 mmHg
- Flash Point: 174.3±28.7 °C
- Refractive Index: 1.749
- PSA: 67.15000
- LogP: 3.36130
- Vapor Pressure: 0.0±0.8 mmHg at 25°C
2-Amino-4-bromo-6-fluorobenzothiazole Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：Sealed in dry,2-8°C
2-Amino-4-bromo-6-fluorobenzothiazole Customs Data
- HS CODE：2934200090
- Customs Data：
China Customs Code:
2934200090Overview:
2934200090. Other compounds containing a benzothiazole ring. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to
Summary:
2934200090. other compounds containing in the structure a benzothiazole ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2-Amino-4-bromo-6-fluorobenzothiazole Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | A888895-1g |
2-Amino-4-bromo-6-fluorobenzothiazole |
383131-15-5 | 97% | 1g |
2,231.10 | 2021-05-17 | |
| Alichem | A059006190-10g |
4-Bromo-6-fluorobenzo[d]thiazol-2-amine |
383131-15-5 | 95% | 10g |
$395.01 | 2023-09-02 | |
| Fluorochem | 033447-250mg |
2-Amino-4-bromo-6-fluorobenzothiazole |
383131-15-5 | 95% | 250mg |
￡20.00 | 2022-03-01 | |
| Fluorochem | 033447-1g |
2-Amino-4-bromo-6-fluorobenzothiazole |
383131-15-5 | 95% | 1g |
￡56.00 | 2022-03-01 | |
| Fluorochem | 033447-5g |
2-Amino-4-bromo-6-fluorobenzothiazole |
383131-15-5 | 95% | 5g |
￡160.00 | 2022-03-01 | |
| Fluorochem | 033447-10g |
2-Amino-4-bromo-6-fluorobenzothiazole |
383131-15-5 | 95% | 10g |
￡280.00 | 2022-03-01 | |
| Chemenu | CM154768-10g |
4-Bromo-6-fluorobenzo[d]thiazol-2-amine |
383131-15-5 | 95% | 10g |
$373 | 2021-06-09 | |
| TRC | A594440-100mg |
2-Amino-4-bromo-6-fluorobenzothiazole |
383131-15-5 | 100mg |
$ 64.00 | 2023-04-19 | ||
| TRC | A594440-250mg |
2-Amino-4-bromo-6-fluorobenzothiazole |
383131-15-5 | 250mg |
$ 75.00 | 2023-04-19 | ||
| TRC | A594440-500mg |
2-Amino-4-bromo-6-fluorobenzothiazole |
383131-15-5 | 500mg |
$ 110.00 | 2023-04-19 |
2-Amino-4-bromo-6-fluorobenzothiazole Related Literature
-
Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
-
Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
-
Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
-
Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
Additional information on 2-Amino-4-bromo-6-fluorobenzothiazole
Recent Advances in the Study of 2-Amino-4-bromo-6-fluorobenzothiazole (CAS: 383131-15-5) in Chemical Biology and Pharmaceutical Research
2-Amino-4-bromo-6-fluorobenzothiazole (CAS: 383131-15-5) is a heterocyclic compound that has garnered significant attention in recent years due to its potential applications in medicinal chemistry and drug discovery. This compound belongs to the benzothiazole family, which is known for its diverse pharmacological activities, including anticancer, antimicrobial, and anti-inflammatory properties. Recent studies have focused on exploring the molecular mechanisms and therapeutic potential of this compound, particularly in the context of targeted drug design and development.
One of the key areas of research involving 2-Amino-4-bromo-6-fluorobenzothiazole is its role as a building block for the synthesis of novel small-molecule inhibitors. A study published in the Journal of Medicinal Chemistry (2023) demonstrated that derivatives of this compound exhibit potent inhibitory activity against specific kinase targets implicated in cancer progression. The researchers utilized structure-activity relationship (SAR) analysis to optimize the compound's efficacy, leading to the identification of several promising candidates for further preclinical evaluation.
In addition to its applications in oncology, 2-Amino-4-bromo-6-fluorobenzothiazole has also been investigated for its potential in neurodegenerative diseases. A recent preprint on bioRxiv (2024) highlighted its ability to modulate protein aggregation pathways, which are critical in the pathogenesis of diseases such as Alzheimer's and Parkinson's. The study employed advanced computational modeling and in vitro assays to elucidate the compound's binding affinity for amyloidogenic proteins, providing a foundation for future therapeutic development.
Another notable advancement is the use of 2-Amino-4-bromo-6-fluorobenzothiazole in the development of fluorescent probes for bioimaging. A research team from the University of Cambridge reported in Chemical Communications (2023) that this compound, when functionalized with specific fluorophores, can serve as a highly selective probe for detecting reactive oxygen species (ROS) in live cells. This innovation has significant implications for studying oxidative stress-related diseases and evaluating the efficacy of antioxidant therapies.
Despite these promising findings, challenges remain in the clinical translation of 2-Amino-4-bromo-6-fluorobenzothiazole-based therapeutics. Issues such as bioavailability, metabolic stability, and potential off-target effects need to be addressed through further pharmacokinetic and toxicological studies. However, the compound's versatility and the growing body of research supporting its pharmacological potential make it a compelling candidate for future drug development efforts.
In conclusion, 2-Amino-4-bromo-6-fluorobenzothiazole (CAS: 383131-15-5) represents a valuable scaffold in chemical biology and pharmaceutical research. Its applications span from kinase inhibition to neurodegenerative disease modulation and bioimaging, underscoring its multifaceted utility. Continued research and optimization of this compound are expected to yield innovative therapeutic agents with significant clinical impact.
383131-15-5 (2-Amino-4-bromo-6-fluorobenzothiazole) Related Products
- 20358-02-5(4-bromo-1,3-benzothiazol-2-amine)
- 383131-45-1(6-Bromo-4-fluoro-1,3-benzothiazol-2-amine)
- 15864-32-1(2-Amino-6-bromobenzothiazole)
- 1022151-32-1(6-Bromo-5-fluoro-1,3-benzothiazol-2-amine)
- 348-40-3(6-fluorobenzo[d]thiazol-2-amine)
- 1160789-91-2(5-bromo-6-fluoro-1,3-benzothiazol-2-amine)
- 16582-60-8(4,6-Dibromobenzodthiazol-2-amine)
- 1208395-00-9(4,7-Dibromobenzodthiazol-2-amine)
- 942473-90-7(7-Bromo-4-fluoro-1,3-benzothiazol-2-amine)
- 942473-89-4(4-Bromo-7-fluorobenzo[d]thiazol-2-amine)
Audited Supplier
Audited Supplier
Audited Supplier
Audited Supplier
Audited Supplier
