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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Phenylpiperidines

Comprehensive Overview of 2-(4-Bromophenyl)piperidine (CAS No. 383128-14-1): Properties, Applications, and Research Insights

2-(4-Bromophenyl)piperidine (CAS No. 383128-14-1) is a brominated aromatic compound featuring a piperidine moiety, which has garnered significant attention in pharmaceutical and chemical research. This compound belongs to the class of arylpiperidine derivatives, known for their versatile applications in drug discovery and material science. Its molecular structure combines a 4-bromophenyl group with a piperidine ring, offering unique reactivity and functionalization potential. Researchers often explore its role as a building block in synthesizing complex molecules, particularly in the development of central nervous system (CNS) targeting agents.

The growing interest in 2-(4-Bromophenyl)piperidine is reflected in its frequent appearance in scientific literature and patent filings. A key driver of this trend is the demand for novel heterocyclic compounds in medicinal chemistry, where piperidine derivatives are prized for their bioactivity. Recent studies highlight its utility in designing ligands for receptor modulation, especially in neurological disorders. For instance, its structural motif is found in compounds under investigation for neurodegenerative disease therapeutics, aligning with the global focus on brain health innovations.

From a synthetic perspective, CAS No. 383128-14-1 serves as a pivotal intermediate in multi-step organic reactions. Its bromine substituent enables cross-coupling reactions like Suzuki-Miyaura or Buchwald-Hartwig amination, making it valuable for constructing biaryl architectures. This adaptability resonates with the current emphasis on green chemistry and atom-efficient methodologies, as researchers seek sustainable pathways for complex molecule assembly. Laboratories frequently pair this compound with catalytic systems to achieve high-yield transformations.

Analytical characterization of 2-(4-Bromophenyl)piperidine typically involves techniques such as NMR spectroscopy, HPLC purity analysis, and mass spectrometry. These methods confirm its structural integrity and suitability for downstream applications. Notably, its physicochemical properties—including solubility in organic solvents and thermal stability—make it compatible with diverse reaction conditions. Such data is crucial for industrial-scale applications, where process optimization and quality control are paramount.

Beyond pharmaceuticals, this compound finds niche applications in material science, particularly in designing organic electronic components. The 4-bromophenyl segment contributes to π-conjugation, a desirable trait for conductive polymers or light-emitting diodes (OLEDs). This intersection with next-generation materials aligns with the surge in searches for advanced functional materials and energy-efficient technologies.

Safety and handling protocols for 383128-14-1 emphasize standard laboratory practices, given its classification as a non-hazardous research chemical under normal conditions. However, proper personal protective equipment (PPE) and ventilation are recommended during handling, reflecting the broader industry shift toward responsible chemical management. Regulatory compliance, including REACH and DSL listings, ensures its lawful use across jurisdictions.

In summary, 2-(4-Bromophenyl)piperidine exemplifies the synergy between structural elegance and functional utility. Its relevance spans drug discovery pipelines, catalysis research, and smart material development, addressing contemporary challenges in science and technology. As interest in tailored heterocycles grows, this compound will likely remain a cornerstone in innovative chemical solutions.

• 1189152-82-6((2S)-2-(4-Bromophenyl)pyrrolidine)
• 1241681-35-5((S)-2-(4-Bromo-3-methylphenyl)piperidine)
• 383128-74-3(2-(3-Bromophenyl)piperidine)
• 1228557-30-9(2-(4-Bromo-phenyl)-piperidine)
• 1228557-44-5((S)-2-(3-Bromophenyl)piperidine)
• 405315-59-5(INDOLIZINE, 5-(4-BROMOPHENYL)OCTAHYDRO-)
• 383127-22-8(2-(4-Bromophenyl)pyrrolidine)
• 383129-24-6(2-(4-Bromophenyl)azepane)
• 1228559-45-2((S)-2-(4-Bromophenyl)piperidine)
• 1189155-63-2((2R)-2-(4-bromophenyl)pyrrolidine)