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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Phenylpiperidines

Comprehensive Overview of 2-(4-Fluorophenyl)piperidine (CAS No. 383128-03-8): Properties, Applications, and Industry Insights

2-(4-Fluorophenyl)piperidine (CAS No. 383128-03-8) is a fluorinated piperidine derivative that has garnered significant attention in pharmaceutical and chemical research due to its unique structural properties. This compound, characterized by a piperidine ring substituted with a 4-fluorophenyl group, serves as a versatile intermediate in organic synthesis. Researchers and industry professionals frequently search for terms like "2-(4-Fluorophenyl)piperidine synthesis," "CAS 383128-03-8 applications," and "fluorinated piperidine derivatives," reflecting its relevance in modern chemistry.

The growing interest in fluorinated compounds stems from their enhanced bioavailability and metabolic stability, making them pivotal in drug discovery. 2-(4-Fluorophenyl)piperidine is often explored for its potential role in central nervous system (CNS) therapeutics, aligning with trending topics such as "neuropharmacology research 2024" and "small molecule drug development." Its molecular structure, featuring a fluorine atom at the para position of the phenyl ring, contributes to improved binding affinity in target proteins, a hot topic in "structure-activity relationship (SAR) studies."

From a synthetic chemistry perspective, CAS 383128-03-8 is typically prepared via nucleophilic substitution or catalytic hydrogenation methods. Recent advancements in "green chemistry" have spurred interest in optimizing its production using eco-friendly catalysts, addressing concerns around sustainable manufacturing. Searches like "piperidine derivatives solvent-free synthesis" highlight this shift. Analytical techniques such as HPLC and NMR are critical for purity validation, ensuring compliance with industry standards like ICH Q3D for elemental impurities.

The compound's stability under varying pH conditions makes it suitable for formulation studies, particularly in "oral bioavailability enhancement," a key focus area for pharmaceutical developers. Discussions on platforms like ResearchGate often highlight its compatibility with "lipid-based drug delivery systems," linking to broader trends in "nanomedicine." Regulatory databases indicate that 2-(4-Fluorophenyl)piperidine is not classified under restricted categories, though proper handling per OSHA guidelines is recommended during lab-scale operations.

Emerging applications include its use as a scaffold in "covalent inhibitor design," particularly for kinase targets—a trending subject in "cancer therapeutics." Patent analyses reveal growing IP activity around fluorinated piperidines, with queries like "CAS 383128-03-8 patent landscape" gaining traction. The compound's logP value (predicted ~2.8) suggests favorable membrane permeability, explaining its utility in blood-brain barrier penetration studies.

In summary, 2-(4-Fluorophenyl)piperidine represents a critical building block in medicinal chemistry, bridging academic research and industrial applications. Its alignment with high-demand research areas—from "preclinical drug candidates" to "sustainable synthetic routes"—ensures continued relevance. For researchers, staying updated on purification protocols (e.g., "recrystallization solvents for 383128-03-8") and safety data sheets (SDS) remains essential for optimal utilization.

• 298690-89-8((2R)-2-(4-fluorophenyl)pyrrolidine)
• 1228542-46-8((S)-2-(3-Fluorophenyl)piperidine)
• 383130-06-1(2-(3-Fluorophenyl)azepane)
• 127529-41-3(Piperidine, 1-[1-(4-fluorophenyl)-2-phenylethyl]-, (±)-)
• 168890-44-6(2-(4-Fluorophenyl)azepane)
• 1187173-24-5(2-(3-Fluorophenyl)piperidine hydrochloride)
• 1187174-10-2(2-(4-fluorophenyl)piperidine hydrochloride)
• 1187468-22-9((2S)-2-(4-fluorophenyl)piperidine)
• 1187468-21-8((2R)-2-(4-fluorophenyl)piperidine)
• 383128-42-5(2-(3-Fluorophenyl)piperidine)