• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 4. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

Exploring the Versatile Applications and Properties of Ethyl 3-formyl-1-benzofuran-2-carboxylate (CAS No. 38281-60-6)

Ethyl 3-formyl-1-benzofuran-2-carboxylate (CAS No. 38281-60-6) is a highly specialized organic compound that has garnered significant attention in the fields of pharmaceutical research, material science, and synthetic chemistry. This compound, characterized by its unique benzofuran core and functional groups, serves as a pivotal intermediate in the synthesis of complex molecules. Its formyl and ester moieties make it a versatile building block for designing novel compounds with potential applications in drug discovery and advanced materials.

In recent years, the demand for benzofuran derivatives like ethyl 3-formyl-1-benzofuran-2-carboxylate has surged due to their role in developing bioactive molecules. Researchers are particularly interested in its potential as a precursor for anticancer agents, antioxidants, and anti-inflammatory drugs. The compound's ability to undergo diverse chemical transformations, such as condensation reactions and nucleophilic substitutions, makes it invaluable for constructing heterocyclic frameworks. This aligns with the growing trend of green chemistry and sustainable synthesis, where efficiency and minimal environmental impact are prioritized.

From a structural perspective, CAS No. 38281-60-6 features a benzofuran ring substituted with an aldehyde group at the 3-position and an ethyl ester at the 2-position. This arrangement not only enhances its reactivity but also improves its solubility in organic solvents, facilitating its use in multistep synthetic routes. The compound's molecular weight and physicochemical properties have been extensively studied, with data available in prominent chemical databases like PubChem and Reaxys. Such accessibility supports its adoption in both academic and industrial settings.

The synthesis of ethyl 3-formyl-1-benzofuran-2-carboxylate typically involves the Vilsmeier-Haack reaction or oxidation of corresponding precursors, showcasing its compatibility with established organic synthesis protocols. Its stability under standard conditions further underscores its practicality for large-scale production. Moreover, the compound's spectroscopic data (e.g., NMR, IR, and mass spectrometry) are well-documented, aiding in quality control and structural verification.

Beyond pharmaceuticals, 38281-60-6 has found niche applications in material science, particularly in the development of organic semiconductors and fluorescent probes. Its conjugated system and electron-withdrawing groups contribute to desirable electronic properties, making it a candidate for optoelectronic devices. This resonates with the rising interest in renewable energy technologies and smart materials, where researchers seek innovative compounds to enhance performance.

In conclusion, ethyl 3-formyl-1-benzofuran-2-carboxylate (CAS No. 38281-60-6) exemplifies the intersection of chemistry and innovation. Its multifaceted applications, from drug development to advanced materials, highlight its importance in modern scientific endeavors. As the scientific community continues to explore its potential, this compound remains a cornerstone in the quest for sustainable and high-value chemical solutions.

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• 2076-36-0(3-Methylbenzofuran-2-carboxylic Acid Methyl Ester)
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• 87968-31-8(2,3-BENZOFURANDICARBOXYLIC ACID, 5,6-DIMETHYL-, DIMETHYL ESTER)