• 1. Electrochemical characterization and thermodynamic analysis of TEMPO derivatives in ionic liquids
  Luke Wylie,Kan Hakatayama-Sato,Choitsu Go,Kenichi Oyaizu,Ekaterina I. Izgorodina Phys. Chem. Chem. Phys. 2021 23 10205
• 2. α-CO provides access to the cavity in acyl calix[4]arenes: A comparative study of crystal structures
  Michaela Pojarova,Gennady S. Ananchenko,Konstantin A. Udachin,Florent Perret,Anthony W. Coleman,John A. Ripmeester New J. Chem. 2007 31 871
• 3. Electrolyte additives for lithium ion battery electrodes: progress and perspectives
  Atetegeb Meazah Haregewoin,Aselefech Sorsa Wotango,Bing-Joe Hwang Energy Environ. Sci. 2016 9 1955
• 4. para-Acylcalix[n]arenes: from molecular to macroscopic assemblies
  Anthony W. Coleman,Said Jebors,Patrick Shahgaldian,Gennady S. Ananchenko,John A. Ripmeester Chem. Commun. 2008 2291
• 5. Fundamental properties of TEMPO-based catholytes for aqueous redox flow batteries: effects of substituent groups and electrolytes on electrochemical properties, solubilities and battery performance
  Wenbo Zhou,Wenjie Liu,Meng Qin,Zhidong Chen,Juan Xu,Jianyu Cao,Jun Li RSC Adv. 2020 10 21839

• Material Chemicals Electrical Materials Biosensor Materials
• Material Chemicals Electrical Materials

Comprehensive Guide to 4-Cyano-TEMPO (CAS No. 38078-71-6): Properties, Applications, and Research Trends

4-Cyano-TEMPO (CAS No. 38078-71-6), also known as 4-CT or 4-Cyano-2,2,6,6-tetramethylpiperidine-1-oxyl, is a nitroxide radical compound widely recognized for its unique chemical properties and versatile applications in organic synthesis, materials science, and biomedical research. As a derivative of TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl), this compound features a cyano (-CN) functional group at the 4-position, enhancing its reactivity and utility in oxidation reactions and spin-labeling studies.

The growing interest in 4-Cyano-TEMPO stems from its role as a stable radical, making it invaluable in free-radical polymerization, redox catalysis, and antioxidant research. Researchers frequently search for "4-Cyano-TEMPO solubility," "4-CT synthesis methods," and "TEMPO derivatives comparison," reflecting its relevance in both academic and industrial settings. Its CAS No. 38078-71-6 is a critical identifier for procurement and regulatory compliance.

One of the most discussed applications of 4-Cyano-TEMPO is in organic battery electrolytes, where it acts as a redox mediator to improve charge efficiency. This aligns with the global push for sustainable energy solutions, a topic dominating scientific and public discourse. Additionally, its use in bioconjugation and protein labeling has gained traction, particularly in proteomics and drug discovery.

From a structural perspective, the cyano group in 4-Cyano-TEMPO offers distinct advantages over other TEMPO analogs. It increases electron-withdrawing effects, which can fine-tune redox potentials—a feature exploited in electrochemical sensors and conductive polymers. Recent studies also highlight its potential in photocatalysis, addressing the demand for greener chemical processes.

For those exploring "4-Cyano-TEMPO stability" or "handling precautions," it’s important to note that the compound is typically stored under inert conditions due to its radical nature. However, it remains non-hazardous under standard laboratory practices, making it accessible for diverse research applications. Its melting point (~90–95°C) and solubility in polar solvents (e.g., acetonitrile, DMSO) are frequently cited in experimental protocols.

In summary, 4-Cyano-TEMPO (CAS No. 38078-71-6) bridges gaps between fundamental chemistry and cutting-edge technologies. Whether investigating "nitroxide radicals in medicine" or "advanced oxidation catalysts," this compound continues to inspire innovation across disciplines. Its adaptability ensures it remains a staple in the toolkit of chemists and material scientists worldwide.

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