• 1. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 2. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 3. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes

Comprehensive Guide to (3-Bromo-5-nitrophenyl)boronic acid (CAS No. 380430-48-8): Properties, Applications, and Industry Insights

(3-Bromo-5-nitrophenyl)boronic acid (CAS No. 380430-48-8) is a highly versatile boronic acid derivative widely utilized in organic synthesis, pharmaceutical research, and material science. This compound, characterized by its bromine and nitro functional groups, plays a pivotal role in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern drug discovery and agrochemical development. Its unique molecular structure enables precise modifications, making it invaluable for designing small-molecule inhibitors and functional materials.

The growing demand for high-purity boronic acids like 380430-48-8 is driven by advancements in targeted cancer therapies and bioconjugation techniques. Researchers frequently search for "how to optimize Suzuki coupling with nitrophenyl boronic acids" or "stable boronic acid derivatives for sensor development," reflecting its relevance in cutting-edge applications. This compound’s electron-withdrawing nitro group enhances reactivity in palladium-catalyzed reactions, while the bromine substituent offers further functionalization opportunities.

In the context of green chemistry, (3-Bromo-5-nitrophenyl)boronic acid aligns with trends toward atom-efficient synthesis. A 2023 study highlighted its use in constructing biaryl scaffolds for OLED materials, addressing queries like "boronic acids in renewable energy applications." Its stability under aqueous conditions also makes it suitable for biomedical probes, a topic gaining traction in diagnostic tool forums.

From a commercial perspective, suppliers emphasize CAS 380430-48-8’s role in high-throughput screening libraries. Industry reports note its inclusion in kinase inhibitor pipelines, responding to searches such as "boronic acid-based drug candidates 2024." Proper storage (desiccated, 2-8°C) and handling protocols are critical to maintain its reaction efficiency, a frequent concern among synthetic chemists.

Emerging applications include covalent organic frameworks (COFs), where this compound’s rigid aromatic backbone contributes to porous material design. Its X-ray crystallography data (PubChem CID: 11349876) supports molecular modeling studies, often cited in "computational chemistry" discussions. As AI-driven drug design accelerates, 380430-48-8 serves as a key building block for machine-learning-optimized compounds.

Regulatory compliance for (3-Bromo-5-nitrophenyl)boronic acid focuses on REACH certification and laboratory safety standards. Unlike restricted precursors, its use falls under general research chemicals guidelines, with MSDS emphasizing glove box protocols. This positions it favorably against alternatives in academic-industrial collaborations.

Future directions may exploit its photophysical properties for bioimaging tags, a hotspot in "next-gen fluorescence probes" research. With a molecular weight of 246.83 g/mol and ≥95% HPLC purity typically available, this compound remains indispensable for innovators tackling challenges from antibiotic resistance to flexible electronics.

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