Cas no 380335-72-8 (4-Chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide)

4-Chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide is a sulfonamide derivative characterized by its chloro and nitro functional groups, which contribute to its reactivity and potential applications in organic synthesis and pharmaceutical intermediates. The compound's structure, featuring an ethyl and phenyl substitution on the sulfonamide nitrogen, enhances its steric and electronic properties, making it useful for selective chemical transformations. Its nitro group offers opportunities for further functionalization, while the chloro substituent provides a handle for cross-coupling reactions. This compound is valued in research settings for its versatility in constructing complex molecules, particularly in medicinal chemistry and agrochemical development. Proper handling and storage are recommended due to its reactive nature.
4-Chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide structure
380335-72-8 structure
Product Name:4-Chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide
CAS No:380335-72-8
MF:C14H13ClN2O4S
MW:340.782021284103
CID:1487702
PubChem ID:5019418
Update Time:2025-10-29

4-Chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide Chemical and Physical Properties

Names and Identifiers

    • Benzenesulfonamide, 4-chloro-N-ethyl-3-nitro-N-phenyl-
    • 12W-0028
    • MFCD02724844
    • 380335-72-8
    • 4-chloro-N-ethyl-3-nitro-N-phenylbenzene-1-sulfonamide
    • SCHEMBL5464617
    • 4-chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide
    • AB00710649-01
    • 4-Chloro-N-ethyl-3-nitro-N-phenyl-benzenesulfonamide
    • EN300-01560
    • Z45510479
    • AKOS000115083
    • ZQNDSTJXPOGQQT-UHFFFAOYSA-N
    • CS-0218629
    • 4-Chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide
    • Inchi： 1S/C14H13ClN2O4S/c1-2-16(11-6-4-3-5-7-11)22(20,21)12-8-9-13(15)14(10-12)17(18)19/h3-10H,2H2,1H3
    • InChI Key： ZQNDSTJXPOGQQT-UHFFFAOYSA-N
    • SMILES： ClC1C=CC(=CC=1[N+](=O)[O-])S(N(C1C=CC=CC=1)CC)(=O)=O

Computed Properties

  • Exact Mass: 340.02859
  • Monoisotopic Mass: 340.0284558g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 22
  • Rotatable Bond Count: 4
  • Complexity: 482
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.5
  • Topological Polar Surface Area: 91.6?2

Experimental Properties

  • PSA: 80.52

4-Chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide Pricemore >>

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4-Chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide Related Literature

Related Categories

Additional information on 4-Chloro-N-ethyl-3-nitro-N-phenylbenzenesulfonamide

4-Chloro-N-Ethyl-3-Nitro-N-Phenylbenzenesulfonamide (CAS No 380335-72-8)

The compound 4-Chloro-N-Ethyl-3-Nitro-N-Phenylbenzenesulfonamide, identified by the CAS registry number CAS No 380335-72-8, is a complex organic molecule with significant potential in various chemical and pharmaceutical applications. This sulfonamide derivative is characterized by its unique structure, which includes a benzene ring substituted with chlorine, nitro, and sulfonamide groups, along with ethyl and phenyl substituents attached to the nitrogen atom of the sulfonamide group.

Recent studies have highlighted the importance of sulfonamides in drug design due to their ability to act as bioisosteres of carboxylic acids and their potential to modulate enzyme activity. The presence of electron-withdrawing groups like chlorine and nitro on the benzene ring further enhances the molecule's reactivity and selectivity, making it a promising candidate for various biological assays.

The synthesis of 4-Chloro-N-Ethyl-3-Nitro-N-Phenylbenzenesulfonamide typically involves multi-step reactions, including nucleophilic aromatic substitution and coupling reactions. Researchers have explored various reaction conditions to optimize yield and purity, with some studies focusing on the use of microwave-assisted synthesis to accelerate reaction times while maintaining product quality.

In terms of applications, this compound has shown potential in the field of medicinal chemistry as a lead compound for anti-inflammatory and anti-cancer drug development. Preclinical studies have demonstrated its ability to inhibit specific enzymes involved in inflammatory pathways, suggesting its potential as a therapeutic agent.

Moreover, the compound's stability under various pH conditions and its ability to penetrate cellular membranes make it an attractive candidate for drug delivery systems. Recent advancements in nanotechnology have enabled researchers to encapsulate this compound within lipid nanoparticles, enhancing its bioavailability and reducing systemic toxicity.

From an environmental perspective, understanding the degradation pathways of CAS No 380335-72-8 is crucial for assessing its ecological impact. Studies have shown that under aerobic conditions, the compound undergoes hydrolysis at a moderate rate, with the sulfonamide group playing a significant role in stabilizing the molecule against rapid degradation.

In conclusion, 4-Chloro-N-Ethyl-3-Nitro-N-Phenylbenzenesulfonamide (CAS No 380335-72-8) represents a versatile molecule with diverse applications across multiple scientific disciplines. Its unique chemical structure, coupled with recent advancements in synthetic methodologies and biological evaluations, positions it as a valuable tool in both academic research and industrial development.

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