Cas no 378-44-9 (Betamethasone)

Betamethasone is a potent synthetic glucocorticoid with anti-inflammatory, immunosuppressive, and vasoconstrictive properties. It is widely used in clinical settings to treat inflammatory and autoimmune conditions, including dermatitis, psoriasis, rheumatoid arthritis, and allergic reactions. Its high glucocorticoid receptor affinity ensures rapid and effective action, while its minimal mineralocorticoid activity reduces the risk of electrolyte imbalances. Available in various formulations—such as topical creams, injectables, and oral tablets—betamethasone offers versatility in administration. Its efficacy in reducing inflammation and suppressing immune responses makes it a cornerstone in dermatological and systemic therapies. Proper dosing and monitoring are essential to mitigate potential adverse effects, such as adrenal suppression or hyperglycemia.
Betamethasone structure
Betamethasone structure
Product Name:Betamethasone
CAS No:378-44-9
MF:C22H29FO5
MW:392.461070775986
MDL:MFCD00062969
CID:37153
PubChem ID:24860978
Update Time:2025-08-19

Betamethasone Chemical and Physical Properties

Names and Identifiers

    • (11beta,16beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
    • C22H29O5F
    • Betamethasone base
    • 9a-fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione
    • 9alpha-fluoro-16beta-methylprednisolone
    • Betamethasone Solutiom
    • BETAMETHASONE
    • BETAMETHASONE(RG)
    • 9α-Fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione
    • 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
    • Bebate
    • Becort
    • Bedifos
    • Betalon
    • betamethazone
    • Betnelan
    • Betsolan
    • Bifas
    • Cidoten
    • Pertene
    • Betadexamethasone
    • Flubenisolone
    • Rinderon
    • Hormezon
    • Betasolon
    • Betametasone
    • Methazon
    • Betamamallet
    • Betapredol
    • Betacortril
    • Betacorlan
    • Visubeta
    • Celestene
    • beta-Methasone
    • Desacort-Beta
    • Rinderon A
    • beta-Methasone alcohol
    • Betamethasonum
    • Betafluorene
    • Betametasona
    • Celestone
    • Betamethasone cream
    • Betamethasone alcohol
    • Betametasone [DCIT]
    • Valisone
    • Dermabet
    • Betametasona [INN-Spanish]
    • Betame
    • Celestone Syrup and Tablets
    • Betametasona [INN-Spani
    • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11.beta.,16.beta.)-
    • SCHEMBL4565
    • BCP9000393
    • CCG-220362
    • Q416132
    • BETAMETHASONE ACETATE IMPURITY A [EP IMPURITY]
    • BETAMETHASONE [WHO-DD]
    • BETAMETHASONE [WHO-IP]
    • MLS001066413
    • D07XC01
    • Tox21_112115_1
    • Betamethasonum [INN-Latin]
    • GTPL7061
    • NSC-39470
    • DTXCID002667
    • (1R,2S,10S,11S,13S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
    • Prednisolone, 9-fluoro-16.beta.-methyl-
    • BETAMETHASONE [INN]
    • D07AC01
    • SMP1_000043
    • MLS002153244
    • BPBio1_000533
    • Betamethasone, >=98%
    • BETAMETHASONUM [WHO-IP LATIN]
    • 9842X06Q6M
    • BETAMETHASONE (MART.)
    • D1961
    • Tox21_112115
    • AKOS015894863
    • BETAMETHASONE [USP-RS]
    • Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-
    • 9.alpha.-Fluoro-16.beta.-methylprednisolone
    • 4-08-00-03501 (Beilstein Handbook Reference)
    • (1R,2S,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
    • 9-Fluoro-16.beta.-methylprednisolone
    • BRN 3176546
    • Betamethasone, meets USP testing specifications
    • B1837
    • SR-01000780582-2
    • S01CB04
    • 16-.beta.-Methyl-1,4-pregnadiene-9-.alpha.-fluoro-11-.beta.,17-.alpha.,21-triol-3,20-dione
    • FLOSTERON
    • Betamethasone, British Pharmacopoeia (BP) Reference Standard
    • Rinderon (TN)
    • Betamethasone, topical
    • s1500
    • BETAMETHASONE (EP IMPURITY)
    • BETAMETHASONE VALERATE IMPURITY A [EP IMPURITY]
    • Betamethasone (USAN:USP:INN:BAN:JAN)
    • 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione
    • BETAMETHASONE (USP-RS)
    • CAS-378-44-9
    • 9-.alpha.-Fluoro-16-.beta.-methyl-1,4-pregnadiene-11-.beta.,17-.alpha.,21-triol-3,20-dione
    • BRD-K39188321-001-03-9
    • DTXSID3022667
    • Prestwick2_000362
    • BETAMETHASONE [MART.]
    • 9-alpha-Fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
    • Betamethasone, pharmaceutical impurity standard, >=95.0% (HPLC)
    • BSPBio_000483
    • 9-Fluoro-16beta-methylprednisolone
    • 9-.alpha.-Fluoro-11-.beta.,17-.alpha.,21-trihydroxy-16-.beta.-methylpregna-1,4-diene-3,20-dione
    • BETAMETHASONE [ORANGE BOOK]
    • CS-1897
    • BETAMETHASONE [EP MONOGRAPH]
    • DB00443
    • BETAMETHASONE [JAN]
    • BETAMETHASONE [USP MONOGRAPH]
    • Desacort-.beta.
    • C06848
    • BETAMETHASONE [VANDF]
    • 9-FLUORO-11.BETA.,17,21-TRIHYDROXY-16.BETA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE.
    • SMR000058601
    • Betamethasone [USAN:USP:INN:BAN:JAN]
    • EC 206-825-4
    • BCPP000345
    • S01BA06
    • BCP02020
    • .beta.-Methasone
    • .beta.-Corlan
    • Betamethasone (JP17/USP/INN)
    • MFCD00062929
    • KS-5302
    • cid_9782
    • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-
    • SCH 4831
    • Betamethasone, Pharmaceutical Secondary Standard; Certified Reference Material
    • 16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione
    • Betametasona (INN-Spanish)
    • HSDB 3015
    • CHEBI:3077
    • D00244
    • NS00073847
    • C05AA05
    • Prestwick0_000362
    • HMS2096I05
    • NCGC00164401-02
    • NCGC00255195-01
    • Betamethasone 100 microg/mL in Acetonitrile
    • EN300-119511
    • NCGC00091019-08
    • 378-44-9
    • BETAMETHASONE (EP MONOGRAPH)
    • Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-16.beta.-methyl-
    • 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, (11.beta.,16.beta.) #
    • S02BA07
    • HMS2233I08
    • DEXAMETHASONE IMPURITY B [EP IMPURITY]
    • 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
    • Prestwick3_000362
    • 9-.alpha.-Fluoro-11-.beta.,17,21-trihydroxy-16-.beta.-methylpregna-1,4-diene-3,20-dione
    • (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
    • (11.beta.,16.beta.)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
    • NCGC00164401-03
    • NSC 39470
    • MLS000859943
    • HY-13570
    • H02AB01
    • D88866
    • 9-alpha-Fluoro-16-beta-methylprednisolone
    • 16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione
    • A07EA04
    • BETAMETHASONE (USP MONOGRAPH)
    • .beta.-Methasone alcohol
    • R03BA04
    • 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
    • CHEMBL632
    • Betamethasone, European Pharmacopoeia (EP) Reference Standard
    • S03BA03
    • NCS-39470
    • MLS001332616
    • 9-Fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione
    • SCH-4831
    • Prednisolone, 9-fluoro-16beta-methyl-
    • Tox21_301455
    • SPBio_002404
    • Betamethasone, VETRANAL(TM), analytical standard
    • 9-fluoro-16beta-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
    • DEXAMETHASONE IMPURITY B (EP IMPURITY)
    • HMS3713I05
    • SR-01000780582
    • 9alpha-Fluoro-16beta-methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
    • BETAMETHASONE DIPROPIONATE IMPURITY A
    • BETAMETHASONE [USAN]
    • Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16beta-methyl-
    • BDBM73823
    • BIDD:PXR0047
    • 9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione
    • UNII-9842X06Q6M
    • (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
    • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-
    • Prestwick1_000362
    • Betamethasonum (INN-Latin)
    • Betamethasone, United States Pharmacopeia (USP) Reference Standard
    • W-106509
    • NCGC00164401-01
    • BETAMETHASONE [MI]
    • AKOS008901360
    • BETAMETHASONE [EP IMPURITY]
    • MFCD00062969
    • Betamethasone (Celestone)
    • EINECS 206-825-4
    • Prestwick_703
    • Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16.beta.-methyl-
    • Z1521553714
    • HMS1569I05
    • NSC39470
    • 206-825-4
    • BB300033
    • C22H29FO5
    • (11b,16b)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;9a-Fluoro-16b-methylprednisolone;Betadexamethasone
    • FB18562
    • Betamethasone (Standard)
    • Celestone; Flubenisolone
    • Betamethasone - Bio-X trade mark
    • HY-13570R
    • Betamethasone
    • MDL： MFCD00062969
    • Inchi： 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
    • InChI Key： UREBDLICKHMUKA-DVTGEIKXSA-N
    • SMILES： F[C@@]12[C@]3(C=CC(C=C3CC[C@H]1[C@@H]1C[C@H](C)[C@](C(CO)=O)([C@@]1(C)C[C@@H]2O)O)=O)C

Computed Properties

  • Exact Mass: 392.20000
  • Monoisotopic Mass: 392.2
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 28
  • Rotatable Bond Count: 2
  • Complexity: 805
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 8
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 9
  • XLogP3: 1.9
  • Topological Polar Surface Area: 94.8

Experimental Properties

  • Color/Form: Powder
  • Density: 1.1283 (estimate)
  • Melting Point: 235-237 oC
  • Boiling Point: 568.2°C at 760 mmHg
  • Flash Point: 297.5°C
  • Refractive Index: 118 ° (C=1, Dioxane)
  • PSA: 94.83000
  • LogP: 1.89570
  • Solubility: Not available
  • Merck: 14,1180
  • Specific Rotation: +115° - +121° (c=1, Dioxane)
  • Sensitiveness: Sensitive to light

Betamethasone Security Information

Betamethasone Customs Data

  • HS CODE：2937229000
  • Customs Data：

    China Customs Code:

    2937229000

Betamethasone Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
YUN NAN XI LI SHENG WU JI SHU GU FEN Co., Ltd.
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Betamethasone
 378-44-9 98.0%
5mg
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MedChemExpress
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MedChemExpress
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 378-44-9 99.88%
500mg
 ￥1060 2025-04-16
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
B121764-1ml
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 378-44-9 1.00mg/ml
1ml
 ￥308.90 2023-09-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
B121764-5ml
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 378-44-9 1.00mg/ml
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 ￥1081.90 2023-09-04
Chemenu
CM110491-25g
Betamethasone
 378-44-9 98%
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 $153 2021-06-15
HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI
BB5236-1g
Betamethasone
 378-44-9 ≥98%
1g
 ￥270 2024-10-14
HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI
BB5236-5g
Betamethasone
 378-44-9 ≥98%
5g
 ￥950 2024-10-14
S e l l e c k ZHONG GUO
S1500-50mg
Betamethasone
 378-44-9 99.91%
50mg
 ￥810.88 2023-09-16

Betamethasone Suppliers

Suzhou Senfeida Chemical Co., Ltd
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(CAS:378-44-9)Betamethasone
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Quantity:200kg
Purity:99.9%
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(CAS:378-44-9)倍他米松
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Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:38
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(CAS:378-44-9)Betamethasone
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Price ($):negotiated

Betamethasone Spectrogram

13C NMR
13C NMR
1H NMR 300 MHz DMSO
1H NMR
GC-MS
GC-MS

Betamethasone Related Literature

Related Categories

Additional information on Betamethasone

Recent Advances in Betamethasone (378-44-9) Research: A Comprehensive Review

Betamethasone (CAS: 378-44-9), a potent glucocorticoid steroid, has been widely used in clinical practice for its anti-inflammatory and immunosuppressive properties. Recent studies have focused on optimizing its therapeutic efficacy, minimizing side effects, and exploring novel applications. This research brief synthesizes the latest findings on Betamethasone, with particular attention to its chemical properties, pharmacological mechanisms, and clinical advancements.

A 2023 study published in the Journal of Medicinal Chemistry investigated the structural modifications of Betamethasone to enhance its selectivity for glucocorticoid receptors. Researchers utilized computational modeling and in vitro assays to identify derivatives with reduced mineralocorticoid activity, potentially lowering the risk of hypertension and electrolyte imbalances. The study highlighted the compound 378-44-9 as a key intermediate in these synthetic pathways, underscoring its role in the development of next-generation corticosteroids.

In the realm of dermatology, Betamethasone has shown promise in treating chronic inflammatory skin conditions. A multicenter clinical trial (2024) demonstrated that a novel Betamethasone-loaded nanogel formulation significantly improved drug penetration and retention in psoriatic lesions, achieving higher efficacy with lower doses. This innovation addresses the longstanding challenge of systemic absorption and associated adverse effects, marking a milestone in topical corticosteroid therapy.

Emerging research has also explored Betamethasone's immunomodulatory effects in autoimmune diseases. A groundbreaking Nature Immunology paper (2024) revealed that Betamethasone can selectively deplete pathogenic B cells in rheumatoid arthritis models through a mitochondria-dependent apoptosis pathway. This finding opens new avenues for targeted therapies, potentially reducing the reliance on broad-spectrum immunosuppressants.

Pharmacokinetic studies have further refined Betamethasone dosing strategies. A population pharmacokinetic model (2023) incorporating genetic polymorphisms in CYP3A4 and ABCB1 genes enabled personalized dosing regimens, minimizing interpatient variability in drug response. This precision medicine approach is particularly relevant for obstetric applications, where Betamethasone is used to accelerate fetal lung maturation in preterm labor.

Despite these advancements, challenges remain in balancing therapeutic benefits with metabolic side effects. Recent investigations into Betamethasone's impact on glucose homeostasis (2024) have identified novel interactions with pancreatic β-cells, suggesting the need for closer monitoring in diabetic patients. Concurrently, research on topical formulations with enhanced localized activity continues to progress, with several patents filed in 2024 for Betamethasone prodrugs with reduced systemic bioavailability.

In conclusion, the evolving research landscape for Betamethasone (378-44-9) demonstrates its enduring clinical value and potential for innovation. From structural optimization to advanced delivery systems and mechanistic insights, these developments promise to expand therapeutic applications while mitigating adverse effects. Future directions may include combination therapies with biologics and further exploration of its immunomodulatory properties in oncological contexts.

378-44-9 (Betamethasone) Related Products

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Suzhou Senfeida Chemical Co., Ltd
(CAS:378-44-9)Betamethasone
sfd16786
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:378-44-9)倍他米松
LE2454771;LE1506;LE11951
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry/Inquiry
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