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  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 2. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

Introduction to 2-(4-ethylphenyl)phenol (CAS No. 374936-04-6)

2-(4-ethylphenyl)phenol, identified by the Chemical Abstracts Service Number (CAS No.) 374936-04-6, is a significant organic compound that has garnered attention in the field of pharmaceutical chemistry and materials science. This compound, featuring a phenolic structure with an ethyl-substituted aromatic ring, exhibits unique chemical properties that make it a valuable intermediate in the synthesis of various functional materials and bioactive molecules.

The molecular framework of 2-(4-ethylphenyl)phenol consists of two benzene rings connected through a hydroxyl-substituted carbon atom at the para position relative to the ethyl group on the second ring. This arrangement imparts distinct electronic and steric characteristics, enabling its utility in diverse chemical reactions and applications. The presence of both hydroxyl and ethyl groups allows for further functionalization, making it a versatile building block in organic synthesis.

In recent years, 2-(4-ethylphenyl)phenol has been explored for its potential in pharmaceutical research. Its aromatic system and hydroxyl functionality make it a candidate for developing novel therapeutic agents. Studies have indicated that derivatives of this compound may exhibit inhibitory effects on certain enzymatic pathways, which could be relevant in treating inflammatory diseases or metabolic disorders. The ethyl group at the para position enhances solubility and bioavailability, factors crucial for drug development.

Moreover, 2-(4-ethylphenyl)phenol has found applications in materials science, particularly in the synthesis of advanced polymers and coatings. Its phenolic structure contributes to the formation of stable aromatic networks, improving thermal stability and mechanical strength in polymer matrices. Researchers have investigated its incorporation into epoxy resins and polyurethane formulations to enhance material performance under extreme conditions.

The synthesis of 2-(4-ethylphenyl)phenol typically involves Friedel-Crafts alkylation followed by hydroxylation reactions. These steps require precise control over reaction conditions to achieve high yields and purity. Advances in catalytic systems have enabled more efficient production methods, reducing waste and energy consumption. Such improvements align with the growing emphasis on sustainable chemistry practices.

Recent research has also highlighted the role of 2-(4-ethylphenyl)phenol in nanotechnology applications. Its ability to form stable self-assembled structures makes it useful for creating functional nanostructures with tailored properties. These nanostructures have potential uses in drug delivery systems, where precise control over size and surface chemistry is essential for targeted therapeutic action.

The pharmacological potential of 2-(4-ethylphenyl)phenol has been further explored through computational modeling and high-throughput screening techniques. Virtual screening has identified promising analogs with enhanced biological activity, guiding experimental efforts toward more effective drug candidates. Such computational approaches are increasingly integral to modern drug discovery pipelines.

In conclusion, 2-(4-ethylphenyl)phenol (CAS No. 374936-04-6) is a multifaceted compound with significant applications across pharmaceuticals and materials science. Its unique structural features enable diverse functionalization strategies, making it a valuable intermediate in synthetic chemistry. As research continues to uncover new applications, this compound is poised to play an even greater role in advancing technological and medical innovations.

• 55258-78-1([1,1'-Biphenyl]-2-ol,4-(1-methylethyl)-)
• 160041-35-0([1,1'-Biphenyl]-2,2'-diol, 5,5'-bis[2-(3-hydroxyphenyl)ethyl]-)
• 20601-85-8(Tetrahydromagnolol)
• 85959-13-3([1,1'-Biphenyl]-2-ol,4-(phenylmethyl)-)
• 577-92-4(5-(tert-Butyl)-[1,1'-biphenyl]-2-ol)
• 78576-58-6([1,1'-Biphenyl]-2-ol, 3,3''-methylenebis-)
• 829666-62-8([1,1':3',1''-Terphenyl]-2,2''-diol, 5'-(2-hydroxy-5-pentylphenyl)-5,5''-dipentyl- (9CI))
• 918151-47-0([1,1'-Biphenyl]-2-ol, 3-(1-methylethyl)-)
• 13395-83-0([1,1'-Biphenyl]-4,4'-diol,3,3'-diethyl-5,5'-dimethyl-)
• 62224-31-1([1,1'-Biphenyl]-2,2'-diol, 5,5'-diethyl-)