• 1. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 2. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 5. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734

Introduction to (6-Bromo-benzobthiophen-2-yl)-methanol (CAS No. 374933-76-3)

(6-Bromo-benzobthiophen-2-yl-methanol) is a specialized organic compound with the CAS number 374933-76-3. This compound has garnered significant attention in the field of pharmaceutical chemistry and materials science due to its unique structural properties and potential applications. The benzobthiophene core, combined with a bromine substituent and a hydroxymethyl group, makes it a versatile intermediate for synthesizing various bioactive molecules and functional materials.

The structural motif of benzobthiophene is known for its stability and electronic characteristics, which make it a valuable scaffold in medicinal chemistry. The presence of a bromine atom at the 6-position enhances the reactivity of the molecule, allowing for further functionalization through cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings. These reactions are pivotal in constructing complex molecular architectures, including those found in modern drug candidates.

The hydroxymethyl group at the 2-position of the benzobthiophene ring introduces polarity and potential hydrogen bonding capabilities, which can be exploited in designing molecules with specific biological activities. This compound has been explored in the synthesis of kinase inhibitors, ligands for metalloproteinases, and other therapeutic agents targeting various diseases. The combination of these functional groups makes (6-Bromo-benzobthiophen-2-yl)-methanol a promising building block for drug discovery efforts.

Recent advancements in computational chemistry have enabled more efficient screening of compounds like (6-Bromo-benzobthiophen-2-yl)-methanol for their pharmacological potential. Molecular docking studies have shown that this molecule can interact with multiple targets, suggesting broad therapeutic applications. For instance, preliminary studies indicate that it may have inhibitory effects on certain enzymes involved in cancer progression and inflammation.

In materials science, the electronic properties of benzobthiophene derivatives are being leveraged to develop organic semiconductors and optoelectronic materials. The bromine substituent facilitates further modifications, allowing for the creation of polymers and small molecules with tailored optoelectronic properties. These materials are crucial for applications in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and other advanced technologies.

The synthesis of (6-Bromo-benzobthiophen-2-yl)-methanol typically involves multi-step organic transformations starting from commercially available precursors. Key steps include bromination of a benzobthiophene derivative followed by selective reduction to introduce the hydroxymethyl group. Advances in catalytic methods have improved the efficiency and selectivity of these reactions, making the synthesis more scalable and cost-effective.

The compound's stability under various conditions makes it suitable for long-term storage and transport, ensuring its availability for research and industrial applications. Its compatibility with standard solvents used in organic synthesis also simplifies its integration into larger synthetic schemes.

As research continues to uncover new applications for (6-Bromo-benzobthiophen-2-yl)-methanol, its importance in both academic and industrial settings is likely to grow. Collaborative efforts between chemists, biologists, and material scientists will be essential in fully realizing its potential across multiple domains.

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