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2-Amino-6-Morpholin-4-Yl-3H-Pyrimidin-4-One: A Comprehensive Overview

The compound with CAS No 37409-97-5, known as 2-Amino-6-Morpholin-4-Yl-3H-Pyrimidin-4-One, is a significant molecule in the field of organic chemistry and pharmacology. This compound belongs to the class of pyrimidinones, which are widely studied for their diverse biological activities. The pyrimidinone framework is a key structural element in many bioactive compounds, making it a focal point for research in drug discovery and development.

2-Amino-6-Morpholin-4-Yl-3H-Pyrimidin-4-One is characterized by its unique chemical structure, which includes a pyrimidinone ring substituted with an amino group at position 2 and a morpholinyl group at position 6. The presence of these substituents contributes to the compound's stability, solubility, and bioavailability. Recent studies have highlighted the importance of such substitutions in enhancing the pharmacokinetic properties of drugs, making this compound a promising candidate for therapeutic applications.

The synthesis of 2-Amino-6-Morpholin-4-Yl-3H-Pyrimidin-4-One involves a series of well-established organic reactions, including nucleophilic substitutions, condensations, and cyclizations. Researchers have optimized these reaction conditions to achieve high yields and purity levels. For instance, the use of microwave-assisted synthesis has been reported to significantly reduce reaction times while maintaining product quality. This approach aligns with the growing trend toward green chemistry practices in pharmaceutical research.

One of the most intriguing aspects of 2-Amino-6-Morpholin-4-Yl-3H-Pyrimidin-4-One is its biological activity. Recent studies have demonstrated its potential as an anti-inflammatory agent, with significant effects on reducing cytokine production in vitro. Additionally, this compound has shown promise in modulating cellular signaling pathways involved in neurodegenerative diseases, such as Alzheimer's disease. These findings underscore its potential as a lead compound for developing novel therapeutics.

In terms of applications, 2-Amino-6-Morpholin-4-Yl-3H-Pyrimidin-4-One has been extensively studied for its role in medicinal chemistry. Its ability to inhibit key enzymes involved in metabolic disorders has attracted attention from researchers in the field of diabetes and obesity. Furthermore, its anti-proliferative effects on cancer cells suggest its potential as an anti-cancer agent. These multifaceted applications highlight the versatility of this compound in addressing various therapeutic needs.

Recent advancements in computational chemistry have also played a pivotal role in understanding the molecular mechanisms underlying the activity of 2-Amino-6-Morpholin-4-Yl-3H-Pyrimidin-4-One. Molecular docking studies have revealed its binding affinity to critical protein targets, providing insights into its mode of action. Such computational approaches are increasingly being integrated with experimental techniques to accelerate drug discovery processes.

In conclusion, 2-Amino-6-Morpholin

• 19810-79-8(2-Morpholinopyrimidin-4(3H)-one)
• 1070215-62-1(2-amino-6-(4-methyl-1-piperazinyl)-4(3H)-Pyrimidinone)
• 1158775-43-9(2-Amino-6-piperazin-1-ylpyrimidin-4(3H)-one)
• 1077-04-9(2-Amino-6-(2-hydroxyethyl)amino-4(3H)-pyrimidinone)
• 61667-07-0(4(1H)-Pyrimidinone, 6-[(2-hydroxyethyl)amino]-)
• 104637-63-0(6-Amino-2-morpholin-4-ylpyrimidin-4(3H)-one)
• 1159814-36-4(4-Morpholin-4-yl-1H-pyrimidin-6-one)
• 674310-60-2(4(1H)-Pyrimidinone, 2-amino-6-(2-propenylamino)-)
• 37409-81-7(4(1H)-Pyrimidinone, 2,5-diamino-6-(4-morpholinyl)-)
• 164525-11-5(4(3H)-Pyrimidinone,2-amino-6-(ethylamino)-)