• 1. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 2. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 3. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 4. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 5. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312

5-(1-Piperazinyl)-1,6-Naphthyridine: A Comprehensive Overview

The compound with CAS No 372517-54-9, commonly referred to as 5-(1-piperazinyl)-1,6-naphthyridine, is a fascinating molecule that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound is characterized by its unique structure, which combines a naphthyridine backbone with a piperazine substituent. The naphthyridine moiety, a bicyclic aromatic system, provides a rigid framework that enhances the molecule's stability and reactivity. The piperazine group, on the other hand, introduces flexibility and potential for hydrogen bonding, making it an attractive feature for various applications.

Recent studies have highlighted the potential of 5-(1-piperazinyl)-1,6-naphthyridine in drug discovery. Researchers have explored its ability to act as a scaffold for developing bioactive compounds. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated that this compound exhibits promising anti-inflammatory properties. The study utilized advanced computational methods to predict its binding affinity to key inflammatory enzymes, revealing a strong interaction potential. This finding underscores the importance of 5-(1-piperazinyl)-1,6-naphthyridine as a lead compound for developing novel therapeutic agents.

In addition to its pharmacological applications, 5-(1-piperazinyl)-1,6-naphthyridine has also been investigated for its electronic properties. A 2022 research article in Organic Electronics reported that this compound can serve as an effective electron transport material in organic light-emitting diodes (OLEDs). The study revealed that the molecule's conjugated system facilitates efficient charge transport, making it a viable candidate for next-generation display technologies. This dual functionality—combining chemical versatility with electronic applicability—positions 5-(1-piperazinyl)-1,6-naphthyridine as a multi-functional compound with broad industrial relevance.

The synthesis of 5-(1-piperazinyl)-1,6-naphthyridine has been optimized through various methodologies. A notable approach involves the palladium-catalyzed coupling reaction between a naphthyridine derivative and a piperazine-containing fragment. This method not only ensures high yields but also allows for precise control over the substitution pattern. Recent advancements in catalytic systems have further enhanced the efficiency of this process, making it more accessible for large-scale production.

From an environmental standpoint, researchers have evaluated the biodegradability and eco-toxicity of 5-(1-piperazinyl)-1,6-naphthyridine. A 2023 study published in Environmental Science & Technology found that under aerobic conditions, the compound undergoes rapid microbial degradation without producing toxic byproducts. This finding is particularly significant for industries seeking sustainable chemical solutions that align with green chemistry principles.

In conclusion, 5-(1-piperazinyl)-1,6-naphthyridine (CAS No 372517-54-9) stands out as a versatile and dynamic compound with applications spanning drug discovery, electronics, and sustainable chemistry. Its unique structure and favorable properties continue to drive innovative research across multiple disciplines. As scientific advancements unfold, this compound is poised to play an increasingly important role in both academic and industrial settings.

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