Cas no 3704-01-6 (4-Desacetyl Vincristine Methosulfate)
4-Desacetyl Vincristine Methosulfate is a semi-synthetic vinca alkaloid derivative, structurally related to vincristine, with modifications enhancing its solubility and stability. This compound is primarily utilized in research applications, particularly in oncology studies, due to its potential as a microtubule-disrupting agent. Its methosulfate moiety improves water solubility, facilitating formulation and handling in experimental settings. The desacetyl modification may influence its pharmacokinetic profile, offering a distinct metabolic pathway compared to its parent compound. Researchers value this derivative for its ability to serve as an intermediate in the synthesis of other vinca alkaloids or as a reference standard in analytical studies. Its precise mechanism and applications remain under investigation in preclinical models.
3704-01-6 structure
Product Name:4-Desacetyl Vincristine Methosulfate
CAS No:3704-01-6
MF:C44H54N4O9
MW:782.92097234726
CID:854037
PubChem ID:131878567
Update Time:2025-05-28
4-Desacetyl Vincristine Methosulfate Chemical and Physical Properties
Names and Identifiers
-
- Vincaleukoblastine, O4-deacetyl-22-oxo-
- 4-Desacetyl Vincristine Methosulfate
- 4-DESACETYL VINCRISTINE METHOSULFATE,WHITE TO OFF-WHITE SOLID
- 4-deacetylvincristine
- 4-Vinylpyridoxal-5-phosphate
- 4-Vpdp
- 3704-01-6
- methyl 12-ethyl-4-(17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl)-8-formyl-10,11-dihydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
- 4-Desacetyl Vincristine
-
- Inchi： 1S/C44H54N4O9/c1-6-40(53)21-26-22-43(38(51)56-4,34-28(13-17-46(23-26)24-40)27-11-8-9-12-31(27)45-34)30-19-29-32(20-33(30)55-3)48(25-49)36-42(29)15-18-47-16-10-14-41(7-2,35(42)47)37(50)44(36,54)39(52)57-5/h8-12,14,19-20,25-26,35-37,45,50,53-54H,6-7,13,15-18,21-24H2,1-5H3/t26-,35-,36+,37+,40-,41+,42+,43-,44-/m0/s1
- InChI Key： YIQATJBOCJPFCF-XQLDGQACSA-N
- SMILES： O[C@]1(C(=O)OC)[C@@H]([C@@]2(C=CCN3CC[C@@]4(C5C=C([C@]6(C(=O)OC)C7=C(C8C=CC=CC=8N7)CCN7C[C@](CC)(C[C@H](C7)C6)O)C(=CC=5N(C=O)[C@H]41)OC)[C@@H]32)CC)O
Computed Properties
- Exact Mass: 782.38900
- Monoisotopic Mass: 782.38907931g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 4
- Hydrogen Bond Acceptor Count: 11
- Heavy Atom Count: 57
- Rotatable Bond Count: 8
- Complexity: 1630
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 9
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.8
- Topological Polar Surface Area: 165?2
Experimental Properties
- Melting Point: >300?C (dec.)
- PSA: 165.10000
- LogP: 3.52340
4-Desacetyl Vincristine Methosulfate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | D288729-1mg |
4-Desacetyl Vincristine Methosulfate |
3704-01-6 | 1mg |
$ 161.00 | 2023-09-08 | ||
| TRC | D288729-2mg |
4-Desacetyl Vincristine Methosulfate |
3704-01-6 | 2mg |
$ 287.00 | 2023-04-17 | ||
| TRC | D288729-5mg |
4-Desacetyl Vincristine Methosulfate |
3704-01-6 | 5mg |
$ 701.00 | 2023-09-08 | ||
| TRC | D288729-10mg |
4-Desacetyl Vincristine Methosulfate |
3704-01-6 | 10mg |
$ 1206.00 | 2023-09-08 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-206872-1 mg |
4-Desacetyl Vincristine Methosulfate, |
3704-01-6 | 1mg |
￥2,482.00 | 2023-07-11 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-206872-1mg |
4-Desacetyl Vincristine Methosulfate, |
3704-01-6 | 1mg |
￥2482.00 | 2023-09-05 | ||
| A2B Chem LLC | AF72049-1mg |
4-Desacetyl Vincristine |
3704-01-6 | 1mg |
$277.00 | 2024-04-20 | ||
| A2B Chem LLC | AF72049-5mg |
4-Desacetyl Vincristine |
3704-01-6 | 5mg |
$802.00 | 2024-04-20 | ||
| A2B Chem LLC | AF72049-10mg |
4-Desacetyl Vincristine |
3704-01-6 | 10mg |
$1292.00 | 2024-04-20 |
4-Desacetyl Vincristine Methosulfate Related Literature
-
Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
-
Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
-
Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
-
Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
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