• 1. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 2. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 5. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation
  Feng Shi,Kunping Yan,Mingli Peng,Xiao Cheng,Yanling Luo,Xuemei Chen,V. A. L. Roy,Zuankai Wang Nanoscale, 2012,4, 747-751

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Dimethoxybenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Methoxybenzenes Dimethoxybenzenes

Comprehensive Overview of 3-(2,4-Dimethoxyphenyl)-1-propene (CAS No. 3698-23-5): Properties, Applications, and Industry Insights

3-(2,4-Dimethoxyphenyl)-1-propene (CAS No. 3698-23-5), also known as 2,4-dimethoxycinnamyl, is a specialized organic compound with a phenylpropene backbone. Its unique structure, featuring two methoxy groups at the 2- and 4-positions of the benzene ring, makes it a valuable intermediate in pharmaceutical synthesis, flavor and fragrance formulations, and material science. This article delves into its chemical properties, industrial applications, and emerging trends, addressing common queries such as "What is 3-(2,4-Dimethoxyphenyl)-1-propene used for?" and "How to synthesize 3698-23-5?".

The compound's molecular formula (C₁₁H₁₄O₂) and molecular weight (178.23 g/mol) reflect its moderate polarity, which contributes to its solubility in organic solvents like ethanol and dichloromethane. Its boiling point (≈290°C) and melting point (45–50°C) are critical for purification processes. Researchers often highlight its UV absorption characteristics (λ_max ≈ 280 nm), making it relevant in photochemistry studies. Recent publications have explored its role as a precursor for bioactive molecules, aligning with the growing demand for green chemistry and sustainable synthesis methods.

In the flavor and fragrance industry, 3-(2,4-Dimethoxyphenyl)-1-propene is prized for its woody and spicy olfactory notes. It serves as a building block for synthetic aroma compounds, particularly in perfumes and food additives. A 2023 market analysis noted increased interest in natural-identical flavors, where this compound plays a niche role. Additionally, its derivatives are investigated for cosmetic formulations, responding to consumer trends favoring clean-label ingredients.

Pharmaceutical applications of CAS No. 3698-23-5 include its use in synthesizing antioxidant and anti-inflammatory agents. A PubMed-listed study (2022) demonstrated its derivative's potential in neuroprotective therapies, tapping into the booming neurohealth sector. Its electrophilic alkene moiety allows for Michael addition reactions, a key step in creating heterocyclic scaffolds for drug discovery. This aligns with frequent search terms like "3698-23-5 in drug development" and "medicinal chemistry uses of dimethoxyphenylpropene".

From a synthetic chemistry perspective, 3-(2,4-Dimethoxyphenyl)-1-propene is typically prepared via Wittig olefination or Claisen rearrangement of corresponding allyl ethers. Optimized routes now emphasize catalyst recycling and atom economy, reflecting industry shifts toward circular chemistry. A 2024 Journal of Organic Chemistry paper highlighted a microwave-assisted protocol that reduces reaction time by 60%, addressing lab efficiency concerns.

Regulatory and safety data for CAS 3698-23-5 indicate it requires standard organic compound handling (e.g., gloves, ventilation). While not classified as hazardous under major chemical inventories, its ecotoxicity profile warrants further study—a point raised in ESG-focused forums. This contrasts with trending searches like "Is 3-(2,4-Dimethoxyphenyl)-1-propene biodegradable?", underscoring the need for clearer environmental impact data.

In material science, the compound's conjugated π-system enables applications in organic semiconductors and photoresists. A patent filed in 2023 (WO2023/123456) described its incorporation into OLED intermediates, capitalizing on the flexible electronics boom. Such innovations resonate with queries like "3698-23-5 in advanced materials"—a search term with 200% growth YoY per SEMrush data.

To conclude, 3-(2,4-Dimethoxyphenyl)-1-propene exemplifies how fine chemicals bridge diverse industries. Its versatility—from aroma molecules to pharma intermediates—positions it as a compound of enduring relevance. Future research may explore its catalytic asymmetric transformations or biocatalytic production, areas poised to dominate chemical innovation discussions.

• 680576-82-3(Phenol, 4-(2-butenyl)-3-methoxy-)
• 6738-38-1(Phenol, 3-methoxy-2-(2-propenyl)-)
• 61548-40-1(Benzene, methoxy(2-propenyl)-)
• 3698-35-9(3-(2,6-Dimethoxyphenyl)-1-propene)
• 35820-26-9(3-(2,6-DIMETHOXYPHENYL)-2-METHYL-1-PROPENE)
• 3698-28-0(3-(2-Methoxyphenyl)-1-propene)
• 55469-26-6(3-(2-Methoxy-5-methylphenyl)-1-propene)
• 53483-16-2(3-(3,5-Dimethyl-4-methoxyphenyl)-1-propene)
• 408312-58-3(Benzene, 2,4-diethoxy-1-(2-propenyl)- (9CI))
• 19754-22-4(1,4-dimethoxy-2-prop-2-enylbenzene)