Cas no 369-54-0 (1,4-Bis(difluoromethyl)benzene)
1,4-Bis(difluoromethyl)benzene is a fluorinated aromatic compound characterized by the presence of two difluoromethyl groups symmetrically substituted at the 1 and 4 positions of the benzene ring. This structure imparts unique chemical properties, including enhanced stability and reactivity in fluorination reactions. The compound is particularly valuable as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials, where the introduction of fluorine atoms is critical for modulating biological activity or material performance. Its high purity and well-defined structure make it a reliable building block for precision organic synthesis. Additionally, the difluoromethyl groups contribute to improved lipophilicity, which can be advantageous in drug design.
369-54-0 structure
Product Name:1,4-Bis(difluoromethyl)benzene
CAS No:369-54-0
MF:C8H6F4
MW:178.126856327057
MDL:MFCD01320708
CID:82212
PubChem ID:87577507
Update Time:2025-10-29
1,4-Bis(difluoromethyl)benzene Chemical and Physical Properties
Names and Identifiers
-
- 1,4-Bis(difluoromethyl)benzene
- 1,4-Bis-(difluoromethyl)benzene
- alpha,alpha,alpha',alpha'-Tetrafluoro-p-xylene
- &alpha
- ',&alpha
- p-Xylylene α,α,α',α'-Tetrafluoride
- α,α,α',α'-Tetrafluoro-p-xylene
- 2-CF2H
- Benzene,1,4-bis(difluoromethyl)-
- SBB089374
- PC0502
- 1,4-bis[bis(fluoranyl)methyl]benzene
- FCH1116340
- AX8054460
- ST50406044
- ST24036837
- X8269
- alpha,alpha,alpha,alpha-Tetrafluoro-p-xylene
- p-Xylylene alpha,alpha,al
- 1,4-Bis(difluoromethyl)benzene, stabilized over potassium carbonate
- VWKMZVCSRVFUGW-UHFFFAOYSA-N
- A823480
- 369-54-0
- AKOS016007464
- CIS-8,11,14-EICOSATRIENOICACIDMETHYLESTER
- a,a,a',a'-Tetrafluoro-p-xylene
- FT-0606797
- T1774
- SCHEMBL662302
- MFCD01320708
- AS-60198
- DTXSID40370092
- CS-0077608
- p-Xylylene alpha,alpha,alpha',alpha'-Tetrafluoride
- DB-121194
-
- MDL： MFCD01320708
- Inchi： 1S/C8H6F4/c9-7(10)5-1-2-6(4-3-5)8(11)12/h1-4,7-8H
- InChI Key： VWKMZVCSRVFUGW-UHFFFAOYSA-N
- SMILES： FC(C1C=CC(C(F)F)=CC=1)F
Computed Properties
- Exact Mass: 178.04100
- Monoisotopic Mass: 178.041
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 12
- Rotatable Bond Count: 2
- Complexity: 111
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 3.2
- Topological Polar Surface Area: 0
Experimental Properties
- Color/Form: Not available
- Density: 1.225±0.06 g/cm3 (20 oC 760 Torr),
- Boiling Point: 70°C/20mmHg(lit.)
- Flash Point: 66.8±14.6 oC,
- Refractive Index: 1.4378 (589.3 nm 25 oC)
- Solubility: Insuluble (9.4E-3 g/L) (25 oC),
- PSA: 0.00000
- LogP: 3.56180
- Solubility: Not available
1,4-Bis(difluoromethyl)benzene Security Information
- Prompt：warning
- Hazard Statement： H227
- Warning Statement： P210-P280-P403+P235-P501
- Hazard Category Code： 36/37/38-10
- Safety Instruction： S37/39-S26-S16
-
Hazardous Material Identification：
- Safety Term：S16;S26;S37/39
- Packing Group：III
- Packing Group：III
- Risk Phrases：R10; R36/37/38
- PackingGroup：III
- Storage Condition：Flammable area
1,4-Bis(difluoromethyl)benzene Customs Data
- HS CODE：2903999090
- Customs Data：
China Customs Code:
2903999090Overview:
2903999090 Other aromatic halogenated derivatives. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
1,4-Bis(difluoromethyl)benzene Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A151373-1g |
1,4-Bis(difluoromethyl)benzene |
369-54-0 | >98.0%(GC) | 1g |
￥95.90 | 2023-09-04 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A151373-25G |
1,4-Bis(difluoromethyl)benzene |
369-54-0 | >98.0%(GC) | 25g |
￥1160.90 | 2023-09-04 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A151373-5G |
1,4-Bis(difluoromethyl)benzene |
369-54-0 | >98.0%(GC) | 5g |
￥290.90 | 2023-09-04 | |
| Chemenu | CM304462-100g |
1,4-Bis(difluoromethyl)benzene |
369-54-0 | 95+% | 100g |
$515 | 2021-06-16 | |
| TRC | D445223-50mg |
1,4-bis(Difluoromethyl)benzene |
369-54-0 | 50mg |
$ 50.00 | 2022-06-05 | ||
| TRC | D445223-100mg |
1,4-bis(Difluoromethyl)benzene |
369-54-0 | 100mg |
$ 65.00 | 2022-06-05 | ||
| TRC | D445223-500mg |
1,4-bis(Difluoromethyl)benzene |
369-54-0 | 500mg |
$ 80.00 | 2022-06-05 | ||
| BAI LING WEI Technology Co., Ltd. | 273682-1G |
1,4-Bis(difluoromethyl)benzene, 98% |
369-54-0 | 98% | 1G |
￥ 113 | 2022-04-26 | |
| BAI LING WEI Technology Co., Ltd. | 273682-5G |
1,4-Bis(difluoromethyl)benzene, 98% |
369-54-0 | 98% | 5G |
￥ 406 | 2022-04-26 | |
| Apollo Scientific | PC0502-5g |
1,4-Bis(difluoromethyl)benzene |
369-54-0 | 98% | 5g |
￡71.00 | 2024-08-03 |
1,4-Bis(difluoromethyl)benzene Suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier
(CAS:369-54-0)1,4-雙(二氟甲基)苯
Order Number:LE1647625
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:31
Price ($):discuss personally
Email:[email protected]
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier
(CAS:369-54-0)1,4-Bis-(difluoromethyl)benzene
Order Number:1647625
Stock Status:in Stock
Quantity:Company Customization
Purity:98%
Pricing Information Last Updated:Monday, 14 April 2025 21:49
Price ($):discuss personally
Email:[email protected]
Amadis Chemical Company Limited
Gold Member
Audited Supplier
(CAS:369-54-0)1,4-Bis(difluoromethyl)benzene
Order Number:A823480
Stock Status:in Stock
Quantity:25g/100g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 16:10
Price ($):284.0/936.0
Email:[email protected]
1,4-Bis(difluoromethyl)benzene Related Literature
-
Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
-
Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
-
Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
-
Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
-
Zhonghua Xiang,Chuanqi Fang,Sanhua Leng,Dapeng Cao J. Mater. Chem. A, 2014,2, 7662-7665
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