Cas no 3685-22-1 (cis-4-hydroxycyclohexanecarboxylic acid)

Technical Introduction: cis-4-Hydroxycyclohexanecarboxylic Acid cis-4-Hydroxycyclohexanecarboxylic acid is a cyclic hydroxycarboxylic acid featuring a hydroxyl group and a carboxyl group in the cis configuration on a cyclohexane ring. This stereospecific structure imparts unique reactivity, making it valuable as an intermediate in organic synthesis, pharmaceuticals, and specialty chemicals. Its rigid cyclohexane backbone enhances stability, while the functional groups allow for further derivatization, such as esterification or amidation. The cis-configuration influences its solubility and hydrogen-bonding properties, distinguishing it from the trans isomer. This compound is particularly useful in chiral synthesis and polymer applications, where precise stereochemistry is critical. High purity grades ensure consistent performance in research and industrial processes.

cis-4-hydroxycyclohexanecarboxylic acid structure

3685-22-1 structure

Product Name:cis-4-hydroxycyclohexanecarboxylic acid

CAS No:3685-22-1

MF:C₇H₁₂O₃

MW:144.168382644653

MDL:MFCD04038017

CID:296319

PubChem ID:87571336

Update Time:2025-06-11

cis-4-hydroxycyclohexanecarboxylic acid Chemical and Physical Properties

Names and Identifiers

- cis-4-Hydroxycyclohexanecarboxylic Acid
- Cyclohexanecarboxylicacid, 4-hydroxy-, cis-
- TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
- 4-hydroxycyclohexylcarboxylic acid
- 4-hydroxycylohexane carboxylic acid
- cis
- cis-4-Hydroxycyclohexane-1-carboxylic acid
- Cyclohexanecarboxylic acid,4-hydroxy-,cis
- trans-ethyl 4-hydroxycyclohexanecarboxylic acid
- 4-Hydroxycyclohexanecarboxylic acid
- 4-hydroxycyclohexane-1-carboxylic acid
- Trans 4-hydroxycyclohexane carboxylic acid
- 4-Hydroxycyclohexane carboxylic acid
- (1s,4s)-4-Hydroxycyclohexanecarboxylic acid
- Cyclohexanecarboxylic acid, 4-hydroxy-, cis-
- Cyclohexanecarboxylic acid, 4-hydroxy-, trans-
- Cyclohexanecarboxylic acid, 4-hydroxy-
- (1r,4r)-4-hydroxycyclo
- (1r,4r)-4-hydroxycyclohexanecarboxylic acid
- EN300-51638
- BP-12592
- Trans-4-hydroxycyclohexane carboxylic acid
- C04404
- SCHEMBL601356
- DTXSID30190327
- MFCD04038017
- HCFRWBBJISAZNK-UHFFFAOYSA-
- CS-0049675
- Q27102091
- CHEBI:16817
- Cyclohexanecarboxylicacid,4-hydroxy-,trans-
- H0980
- cis-4-HydroxycyclohexanecarboxylicAcid
- 4-Amino-1-ethyl-4-piperidinecarboxylicacid
- 3685-22-1
- SCHEMBL8122649
- DTXSID901015736
- HY-76199
- SY011572
- PD099462
- HCFRWBBJISAZNK-UHFFFAOYSA-N
- Q27161527
- trans-4-Hydroxycyclohexylcarboxylic acid
- SCHEMBL10444969
- (1s,4s)-4-hydroxycyclohexane-1-carboxylic acid
- MFCD02093477
- SY016503
- InChI=1/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)
- 4-hydroxy-cyclohexanecarboxylic acid
- SCHEMBL160291
- trans-4-hydroxy-cyclohexanecarboxylic acid
- 17419-81-7
- SY285104
- FT-0618710
- SB11014
- SY011571
- CHEBI:89341
- 3685-26-5
- AKOS006379357
- NS00121843
- 4-Hchc
- AKOS006240038
- H1175
- P10217
- BP-10793
- DS-4536
- cis-4-Hydroxycyclohexanecarboxylic acid, AldrichCPR
- AM9679
- A823404
- SB15659
- AMY34072
- BP-21175
- AKOS004120820
- A811620
- (cis)-4-hydroxycyclohexanecarboxylic acid
- TS-01880
- Cis-4-hydroxy-cyclohexanecarboxylic acid
- FT-0656895
- BCP30118
- 4-hydroxycyclohexane
- Z336079608
- AC-495
- 4-hydroxycylohexanecarboxylic acid
- CS-W016391
- PD124080
- cis-4-Hydroxycyclohexane carboxylic acid
- BCP28156
- SCHEMBL482042
- MFCD00077974
- A874260
- H0960
- AM9676
- P10288
- 1-(2,4-DINITROPHENYL)-PIPERAZINEHCL
- s6069
- Trans-4-hydroxycyclohexanecarboxylic acid;4-Hydroxycyclohexane-1-carboxylic acid
- AS-50460
- FT-0700977
- SB11015
- HY-W015675
- (trans)-4-hydroxycyclohexanecarboxylic acid
- CS-M0763
- 4-Hydroxycyclohexanecarboxylic acid, AldrichCPR
- C22885
- cis-4-hydroxycyclohexane-1-carboxylate
- DB-002962
- cis-4-hydroxycyclohexanecarboxylate
- 1ST2676
- trans-4-Hydroxycyclohexane-1-carboxylate
- DA-68300
- (1R,4R)-4-HYDROXYCYCLOHEXANE-1-CARBOXYLIC ACID
- 4-Hydroxyhexahydrobenzoic acid
- 4-Hydroxycylohexanecarboxylic Acid; (1r,2r)-4-Hydroxycyclohexan-1-carboxylic Acid
- cis-4-hydroxycyclohexanecarboxylic acid
- MDL： MFCD04038017
- Inchi： 1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)
- InChI Key： HCFRWBBJISAZNK-UHFFFAOYSA-N
- SMILES： OC1CCC(C(=O)O)CC1

Computed Properties

Exact Mass: 144.07900
Monoisotopic Mass: 144.078644241g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 10
Rotatable Bond Count: 1
Complexity: 125
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Topological Polar Surface Area: 57.5
Surface Charge: 0
Tautomer Count: nothing
XLogP3: 0.3

Experimental Properties

Density: 1.246
Melting Point: 148.0 to 152.0 deg-C
Boiling Point: 307.9℃ at 760 mmHg
PSA: 57.53000
LogP: 0.62210

cis-4-hydroxycyclohexanecarboxylic acid Security Information

Symbol:
Prompt：warning
Hazard Statement： H315-H319
Warning Statement： P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Category Code： 36/37/38-25
Safety Instruction： S26-S36-S37-S39
Hazardous Material Identification：
Risk Phrases：R36/37/38

cis-4-hydroxycyclohexanecarboxylic acid Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.	H862074-5g	cis-4-Hydroxycyclohexanecarboxylic Acid	3685-22-1	≥98%(GC)(T)	5g	896.00	2021-05-17
CHENG DOU FEI BO YI YAO Technology Co., Ltd.	FB05105-25g	cis-4-hydroxycyclohexanecarboxylic acid	3685-22-1	95%	25g	$380	2023-09-07
TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd.	H0980-25G	cis-4-Hydroxycyclohexanecarboxylic Acid	3685-22-1	>98.0%(GC)(T)	25g	￥1550.00	2024-04-16
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.	S94290-1g	cis-4-Hydroxycyclohexanecarboxylic acid	3685-22-1		1g	￥206.0	2021-09-07
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.	S94290-25g	cis-4-Hydroxycyclohexanecarboxylic acid	3685-22-1		25g	￥1836.0	2021-09-07
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.	S94290-5g	cis-4-Hydroxycyclohexanecarboxylic acid	3685-22-1		5g	￥626.0	2021-09-07
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.	S94290-250mg	cis-4-Hydroxycyclohexanecarboxylic acid	3685-22-1		250mg	￥116.0	2021-09-07
TRC	R729038-50mg	trans-4-Hydroxycyclohexanecarboxylic Acid	3685-22-1		50mg	$ 58.00	2023-09-06
TRC	R729038-100mg	trans-4-Hydroxycyclohexanecarboxylic Acid	3685-22-1		100mg	$ 75.00	2023-09-06
TRC	R729038-500mg	trans-4-Hydroxycyclohexanecarboxylic Acid	3685-22-1		500mg	$ 92.00	2023-09-06

cis-4-hydroxycyclohexanecarboxylic acid Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:3685-22-1)cis-4-hydroxycyclohexanecarboxylic acid

Order Number:A874260

Stock Status:in Stock

Quantity:100g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 09:42

Price ($):468.0

Email:[email protected]

Product Official Link

cis-4-hydroxycyclohexanecarboxylic acid Related Literature

1. Direct synthesis of C-glycosides from unprotected 2-N-acyl-aldohexoses via aldol condensation–oxa-Michael reactions with unactivated ketones

Sherida Johnson,Fujie Tanaka Org. Biomol. Chem. 2016 14 259

Related Categories

Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Cyclohexanols

Additional information on cis-4-hydroxycyclohexanecarboxylic acid

Cis-4-Hydroxycyclohexanecarboxylic Acid (CAS No. 3685-22-1): A Comprehensive Overview

Cis-4-hydroxycyclohexanecarboxylic acid, identified by the Chemical Abstracts Service Number (CAS No.) 3685-22-1, is a significant compound in the realm of organic chemistry and pharmaceutical research. This molecule, characterized by its cyclohexane ring with a hydroxyl group at the 4-position and a carboxylic acid moiety, has garnered attention due to its versatile applications and structural properties. The compound's unique stereochemistry, specifically the cis configuration, contributes to its distinct reactivity and potential biological interactions.

The cis-4-hydroxycyclohexanecarboxylic acid structure is a derivative of cyclohexane, which is a common scaffold in natural products and synthetic molecules. The presence of both a hydroxyl and a carboxylic acid group makes it an interesting candidate for various chemical transformations, including esterification, amidation, and oxidation processes. These functional groups also enable interactions with biological targets, making it a valuable building block in drug discovery.

In recent years, the pharmaceutical industry has shown increasing interest in molecules with cyclohexane derivatives due to their potential to modulate biological pathways. The cis-4-hydroxycyclohexanecarboxylic acid has been explored in several preclinical studies for its potential applications in treating inflammatory diseases and neurological disorders. Its ability to engage with specific enzymes and receptors has led researchers to investigate its role as an intermediate in the synthesis of novel therapeutic agents.

One of the most compelling aspects of cis-4-hydroxycyclohexanecarboxylic acid is its stereochemical flexibility. The cis configuration of the hydroxyl group influences the molecule's solubility, binding affinity, and metabolic stability. These factors are crucial in determining the compound's efficacy and safety profile when used in pharmaceutical formulations. Recent studies have highlighted the importance of stereochemistry in drug design, emphasizing that small changes in molecular structure can significantly impact biological activity.

The synthesis of cis-4-hydroxycyclohexanecarboxylic acid has been optimized through various methodologies, including asymmetric synthesis and catalytic hydrogenation. These techniques allow for high enantioselectivity and yield, making the compound more accessible for industrial applications. The advancements in synthetic chemistry have enabled researchers to produce large quantities of this compound for both research and commercial purposes.

Beyond its pharmaceutical applications, cis-4-hydroxycyclohexanecarboxylic acid has found utility in materials science and chemical manufacturing. Its structural properties make it a suitable candidate for developing novel polymers and coatings with enhanced durability and functionality. Additionally, the compound's ability to participate in hydrogen bonding networks has been exploited in designing supramolecular assemblies and molecular recognition systems.

The growing body of research on cis-4-hydroxycyclohexanecarboxylic acid underscores its significance as a versatile chemical entity. Ongoing studies are exploring its potential role in green chemistry initiatives, where it could serve as a sustainable alternative to more traditional synthetic intermediates. The compound's biodegradability and low toxicity profile make it an attractive option for environmentally friendly chemical processes.

In conclusion, cis-4-hydroxycyclohexanecarboxylic acid (CAS No. 3685-22-1) represents a fascinating molecule with broad applications across multiple scientific disciplines. Its unique structural features, coupled with its reactivity and biological potential, position it as a key player in modern chemical research. As advancements continue to unfold in synthetic methodologies and drug discovery technologies, the importance of compounds like this is expected to grow even further.

3685-22-1 (cis-4-hydroxycyclohexanecarboxylic acid) Related Products

Recommended suppliers